Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Janet Dawson"'
Autor:
Nathalie Accart, Janet Dawson, Michael Obrecht, Christian Lambert, Manuela Flueckiger, Julie Kreider, Shinji Hatakeyama, Peter J. Richards, Nicolau Beckmann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The objective of this work was to assess the consequences of repeated intra-articular injection of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) in order to simulate recurrent bouts of gout in rats. Tr
Externí odkaz:
https://doaj.org/article/6ccf86dc007b45ae93bccbf17995c98e
Autor:
Thomas Hoyler, Bettina Bannert, Cédric André, Damian Beck, Thomas Boulay, David Buffet, Nadja Caesar, Thomas Calzascia, Janet Dawson, Diego Kyburz, Robert Hennze, Christine Huppertz, Amanda Littlewood-Evans, Pius Loetscher, Kirsten D. Mertz, Satoru Niwa, Gautier Robert, James S. Rush, Giulia Ruzzante, Sophie Sarret, Thomas Stein, Ismahane Touil, Grazyna Wieczorek, Geraldine Zipfel, Stuart Hawtin, Tobias Junt
Publikováno v:
JCI Insight, Vol 7, Iss 13 (2022)
IL-1 receptor-activated kinase 1 (IRAK1) is involved in signal transduction downstream of many TLRs and the IL-1R. Its potential as a drug target for chronic inflammatory diseases is underappreciated. To study its functional role in joint inflammatio
Externí odkaz:
https://doaj.org/article/6fc6e2c6d008483f99d660e2370be0ce
Autor:
Ulf Guendisch, Jessica Weiss, Florence Ecoeur, Julia Christina Riker, Klemens Kaupmann, Joerg Kallen, Samuel Hintermann, David Orain, Janet Dawson, Andreas Billich, Christine Guntermann
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188391 (2017)
Retinoic acid receptor-related-orphan-receptor-C (RORγt) is the key transcription factor that is driving the differentiation of IL-17 producing T-helper 17 (Th17) cells that are implicated in the pathology of various autoimmune and inflammatory dise
Externí odkaz:
https://doaj.org/article/6839b528280445038584f573c6fe3d0d
Autor:
Marc Bigaud, Zuhal Dincer, Birgit Bollbuck, Janet Dawson, Nicolau Beckmann, Christian Beerli, Gina Fishli-Cavelti, Michaela Nahler, Daniela Angst, Philipp Janser, Heike Otto, Elisabeth Rosner, Rene Hersperger, Christian Bruns, Jean Quancard
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168252 (2016)
Homeostasis of vascular barriers depends upon sphingosine 1-phosphate (S1P) signaling via the S1P1 receptor. Accordingly, S1P1 competitive antagonism is known to reduce vascular barrier integrity with still unclear pathophysiological consequences. Th
Externí odkaz:
https://doaj.org/article/d21025381568439f81e9c5673c237ad7
Autor:
Andrew T Miller, Carol Dahlberg, Mark L Sandberg, Ben G Wen, Daniel R Beisner, John A H Hoerter, Albert Parker, Christian Schmedt, Monique Stinson, Jacqueline Avis, Cynthia Cienfuegos, Mark McPate, Pamela Tranter, Martin Gosling, Paul J Groot-Kormelink, Janet Dawson, Shifeng Pan, Shin-Shay Tian, H Martin Seidel, Michael P Cooke
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131071 (2015)
Emerging approaches to treat immune disorders target positive regulatory kinases downstream of antigen receptors with small molecule inhibitors. Here we provide evidence for an alternative approach in which inhibition of the negative regulatory inosi
Externí odkaz:
https://doaj.org/article/60911ac9821349a2a5779985bf95458d
Autor:
Janet Dawson
Publikováno v:
Philologia Hispalensis, Vol 13, Iss 2 (1999)
No hay resumen
Externí odkaz:
https://doaj.org/article/92f6e39e153c4d41815b096e4dd5ee90
Autor:
Christian Markert, Shin Numao, Petra Jäger, Gebhard Thoma, Rudolf Wälchli, Grazyna Wieczorek, Nathalie Wack, Franziska Hasler, Jürgen Hinrichs, Rainer M. Lüönd, Christian Beerli, Honnappa Srinivas, Amanda Littlewood-Evans, Pius Loetscher, Kai Klein, Carlos A. Penno, Kamal Azzaoui, Romain M. Wolf, Birgit Bollbuck, Till A. Röhn, Christian Bergsdorf, Wolfgang Miltz, Janet Dawson
Publikováno v:
Journal of Medicinal Chemistry. 64:1889-1903
The cytosolic metalloenzyme leukotriene A4 hydrolase (LTA4H) is the final and rate-limiting enzyme in the biosynthesis of pro-inflammatory leukotriene B4 (LTB4). Preclinical studies have validated this enzyme as an attractive drug target in chronic i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::208c74664f1cf048b5387b6f462e34b0
https://doi.org/10.1021/acs.jmedchem.0c01955
https://doi.org/10.1021/acs.jmedchem.0c01955
Autor:
Lorenz Meinel, Janet Dawson, Tessa Lühmann, Amanda Littlewood-Evans, Bruno Tigani, Martina Raschig, Valerie Spieler, Marie-Gabrielle Ludwig, Hilmar Ebersbach, Caterina Safina, Björn ter Mors, Thomas Müller, Klaus Seuwen
Publikováno v:
Journal of Controlled Release. 326:172-180
Anti-inflammatory cytokines are a promising class of therapeutics for treatment of rheumatoid arthritis (RA), but their use is currently limited by a rapid clearance and systemic toxicity. Interleukin-4 is a small cytokine with potential for RA thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ba66f3cba718f4e4dbe3cdc5422ff5
https://doi.org/10.1016/j.jconrel.2020.07.005
https://doi.org/10.1016/j.jconrel.2020.07.005
Autor:
Nathalie Accart, Janet Dawson, Nicolau Beckmann, Julie Kreider, Michael Obrecht, Shinji Hatakeyama, Christian Lambert, Manuela Flueckiger, Peter Richards
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Effects of repeated injection of monosodium urate (MSU) crystals, in combination with lipopolysaccharide (LPS), into rat knee joints every two weeks for a maximum of five administrations were investigated. Joint swelling, nociception and hard/soft ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41efec2f297d76e35a9329eb489e78cd
https://doi.org/10.21203/rs.3.rs-758047/v1
https://doi.org/10.21203/rs.3.rs-758047/v1
Autor:
Strang Ross Sinclair, Markus Streiff, Daniel J. McKay, Johannes Ottl, Andreas Billich, Claudia Betschart, Stephanie Harlfinger, Eloísa Jiménez-Núñez, Nigel Graham Cooke, Christine Guntermann, Markus Voegtle, Janet Dawson, Samuel Hintermann, Klemens Kaupmann, Rowan Stringer, Christian Beerli, Nathalie Gobeau, Juergen Wagner, Klemens Hoegenauer, Joerg Kallen, Peter Ertl
Publikováno v:
Journal of Medicinal Chemistry. 62:10816-10832
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) is considered to be the master transcription factor for the development of Th17 cells that produce proinflammatory cytokines such as IL-17A. Overproportionate Th17 cell abundance is asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1edf6050ac20e08d84ef25cb7a5c6f4c
https://doi.org/10.1021/acs.jmedchem.9b01291
https://doi.org/10.1021/acs.jmedchem.9b01291