Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Janet Beckmann"'
Autor:
Madalina V. Nastase, Janet Beckmann, Louise Tzung Harn Hsieh, Jan Mersmann, Josef Pfeilschifter, Chiara Poluzzi, Liliana Schaefer, Renato V. Iozzo, Jaime Lopez-Mosqueda, Fumiyo Ikeda, Jinyang Zeng-Brouwers, Ivan Dikic, Nina Schroeder, Helena Frey
Publikováno v:
The American Journal of Pathology. 186:1206-1220
Sepsis is burdened by high mortality due to uncontrolled inflammatory response to pathogens. Increased caspase 1 activation causing maturation of IL1β/18 remains a therapeutic challenge in sepsis. SHARPIN (shank-associated regulator of G-protein sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e8c483b3567b3e7f6ea515c8e88d3f
https://doi.org/10.1016/j.ajpath.2015.12.026
https://doi.org/10.1016/j.ajpath.2015.12.026
Autor:
Claudia Tredup, Heinfried H. Radeke, Jinyang Zeng-Brouwers, Janet Beckmann, Urs Christen, Malgorzata Wygrecka, Madalina V. Nastase, Liliana Schaefer
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology.
Th1 and Th17 cells, T helper (Th) subtypes, are key inducers of renal fibrosis. The molecular mechanisms of their recruitment into the kidney, however, are not well understood. Here, we show that biglycan, a proteoglycan of the extracellular matrix,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd68eb8dd8c6395663ba45c590194db
https://pubmed.ncbi.nlm.nih.gov/29253517
https://pubmed.ncbi.nlm.nih.gov/29253517
Autor:
Hans-Georg Morhenn, Katrin S. Lips, Reinhard Schnettler, Janet Beckmann, Jan Schubert, Veronika Grau
Publikováno v:
Cell and Tissue Research
Increasing evidence is showing that the non-neuronal cholinergic system plays an important role in the pathology of rheumatoid arthritis (RA). Choline transport into the cell is the rate-limiting step for the synthesis of acetylcholine (ACh), which c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866c626eddf7089c7ccadd776c9cf8da
http://europepmc.org/articles/PMC4320306
http://europepmc.org/articles/PMC4320306
Autor:
Katrin S. Lips, Janet Beckmann
Publikováno v:
Pharmacology. 92:286-302
Acetylcholine (ACh) is not only a neurotransmitter but is an ancient molecule that can be released by and act on non-neuronal cells. In these cells the system of ACh-synthesizing enzymes, transporters, receptors and degrading enzymes is termed the no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612b65a5da1dfa8985a9ab73fa271745
https://doi.org/10.1159/000355835
https://doi.org/10.1159/000355835
Autor:
Elad Moisseiev, Katrin S. Lips, Rahul Singh, Kent E. Vrana, A. Benvenuto, Ai-Qi Zhang, Suzhe Liu, Spinello Antinori, Tetsuo Nakata, G. Speziale, Hong Liu, Druckerei Stückle, Margherita Padeletti, Sergio Mondillo, Mee Jeong Lee, Guijuan Feng, Shujin Wu, F. Buta, Qingshan Yang, Qiyun Tang, Harjeet Kaur, Fangxin Huo, Jinxia Jiang, Janet Beckmann, Izel Tekin, Yu-Jing Zhang, Anna Maria Peri, G. Meliota, Kanupriya Vashishth, Shiri Zayit-Soudri, Xiang Gao, Eliya Levinger, F. Massari, Makoto Ohigashi, Jing Xing, Adiel Barak, Michael Waisbourd, Laura Milazzo, Sanja Jelic, Hiroe Toba, David Varssano, P. Saracino, C. Tsioulpas, Shehua Yang, Liying Liu, Zhifeng Gu, Massimo Maccherini, Valerio Zacà, Liren Li, Li Yao, Sonia Bernazzali, Bikash Medhi, Aixian Zhang, Bin Ge, Dario Cattaneo, Wei Tan, Yue Xu, Simone Vidale, Miyuki Kobara, Carlo Alberto Magni, Cristina Gervasoni, Anat Loewenstein, Zhi-Liang Tian, Ajay Prakash, Irina Barequet, Maria Caputo, Xia-Xia Zhao, Felicia Stefania Falvella, G. Riccioni, L. Masciocco, D. De Viti, Jiahong Wang
