Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Janet D, Siliciano"'
Autor:
Victoria E. K. Walker-Sperling, Noe B. Mercado, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola, Mark Lewis, Jeffrey P. Murry, Yunling Yang, Romas Geleziunas, Merlin L. Robb, Nelson L. Michael, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Dan H. Barouch
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Antiretroviral therapy alone is insufficient in curing HIV-1 infection, due to latent viral reservoir persistency. Here, authors explore the post-virologic control of combining active and passive immunisation with vesatolimod, in a SHIV-infected rhes
Externí odkaz:
https://doaj.org/article/3d61c11904ca4bafb0acb1d4d9eb6212
Autor:
Jennifer A. White, Fengting Wu, Saif Yasin, Milica Moskovljevic, Joseph Varriale, Filippo Dragoni, Angelica Camilo-Contreras, Jiayi Duan, Mei Y. Zheng, Ndeh F. Tadzong, Heer B. Patel, Jeanelle Mae C. Quiambao, Kyle Rhodehouse, Hao Zhang, Jun Lai, Subul A. Beg, Michael Delannoy, Christin Kilcrease, Christopher J. Hoffmann, Sébastien Poulin, Frédéric Chano, Cécile Tremblay, Jerald Cherian, Patricia Barditch-Crovo, Natasha Chida, Richard D. Moore, Michael F. Summers, Robert F. Siliciano, Janet D. Siliciano, Francesco R. Simonetti
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 6 (2023)
Background Antiretroviral therapy (ART) halts HIV-1 replication, decreasing viremia to below the detection limit of clinical assays. However, some individuals experience persistent nonsuppressible viremia (NSV) originating from CD4+ T cell clones car
Externí odkaz:
https://doaj.org/article/ef49646c2a614ed590cf85b7b8881c2b
Autor:
John D. Ventura, Joseph P. Nkolola, Abishek Chandrashekar, Erica N. Borducchi, Jinyan Liu, Noe B. Mercado, David L. Hope, Victoria M. Giffin, Katherine McMahan, Romas Geleziunas, Jeffrey P. Murry, Yunling Yang, Mark G. Lewis, Maria G. Pau, Frank Wegmann, Hanneke Schuitemaker, Emily J. Fray, Mithra R. Kumar, Janet D. Siliciano, Robert F. Siliciano, Merlin L. Robb, Nelson L. Michael, Dan H. Barouch
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure research. In this study, we investigated the therapeutic efficacy of a vaccine consisti
Externí odkaz:
https://doaj.org/article/e42cb38a5f4c44cdb752a66e3a3f759b
Autor:
Jennifer A White, Joshua T Kufera, Niklas Bachmann, Weiwei Dai, Francesco R Simonetti, Ciara Armstrong, Jun Lai, Subul Beg, Janet D Siliciano, Robert F Siliciano
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010845 (2022)
Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the persistence of a latent viral reservoir in resting CD4+ T cells. This reservoir is a major barrier to cure. Sequencing studies have revealed that the p
Externí odkaz:
https://doaj.org/article/90c900152949401b8709754fb7fb5878
Autor:
Daniel I S Rosenbloom, Peter Bacchetti, Mars Stone, Xutao Deng, Ronald J Bosch, Douglas D Richman, Janet D Siliciano, John W Mellors, Steven G Deeks, Roger G Ptak, Rebecca Hoh, Sheila M Keating, Melanie Dimapasoc, Marta Massanella, Jun Lai, Michele D Sobolewski, Deanna A Kulpa, Michael P Busch, Reservoir Assay Validation and Evaluation Network (RAVEN) Study Group
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 4, p e1006849 (2019)
Quantitative viral outgrowth assays (QVOA) use limiting dilutions of CD4+ T cells to measure the size of the latent HIV-1 reservoir, a major obstacle to curing HIV-1. Efforts to reduce the reservoir require assays that can reliably quantify its size
Externí odkaz:
https://doaj.org/article/b5955aac1a054bdaae557617f2bee089
Autor:
