The antitumor effect induced by an IL-2 ‘no-alpha’ mutein depends on changes in the CD8+ T lymphocyte/Treg cell balance

Autor: Tania Carmenate, Galia Montalvo, Sum Lai Lozada, Yaretnis Rodriguez, Yaquelin Ortiz, Claudia Díaz, Janet Avellanet, Juhee Kim, Charles D. Surh, Luis Graça, Kalet León

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

High doses of interleukin-2 (IL-2) have been used for the treatment of melanoma and renal cell carcinoma, but this therapy has limited efficacy, with a ~15% response rate. Remarkably, 7%–9% of patients achieve complete or long-lasting responses. Ma

Externí odkaz: https://doaj.org/article/db353f693edd4261946930a857c34c5b

Efficacy of direct current generated by multiple-electrode arrays on F3II mammary carcinoma: experiment and mathematical modeling

Autor: Leonardo Mesa Torres, Mayrel Labrada Mon, Héctor Manuel Camué Ciria, Enaide Maine Calzado, Victoriano Gustavo Sierra González, Antonio Rafael Selva Castañeda, Kalet León Monzón, Jorge Luis García Rodríguez, Oscar Ortiz Posada, Daniel Jay Pérez, Arlem García Delgado, Luis Enrique Bergues Cabrales, Narciso Antonio Villar Goris, Karina García Martínez, Maraelys Morales González, Beatriz Olivares Borges, Dasha Fuentes Morales, Juan I. Montijano, Janet Avellanet Martínez

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-17 (2020)
Journal of Translational Medicine

Background The modified Gompertz equation has been proposed to fit experimental data for direct current treated tumors when multiple-straight needle electrodes are individually inserted into the base perpendicular to the tumor long axis. The aim of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca53ca6fcb1320db2bd4db55955baea7
http://zaguan.unizar.es/record/89658

Blocking IL-2 Signal In Vivo with an IL-2 Antagonist Reduces Tumor Growth through the Control of Regulatory T Cells

Autor: Tania Carmenate, Kalet León, Karina García-Martínez, Luis Graca, Michel Enamorado, Ernesto Moreno, Janet Avellanet, Yaquelín Ortiz

Publikováno v: The Journal of Immunology. 200:3475-3484

IL-2 is critical for peripheral tolerance mediated by regulatory T (Treg) cells, which represent an obstacle for effective cancer immunotherapy. Although IL-2 is important for effector (E) T cell function, it has been hypothesized that therapies bloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aceb6389f652be6440a3399e9f7651
https://doi.org/10.4049/jimmunol.1700433

Deciphering the molecular bases of the biological effects of antibodies against Interleukin-2: A versatile platform for fine epitope mapping

Autor: Sachdev S. Sidhu, Kalet León, Tania Carmenate, Janet Avellanet, Amaury Pupo, Gertrudis Rojas

Publikováno v: Immunobiology. 218:105-113

Elucidating the network of interactions established by Interleukin-2 is a key step to understanding its role as a master regulator of the immune system. Binding of this cytokine by specific antibodies gives rise to different classes of immune complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f3e8763cf00a850620921d3cc06d34
https://doi.org/10.1016/j.imbio.2012.02.009

Priming and boosting determinants on the antibody response to an Epidermal Growth Factor-based cancer vaccine

Autor: Adys Gonzalez, Armando López, Ileana Gonzalez, Janet Avellanet, Agustin Lage, Pedro C. Rodriguez, Rolando Pérez, Enrique Montero

Publikováno v: Vaccine. 26:4647-4654

Epidermal Growth Factor chemically conjugated to P64k carrier protein from Neisseria meningitidis emulsified in Montanide ISA 51 adjuvant is a cancer vaccine under clinical evaluation. We explored the influence of priming and boosting variables on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517ba088890e2d2a2705792d9a2f6e13
https://doi.org/10.1016/j.vaccine.2008.07.003