Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Janet C. Gilliland"'
Autor:
Ashit Trivedi, Bernd Meibohm, David F. Bruhn, Michael R. McNeil, Marcus M. Maddox, Michael S. Scherman, Rakesh, Dora B. Madhura, Lei Yang, Robin B. Lee, Anne J. Lenaerts, Richard E. Lee, Janet C. Gilliland, Veronica Gruppo
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:6063-6072
A series of tetracyclic nitrofuran isoxazoline anti-tuberculosis agents was designed and synthesized to improve the pharmacokinetic properties of an initial lead compound, which had potent anti-tuberculosis activity but suffered from poor solubility,
Autor:
Anne J. Lenaerts, Janet C. Gilliland, Ian M. Orme, Mary Ann De Groote, Veronica Gruppo, Lisa K. Woolhiser
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:731-738
In preclinical testing of antituberculosis drugs, laboratory-adapted strains of Mycobacterium tuberculosis are usually used both for in vitro and in vivo studies. However, it is unknown whether the heterogeneity of M. tuberculosis stocks used by vari
Autor:
Elizabeth J. Brooks, Scott M. Irwin, Janet C. Gilliland, Michael S. Scherman, Martin I. Voskuil, Rachel L. Leistikow, Eric L. Nuermberger, Veronica Gruppo, Matthew J. Reichlen, Anne J. Lenaerts, Igor Kramnik
Publikováno v:
Antimicrobial agents and chemotherapy. 58(7)
New drugs and drugs with a novel mechanism of action are desperately needed to shorten the duration of tuberculosis treatment, to prevent the emergence of drug resistance, and to treat multiple-drug-resistant strains of Mycobacterium tuberculosis . R
Autor:
Lonji Kalombo, L.H. du Plessis, Laetitia Booysen, Boitumelo Semete-Makokotlela, Elizabeth J. Brooks, Anne J. Lenaerts, R. Hansen, A.F Kotzé, Veronica Gruppo, Janet C. Gilliland, P. Lungenhofer, Hulda Swai
Poly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229 ± 7.6 to 382 ± 23.9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::841e9bbaba7e790a605f30aaac7900a1
https://hdl.handle.net/10394/14112
https://hdl.handle.net/10394/14112
Autor:
Janet C. Gilliland, Mary Ann DeGroote, Colby L. Wells, Veronica Gruppo, Ian M. Orme, Lisa K. Woolhiser, Anne J. Lenaerts
Publikováno v:
A55. MULTI-DRUG RESISTANT AND EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS.
Autor:
Elizabeth R, Magden, Cristina M, Weiner, Janet C, Gilliland, Mary Ann, DeGroote, Anne J, Lenaerts, Lon V, Kendall
Publikováno v:
Journal of the American Association for Laboratory Animal Science : JAALAS. 50(2)
Female BALB/cAnNCrl (n = 170; age, 6 to 9 wk) mice were infected by intravenous inoculation of 5 × 10(6) cfu Mycobacterium tuberculosis strain Erdman (ATCC 35801). Between day 52 and 5 mo after infection, 10 of the 170 mice infected according to thi
Autor:
Colby L. Wells, Mary Ann De Groote, Veronica Gruppo, Anne J. Lenaerts, Charles A. Peloquin, Elizabeth J. Brooks, Lisa K. Woolhiser, Janet C. Gilliland, Ian M. Orme
Publikováno v:
Antimicrobial agents and chemotherapy. 55(3)
Methodologies for preclinical animal model testing of drugs against Mycobacterium tuberculosis vary from laboratory to laboratory; however, it is unknown if these variations result in different outcomes. Thus, a series of head-to-head comparisons of