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Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias

Autor: Jacqueline Greer, Judith E. Karp, Dwella Moton-Nelson, Biju Joseph, Steven D. Gore, Hetty E. Carraway, Amanda L. Blackford, John J. Wright, Katrina Alino, Linda S. Resar, Janet Briel, Michael A. McDevitt, B. Douglas Smith, Mark J. Levis, Karen Mackey, L. Austin Doyle, Lorena Bagain, Ming Zhao, Michelle A. Rudek

Publikováno v: Blood. 117:3302-3310

Flavopiridol is a protein bound, cytotoxic, cyclin-dependent kinase inhibitor. Flavopiridol given by 1-hour bolus at 50 mg/m2 daily 3 times followed by cytosine arabinoside and mitoxantrone (FLAM) is active in adults with poor-risk acute leukemias. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dffa59c85be1a51405eec7aee2ca237
https://doi.org/10.1182/blood-2010-09-310862

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Early lymphocyte recovery after intensive timed sequential chemotherapy for acute myelogenous leukemia: peripheral oligoclonal expansion of regulatory T cells

Autor: Christopher J. Thoburn, Leo Luznik, Christopher D. Gocke, Janet Briel, B. Douglas Smith, Christian F. Meyer, Christopher G. Kanakry, Judith E. Karp, Ferdynand Kos, Allan D. Hess, Hyam I. Levitsky

Publikováno v: Blood. 117:608-617

Few published studies characterize early lymphocyte recovery after intensive chemotherapy for acute myelogenous leukemia (AML). To test the hypothesis that lymphocyte recovery mirrors ontogeny, we characterized early lymphocyte recovery in 20 consecu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c0aedc549cd15d4b2d29b823423262
https://doi.org/10.1182/blood-2010-04-277939

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Sequential Flavopiridol, Cytosine Arabinoside, and Mitoxantrone: A Phase II Trial in Adults with Poor-Risk Acute Myelogenous Leukemia

Autor: B. Douglas Smith, Janet Briel, Jacqueline Greer, Judith E. Karp, Mark J. Levis, Steven D. Gore, John J. Wright, A. Dimitri Colevas, Catherine Hattenburg, Richard J. Jones

Publikováno v: Clinical Cancer Research. 13:4467-4473

Purpose: Flavopiridol is a cyclin-dependent kinase inhibitor that is cytotoxic to leukemic blasts. In a phase I study of flavopiridol followed by 1-β-d-arabinofuranosylcytosine (ara-C) and mitoxantrone, overall response rate for adults with relapsed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5694d24f9bbb2d81d9eaa93cfd8ec555
https://doi.org/10.1158/1078-0432.ccr-07-0381

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A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias

Autor: Michael A. McDevitt, Hetty E. Carraway, B. Douglas Smith, Kumudha Balakrishnan, Jacqueline Greer, Rebecca M. Ricklis, Steven D. Gore, Mark J. Levis, Varsha Gandhi, Judith E. Karp, Janet Briel

Clofarabine has shown impressive response rates in patients with acute leukemias. In vitro investigations with clofarabine in combination with cyclophosphamide in primary cells have demonstrated synergistic cytotoxicity and inhibition of DNA repair.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe472b8784c45367025a7a9fff1029b
https://europepmc.org/articles/PMC1976362/

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Characterization of Immune Reconstitution Following High Dose Chemotherapy in Acute Myeloid Leukemia

Autor: Allan D. Hess, Christopher J. Thoburn, Janet Briel, Christopher D. Gocke, Christian F. Meyer, Judith E. Karp, Ferdynand Kos, Hyam I. Levitsky

Publikováno v: Blood. 110:3888-3888

Recovery of immune function after initial treatment of acute myeloid leukemia (AML) is critical, not only for protection against infections but also for surveillance against recurrent disease. A better understanding of the nature of lymphocyte recove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::979ad7aa39bf2a3810d366b1b20591f5
https://doi.org/10.1182/blood.v110.11.3888.3888

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Phase I Clinical-Laboratory Trial of Clofarabine (CLO) Followed by Cyclophosphamide (CY) for Adults with Refractory Acute Leukemias: Evidence for Enhanced DNA Damage

Autor: Rebecca M. Ricklis, Mark J. Levis, Judith E. Karp, Jacqueline Greer, Janet Briel

Publikováno v: Blood. 108:1963-1963

CLO is a nucleoside analog with ribonucleotide reductase inhibitory activity. As such, CLO has the ability to impede repair of damaged DNA. We designed a Phase I clinical trial of CLO followed by CY for adults with refractory acute leukemias, with es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d753b0b40c5f279c43a075984376abb3
https://doi.org/10.1182/blood.v108.11.1963.1963

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Phase II Clinical Trial of Flavopiridol (FL) Followed by ara-c and Mitoxantrone (AM) for Adults with Relapsed and Refractory Acute Leukemias

Autor: Janet Briel, A. Dimitrios Colevas, Steven D. Gore, Mark J. Levis, Michael A. McDevitt, Jacqueline Greer, Judith E. Karp, B. Douglas Smith

Publikováno v: Blood. 106:2784-2784

The cell cycle inhibitor FL targets cyclin-dependent kinases, induces checkpoint arrest and interrupts transcriptional elongation. We demonstrated in an in vitro model that F causes apoptosis in leukemic blasts and increases A cytotoxicity in remaini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfcac4d0f36a1a45529b4f1a1f413935
https://doi.org/10.1182/blood.v106.11.2784.2784

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