Publikováno v:
Pharmacology. 92:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91793b6b2ba73e71be777fbe6425dad3
https://doi.org/10.1159/000357724
https://doi.org/10.1159/000357724
Publikováno v:
Arthritis Research & Therapy
Background There is increasing evidence that the non-neuronal cholinergic system might be of importance for the pathology of rheumatoid arthritis. The role of M3 muscarinic acetylcholine receptor (M3R) in this regard has, however, not been investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a2f54effbc5ce4649ba7059cb8c4b4c
https://pubmed.ncbi.nlm.nih.gov/26785775
https://pubmed.ncbi.nlm.nih.gov/26785775
Autor:
Renato V. Iozzo, Madalina-Viviana Nastase, Jinyang Zeng-Brouwers, Janet Beckmann, Liliana Schaefer
Publikováno v:
Matrix biology : journal of the International Society for Matrix Biology. 35
Matrix-bound constituents, such as the small leucine-rich proteoglycan biglycan, can act as powerful signaling molecules when released by limited proteolysis of the extracellular matrix or de novo synthesized by macrophages in the circulation and bod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80866dbe5c618af89a445121258f456a
https://pubmed.ncbi.nlm.nih.gov/24361484
https://pubmed.ncbi.nlm.nih.gov/24361484
Autor:
Narayana Anilkumar, Oliver Jung, Christian Fork, Andrea Babelova, Ajay M. Shah, Liliana Schaefer, Janet Beckmann, Despina Avaniadi, Judith Kosowski, Ralf P. Brandes, Norbert Weissmann, Katrin Schröder
Publikováno v:
Free radical biologymedicine. 53(4)
Nox4 is a hydrogen peroxide-producing NADPH oxidase highly expressed in the kidney which has been linked to epithelial cell injury and diabetic-induced cellular dysfunction in cultured cells. The role of the enzyme for renal pathology in vivo, howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f0b9f099533e5db653202c068110f1
https://pubmed.ncbi.nlm.nih.gov/22749956
https://pubmed.ncbi.nlm.nih.gov/22749956
Autor:
Hans-Georg Morhenn, Katrin S. Lips, Jan Schubert, Gabor Szalay, Reinhard Schnettler, Christian Heiss, Sonja Hartmann, Janet Beckmann
Publikováno v:
Life sciences. 91(21-22)
Aims As the stimulation of the α7-nicotinic acetylcholine receptor (nAChR), which is present in the synovium of patients with rheumatoid arthritis (RA), leads to a decrease in pro-inflammatory cytokines, the α7-nAChR is being discussed as a new the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2880dd8af54f9d5579c8102bd7f53a3c
https://pubmed.ncbi.nlm.nih.gov/22569293
https://pubmed.ncbi.nlm.nih.gov/22569293
Autor:
Janet Beckmann, Mohamed S. Abdel-Bakky, Anke Doller, Paul Gutwein, Abdel-Aziz H. Abdel-Aziz, Kerstin Amann, Josef Pfeilschifter, Anja Schramme, El Sayed M. El Sayed, Kai Doberstein, Liliana Schaefer, Nicole Kämpfer-Kolb
Publikováno v:
Journal of Cellular and Molecular Medicine
Diabetic nephropathy (DN) is a major cause of end-stage renal failure worldwide. Oxidative stress has been reported to be a major culprit of the disease and increased oxidized low density lipoprotein (oxLDL) immune complexes were found in patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e6d2a8d1875591d4e073162f224d83
https://pubmed.ncbi.nlm.nih.gov/19426159
https://pubmed.ncbi.nlm.nih.gov/19426159