Zobrazeno 1 - 10
of 156
pro vyhledávání: '"Janet A. Young"'
Publikováno v:
Journal of Teaching and Learning for Graduate Employability, Vol 15, Iss 1 (2024)
Change in the workplace is inevitable, intensified by the rapid development of global markets and demand for highly skilled and adaptable employees. One response to this demand is for higher degree students to immerse in workplace experiences aligned
Externí odkaz:
https://doaj.org/article/82aa6845f2fc4e92b76cecf3e5007a2f
Autor:
Joseph Hiatt, Judd F. Hultquist, Michael J. McGregor, Mehdi Bouhaddou, Ryan T. Leenay, Lacy M. Simons, Janet M. Young, Paige Haas, Theodore L. Roth, Victoria Tobin, Jason A. Wojcechowskyj, Jonathan M. Woo, Ujjwal Rathore, Devin A. Cavero, Eric Shifrut, Thong T. Nguyen, Kelsey M. Haas, Harmit S. Malik, Jennifer A. Doudna, Andrew P. May, Alexander Marson, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Hiatt et al. report the knock-out of over 400 genes in primary CD4+ T cells to assess their functional role in HIV replication, finding 86 initial candidates of which 47 are validated as HIV host factors, including 23 with restrictive activity.
Externí odkaz:
https://doaj.org/article/4afe586db1e74b9e9e49556512d17fd5
Autor:
Courtney M Schroeder, Sarah A Tomlin, Isabel Mejia Natividad, John R Valenzuela, Janet M Young, Harmit S Malik
Publikováno v:
eLife, Vol 10 (2021)
Most actin-related proteins (Arps) are highly conserved and carry out well-defined cellular functions in eukaryotes. However, many lineages like Drosophila and mammals encode divergent non-canonical Arps whose roles remain unknown. To elucidate the f
Externí odkaz:
https://doaj.org/article/66f339a7be314fdaa5bcaa648a184beb
Autor:
Bhavatharini Kasinathan, Serafin U Colmenares III, Hannah McConnell, Janet M Young, Gary H Karpen, Harmit S Malik
Publikováno v:
eLife, Vol 9 (2020)
Contrary to dogma, evolutionarily young and dynamic genes can encode essential functions. We find that evolutionarily dynamic ZAD-ZNF genes, which encode the most abundant class of insect transcription factors, are more likely to encode essential fun
Externí odkaz:
https://doaj.org/article/ff87ca4533974434b7eb2d974ade17fe
Publikováno v:
eLife, Vol 9 (2020)
Antagonistic coevolution with selfish genetic elements (SGEs) can drive evolution of host resistance. Here, we investigated host suppression of 2-micron (2μ) plasmids, multicopy nuclear parasites that have co-evolved with budding yeasts. We develope
Externí odkaz:
https://doaj.org/article/1a5101a2e73243609496308f497e23cc
Autor:
Piero Lamelza, Janet M Young, Luke M Noble, Lews Caro, Arielle Isakharov, Meenakshi Palanisamy, Matthew V Rockman, Harmit S Malik, Michael Ailion
Publikováno v:
PLoS Genetics, Vol 15, Iss 12, p e1008520 (2019)
Although most unicellular organisms reproduce asexually, most multicellular eukaryotes are obligately sexual. This implies that there are strong barriers that prevent the origin or maintenance of asexuality arising from an obligately sexual ancestor.
Externí odkaz:
https://doaj.org/article/3744df6ec82649c2bda135890a9f6d1c
Autor:
Rossana Colón-Thillet, Emily Hsieh, Laura Graf, Richard N McLaughlin, Janet M Young, Georg Kochs, Michael Emerman, Harmit S Malik
Publikováno v:
PLoS Biology, Vol 17, Iss 10, p e3000181 (2019)
Antagonistic interactions drive host-virus evolutionary arms races, which often manifest as recurrent amino acid changes (i.e., positive selection) at their protein-protein interaction interfaces. Here, we investigated whether combinatorial mutagenes
Externí odkaz:
https://doaj.org/article/17900a824db4486098fa966658ecc257
Autor:
Robert L. Vessella, Barbara J. Trask, Li Hsu, Janet M. Young, Lawrence D. True, William J. Ellis, Paul H. Lange, Peter S. Nelson, Jeffrey J. Delrow, Cassandra L. Sather, Todd M. Morgan, Ian S. Gallaher, Cynthia L. Friedman, Martin Kinnunen, Douglas I. Grove, Ilona N. Holcomb
Supplementary Table 4 from Genomic Alterations Indicate Tumor Origin and Varied Metastatic Potential of Disseminated Cells from Prostate Cancer Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640714a5c352f9441c286ea3dd44e7ee
https://doi.org/10.1158/0008-5472.22376663
https://doi.org/10.1158/0008-5472.22376663
Autor:
Barbara J. Trask, Robert L. Vessella, Peter S. Nelson, Celestia S. Higano, Colm M. Morrissey, Martine P. Roudier, Lawrence D. True, Li Hsu, Douglas I. Grove, Keyan Salari, Ilsa M. Coleman, Janet M. Young, Ilona N. Holcomb
Supplementary Tables 1-6 from Comparative Analyses of Chromosome Alterations in Soft-Tissue Metastases within and across Patients with Castration-Resistant Prostate Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae55badd60e27208af9241009e24174
https://doi.org/10.1158/0008-5472.22379561.v1
https://doi.org/10.1158/0008-5472.22379561.v1
Autor:
Robert L. Vessella, Barbara J. Trask, Li Hsu, Janet M. Young, Lawrence D. True, William J. Ellis, Paul H. Lange, Peter S. Nelson, Jeffrey J. Delrow, Cassandra L. Sather, Todd M. Morgan, Ian S. Gallaher, Cynthia L. Friedman, Martin Kinnunen, Douglas I. Grove, Ilona N. Holcomb
Supplementary Table 3 from Genomic Alterations Indicate Tumor Origin and Varied Metastatic Potential of Disseminated Cells from Prostate Cancer Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8506877387ab500fe9c7bc57942d1663
https://doi.org/10.1158/0008-5472.22376666
https://doi.org/10.1158/0008-5472.22376666