Helen L. Wu, Kathleen Busman-Sahay, Whitney C. Weber, Courtney M. Waytashek, Carla D. Boyle, Katherine B. Bateman, Jason S. Reed, Joseph M. Hwang, Christine Shriver-Munsch, Tonya Swanson, Mina Northrup, Kimberly Armantrout, Heidi Price, Mitch Robertson-LeVay, Samantha Uttke, Mithra R. Kumar, Emily J. Fray, Sol Taylor-Brill, Stephen Bondoc, Rebecca Agnor, Stephanie L. Junell, Alfred W. Legasse, Cassandra Moats, Rachele M. Bochart, Joseph Sciurba, Benjamin N. Bimber, Michelle N. Sullivan, Brandy Dozier, Rhonda P. MacAllister, Theodore R. Hobbs, Lauren D. Martin, Angela Panoskaltsis-Mortari, Lois M.A. Colgin, Robert F. Siliciano, Janet D. Siliciano, Jacob D. Estes, Jeremy V. Smedley, Michael K. Axthelm, Gabrielle Meyers, Richard T. Maziarz, Benjamin J. Burwitz, Jeffrey J. Stanton, Jonah B. Sacha
Publikováno v:
Immunity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93b382225fa6efa51126f59c14a8877a
https://doi.org/10.1016/j.immuni.2023.04.019
https://doi.org/10.1016/j.immuni.2023.04.019
Autor:
Weiwei Dai, Fengting Wu, Natalie McMyn, Bicna Song, Victoria E. Walker-Sperling, Joseph Varriale, Hao Zhang, Dan H. Barouch, Janet D. Siliciano, Wei Li, Robert F. Siliciano
Publikováno v:
Sci Transl Med
Reversing HIV-1 latency promotes killing of infected cells and is essential for cure strategies; however, no single latency reversing agent (LRA) or LRA combination have been shown to reduce HIV-1 latent reservoir size in persons living with HIV-1 (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e219f90c97a915002bf67692ca166edc
https://pubmed.ncbi.nlm.nih.gov/36260688
https://pubmed.ncbi.nlm.nih.gov/36260688
Autor:
Timothy J Henrich, Hiroyu Hatano, Oliver Bacon, Louise E Hogan, Rachel Rutishauser, Alison Hill, Mary F Kearney, Elizabeth M Anderson, Susan P Buchbinder, Stephanie E Cohen, Mohamed Abdel-Mohsen, Christopher W Pohlmeyer, Remi Fromentin, Rebecca Hoh, Albert Y Liu, Joseph M McCune, Jonathan Spindler, Kelly Metcalf-Pate, Kristen S Hobbs, Cassandra Thanh, Erica A Gibson, Daniel R Kuritzkes, Robert F Siliciano, Richard W Price, Douglas D Richman, Nicolas Chomont, Janet D Siliciano, John W Mellors, Steven A Yukl, Joel N Blankson, Teri Liegler, Steven G Deeks
Publikováno v:
PLoS Medicine, Vol 14, Iss 11, p e1002417 (2017)
BackgroundIt is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited from a pre-exposure prophylaxis (PrEP) program who started pro
Externí odkaz:
https://doaj.org/article/7146700700d742c7a0dd1a56e69b9226
Autor:
Emily J. Fray, Fengting Wu, Francesco R. Simonetti, Carolin Zitzmann, Narmada Sambaturu, Carmen Molina-Paris, Alexandra M. Bender, Po-Ting Liu, John D. Ventura, Roger W. Wiseman, David H. O’Connor, Romas Geleziunas, Thomas Leitner, Ruy M. Ribeiro, Alan S. Perelson, Dan H. Barouch, Janet D. Siliciano, Robert F. Siliciano
Publikováno v:
Cell Host & Microbe. 31:356-372.e5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e75f49a374a2a4dac41a42594887e21
https://doi.org/10.1016/j.chom.2023.01.016
https://doi.org/10.1016/j.chom.2023.01.016
Autor:
Robert F. Siliciano, Dorry L. Segev, Gregory M. Laird, Alexandra M. Bender, Sander Florman, Kyungyoon J. Kwon, Craig Martens, Alyssa R. Martin, Briana A. Lynch, Thomas C. Quinn, Aaron A.R. Tobian, Christine M. Durand, Jada Hackman, Daniel Bruno, Janet D. Siliciano, Niraj M. Desai, Subul A. Beg, Andrew D. Redd
Publikováno v:
J Infect Dis
Background The human immunodeficiency virus (HIV)-1 latent reservoir (LR) in resting CD4+ T cells is a barrier to cure. LR measurements are commonly performed on blood samples and therefore may miss latently infected cells residing in tissues, includ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94f65a5de2b435a0a3b0b1462046b93
https://doi.org/10.1093/infdis/jiaa736
https://doi.org/10.1093/infdis/jiaa736