Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Janet C. Wanstall"'
Publikováno v:
British Journal of Pharmacology. 143:63-70
1. The aim was to test the hypothesis that nitric oxide (NO) donor drugs can inhibit the 5-hydroxytryptamine (5-HT) transporter, SERT. 2. The NO donors, MAHMA/NO (a NONOate; (Z)-1-[N-methyl-N-[6-(N-methylammoniohexyl)-amino]]diazen-1-ium-1,2-diolate)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab846248cc9c45c7977ee1f5e2ba4e43
https://doi.org/10.1038/sj.bjp.0705904
https://doi.org/10.1038/sj.bjp.0705904
Autor:
Janet C. Wanstall, Agatha Gambino
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 17:97-103
Proteinase-activated receptor (PAR)-mediated vasorelaxant responses were examined in main pulmonary artery preparations from control rats and rats exposed to hypoxia (10% oxygen) for 1 or 4 weeks to induce pulmonary hypertension. Trypsin and the PAR-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211ada25762262943e14950e655a0db2
https://doi.org/10.1016/j.pupt.2003.11.002
https://doi.org/10.1016/j.pupt.2003.11.002
Autor:
Sheila A Doggrell, Janet C. Wanstall
Publikováno v:
Cardiovascular Research. 61:653-662
Chymase is a chymotrypsin-like serine protease secreted from mast cells. Mammalian chymases are classified into two subgroups (alpha and beta) according to structure and substrate specificity; human chymase is an alpha-chymase. An important action of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d02ca95a7a4eb2049619a59abe208f
https://doi.org/10.1016/j.cardiores.2003.11.029
https://doi.org/10.1016/j.cardiores.2003.11.029
Autor:
Bronwyn J. Thomas, Janet C. Wanstall
Publikováno v:
European Journal of Pharmacology. 477:153-161
Vasoactive agents were examined in arteries from control rats and rats exposed to intermittent hypoxia (10% oxygen; 8 h/day) for 3, 5 or 20 days. Hypoxic rats developed right ventricular hypertrophy after 5 days, but became pulmonary hypertensive (el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944c8036a7b4d16c16872c9dece92743
https://doi.org/10.1016/j.ejphar.2003.08.015
https://doi.org/10.1016/j.ejphar.2003.08.015
Will chymase inhibitors be the next major development for the treatment of cardiovascular disorders?
Autor:
Sheila A Doggrell, Janet C. Wanstall
Publikováno v:
Expert Opinion on Investigational Drugs. 12:1429-1432
Chymase is contained in the secretory granules of mast cells. In addition to the synthesis of angiotensin II, chymase is involved in transforming growth factor-beta activation and cleaves Type I procollagen to produce collagen. NK301 and BCEAB are or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094434b6d833ff021c48de7dc1c329e3
https://doi.org/10.1517/13543784.12.8.1429
https://doi.org/10.1517/13543784.12.8.1429
Publikováno v:
Journal of Pharmacy and Pharmacology. 55:1121-1125
The effects of S-nitrosocaptopril (SNOcap), administered either intravenously or by oral gavage, on pulmonary artery pressure (PAP) were examined in anaesthetised normotensive rats and rats with hypoxic pulmonary hypertension (10% oxygen for 1 week).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4ed1a685727c04bcdc4d421ad0e6317
https://doi.org/10.1211/0022357021369
https://doi.org/10.1211/0022357021369
Publikováno v:
British Journal of Pharmacology. 138:855-864
1 On rat isolated pulmonary arteries, vasorelaxation by S-nitrosocaptopril (SNOcap) was compared with S-nitrosoglutathione (GSNO) and nitroprusside, and inhibition by SNOcap of contractions to angiotensin I was compared with the angiotensin convertin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61834bea94260767563dce8e43527f25
https://doi.org/10.1038/sj.bjp.0705128
https://doi.org/10.1038/sj.bjp.0705128
Autor:
Janet C. Wanstall, Kerry L. Homer
Publikováno v:
British Journal of Pharmacology. 137:1071-1081
1. Inhibition of rat platelet aggregation by the nitric oxide (NO) donor MAHMA NONOate (Z-1-N-methyl-N-[6-(N-methylammoniohexyl)amino]diazen-1-ium-1,2-diolate) was investigated. The aims were to compare its anti-aggregatory effect with vasorelaxation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d86fc9372b387a4fdd273f250982e43
https://doi.org/10.1038/sj.bjp.0704971
https://doi.org/10.1038/sj.bjp.0704971
Autor:
Nicholas K. Hayward, Agatha Gambino, Marian M. Cahill, Janet C. Wanstall, Daniela Bellomo, Trina K Jeffery, Graham F. Kay
Publikováno v:
Cardiovascular Research. 55:361-368
Objective : To test the hypothesis that Vegf-B contributes to the pulmonary vascular remodelling, and the associated pulmonary hypertension, induced by exposure of mice to chronic hypoxia. Methods : Right ventricular systolic pressure, the ratio of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0874e8574e4ef8c55cfe0a29ef31b1a4
https://doi.org/10.1016/s0008-6363(02)00440-6
https://doi.org/10.1016/s0008-6363(02)00440-6
Publikováno v:
British Journal of Pharmacology. 134:463-472
1. Vasorelaxant properties of three nitric oxide (NO) donor drugs (glyceryl trinitrate, sodium nitroprusside and spermine NONOate) in mouse aorta (phenylephrine pre-contracted) were compared with those of endothelium-derived NO (generated with acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d913748dc38feeb0bb4d65d41fdf5f94
https://doi.org/10.1038/sj.bjp.0704269
https://doi.org/10.1038/sj.bjp.0704269