Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Janet Dell-John"'
Autor:
Marco M. Gottardis, Ricardo M. Attar, Robert Kramer, Dolatrai Vyas, George Trainor, Aixin Li, Krista Menard, Lorell Discenza, Cliff Chen, Janet Dell-John, Glenn H. Cantor, Carolyn Cao, Stephen Hillerman, Warren Hurlburt, Ann Greer, Francis Lee, Zheng Yang, Mark Wittman, Joan M. Carboni
Supplementary Tables 1-6 from BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb573ea3b1cac91d2db653d78a7f6e8
https://doi.org/10.1158/1535-7163.22485209.v1
https://doi.org/10.1158/1535-7163.22485209.v1
Autor:
Marco M. Gottardis, Ricardo M. Attar, Robert Kramer, Dolatrai Vyas, George Trainor, Aixin Li, Krista Menard, Lorell Discenza, Cliff Chen, Janet Dell-John, Glenn H. Cantor, Carolyn Cao, Stephen Hillerman, Warren Hurlburt, Ann Greer, Francis Lee, Zheng Yang, Mark Wittman, Joan M. Carboni
Supplementary Figure 1 from BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebdda8326e710242923e515affb3ab3
https://doi.org/10.1158/1535-7163.22485215
https://doi.org/10.1158/1535-7163.22485215
Autor:
Marco M. Gottardis, Ricardo M. Attar, Robert Kramer, Dolatrai Vyas, George Trainor, Aixin Li, Krista Menard, Lorell Discenza, Cliff Chen, Janet Dell-John, Glenn H. Cantor, Carolyn Cao, Stephen Hillerman, Warren Hurlburt, Ann Greer, Francis Lee, Zheng Yang, Mark Wittman, Joan M. Carboni
BMS-754807 is a potent and reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases (Ki, in vitro, including mesenchymal (Ewing's, rhabdomyosarcoma, neuroblastoma, and liposarcoma), epithelial (breast, lung, p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc63230107c1e05a299e1da8aaf1d21
https://doi.org/10.1158/1535-7163.c.6531836.v1
https://doi.org/10.1158/1535-7163.c.6531836.v1
Autor:
Marco M. Gottardis, Ricardo M. Attar, Robert Kramer, Dolatrai Vyas, George Trainor, Aixin Li, Krista Menard, Lorell Discenza, Cliff Chen, Janet Dell-John, Glenn H. Cantor, Carolyn Cao, Stephen Hillerman, Warren Hurlburt, Ann Greer, Francis Lee, Zheng Yang, Mark Wittman, Joan M. Carboni
Legends for Supplementary Figures 1-2, Tables 1-6 from BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2c544b8ee16f58175edab160b033f4
https://doi.org/10.1158/1535-7163.22485218
https://doi.org/10.1158/1535-7163.22485218
Autor:
Marco M. Gottardis, Ricardo M. Attar, Robert Kramer, Dolatrai Vyas, George Trainor, Aixin Li, Krista Menard, Lorell Discenza, Cliff Chen, Janet Dell-John, Glenn H. Cantor, Carolyn Cao, Stephen Hillerman, Warren Hurlburt, Ann Greer, Francis Lee, Zheng Yang, Mark Wittman, Joan M. Carboni
Supplementary Figure 2 from BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92fde8b5e3b4189da038ca18d952d52
https://doi.org/10.1158/1535-7163.22485212.v1
https://doi.org/10.1158/1535-7163.22485212.v1
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Table 1 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea96b450993c30817e08b09d67ecd09
https://doi.org/10.1158/0008-5472.22377966
https://doi.org/10.1158/0008-5472.22377966
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Table 2 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77108c0dff54d0d9d17df83470660395
https://doi.org/10.1158/0008-5472.22377963.v1
https://doi.org/10.1158/0008-5472.22377963.v1
Autor:
Marco M. Gottardis, Robert Kramer, Gregory Vite, Shen-Jue Chen, Joseph Dinchuk, William R. Foster, Mark E. Salvati, Weifang Shan, Mary Obermeier, J. Suso Platero, Thomas E. Spires, Liang Schweizer, Cheryl A. Rizzo, Janet Dell-John, Mary Ellen Cvijic, Aaron Balog, Maria Jure-Kunkel, Ricardo M. Attar
Supplementary Figure and Table Legends 1-2 from Discovery of BMS-641988, a Novel and Potent Inhibitor of Androgen Receptor Signaling for the Treatment of Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c30c0ceeb3ee6de838292a026446d0
https://doi.org/10.1158/0008-5472.22377969
https://doi.org/10.1158/0008-5472.22377969
Autor:
Janet Dell-John, John D. Dimarco, Cheryl A. Rizzo, Mark E. Salvati, Steven H. Spergel, Gregory Scott Martin, Weifang Shan, Aaron Balog, Georgia Cornelius, Richard Rampulla, Marco M. Gottardis, Andrew Nation, Christian L. Holst, Liang Schweizer, Gregory D. Vite, Lana M. Rossiter, Ricardo M. Attar, David J. Fairfax, Thomas E. Spires, Stanley R. Krystek, George L. Trainor, Jack Z. Gougoutas
Publikováno v:
ACS Medicinal Chemistry Letters. 6:908-912
BMS-641988 (23) is a novel, nonsteroidal androgen receptor antagonist designed for the treatment of prostate cancer. The compound has high binding affinity for the AR and acts as a functional antagonist in vitro. BMS-641988 is efficacious in multiple
Autor:
Hai-Yun Xiao, Jieping Geng, David J. Fairfax, Thomas E. Spires, Wen-Ching Han, Marco M. Gottardis, Mark E. Salvati, Andrew Nation, Weifang Shan, Mary-Ellen Cvjic, Jing Chen, Liang Schweizer, Mary T. Obermeier, Gregory Scott Martin, Ricardo M. Attar, Gregory D. Vite, Aaron Balog, Ashvinikumar V. Gavai, Janet Dell-John, Cheryl A. Rizzo, Lana M. Rossiter, Linda B. Fleming, Christian L. Holst
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4491-4495
A novel series of 4-[3,5-dioxo-11-oxa-4,9-diazatricyclo[5.3.1.0(2,6)]undec-4-yl]-2-trifluoromethyl-benzonitriles has been synthesized. The ability of these compounds to act as antagonists of the androgen receptor was investigated and several were fou