Zobrazeno 1 - 10
of 276
pro vyhledávání: '"Janet A. Willment"'
Autor:
Jennifer L. Reedy, Kirstine Nolling Jensen, Arianne J. Crossen, Kyle J. Basham, Rebecca A. Ward, Christopher M. Reardon, Hannah Brown Harding, Olivia W. Hepworth, Patricia Simaku, Geneva N. Kwaku, Kazuya Tone, Janet A. Willment, Delyth M. Reid, Mark H. T. Stappers, Gordon D. Brown, Jayaraj Rajagopal, Jatin M. Vyas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Respiratory infections caused by the human fungal pathogen Aspergillus fumigatus are a major cause of mortality for immunocompromised patients. Exposure to these pathogens occurs through inhalation, although the role of the respiratory epith
Externí odkaz:
https://doaj.org/article/e6887f3ec8884f338db33021a03541eb
Autor:
Rémi Hatinguais, Madalaine Kay, Fabián Salazar, Daniel P. Conn, David L. Williams, Peter C. Cook, Janet A. Willment, Gordon D. Brown
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Fc-C-type lectin receptor (Fc-CTLRs) probes are soluble chimeric proteins constituted of the extracellular domain of a CTLR fused with the constant fraction (Fc) of the human IgG. These probes are useful tools to study the interaction of CTL
Externí odkaz:
https://doaj.org/article/34801da1a3ac4dc2ac38ef8fe37b8eb5
Autor:
Gabriela W. P. Neves, Sarah Sze Wah Wong, Vishukumar Aimanianda, Catherine Simenel, J. Iñaki Guijarro, Catriona Walls, Janet A. Willment, Neil A. R. Gow, Carol A. Munro, Gordon D. Brown, Leila M. Lopes-Bezerra
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In this study, the human immune response mechanisms against Sporothrix brasiliensis and Sporothrix schenckii, two causative agents of human and animal sporotrichosis, were investigated. The interaction of S. brasiliensis and S. schenckii with human m
Externí odkaz:
https://doaj.org/article/bb4c4a4b11944c2dbe5e54c8ca580d0f
Autor:
Kazuya Tone, Mark H. T. Stappers, Remi Hatinguais, Ivy M. Dambuza, Fabián Salazar, Carol Wallace, Raif Yuecel, Petruta L. Morvay, Kazuyoshi Kuwano, Janet A. Willment, Gordon D. Brown
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Environmental factors, particularly fungi, influence the pathogenesis of allergic airway inflammation, but the mechanisms underlying these effects are still unclear. Melanin is one fungal component which is thought to modulate pulmonary inflammation.
Externí odkaz:
https://doaj.org/article/2dc87d39964f46f59290f2b8ae8998df
Autor:
Isabel Valsecchi, Emmanuel Stephen-Victor, Sarah Sze Wah Wong, Anupama Karnam, Margaret Sunde, J. Iñaki Guijarro, Borja Rodríguez de Francisco, Thomas Krüger, Olaf Kniemeyer, Gordon D. Brown, Janet A. Willment, Jean-Paul Latgé, Axel A. Brakhage, Jagadeesh Bayry, Vishukumar Aimanianda
Publikováno v:
Journal of Fungi, Vol 6, Iss 3, p 151 (2020)
Immune inertness of Aspergillusfumigatus conidia is attributed to its surface rodlet-layer made up of RodAp, characterized by eight conserved cysteine residues forming four disulfide bonds. Earlier, we showed that the conserved cysteine residue point
Externí odkaz:
https://doaj.org/article/0a7ad606191b4a8ea176a524647b608e
Publikováno v:
ERJ Open Research, Vol 4, Iss 2 (2018)
Aspergillus fumigatus infects up to 50% of cystic fibrosis (CF) patients and may play a role in progressive lung disease. As cystic fibrosis transmembrane conductance regulator is expressed in cells of the innate immune system, we hypothesised that i
Externí odkaz:
https://doaj.org/article/6876d50f000c456cab74085895f9d5eb
Autor:
Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af5e5562aa76972e639906507572102f
https://doi.org/10.7554/elife.83037.sa2
https://doi.org/10.7554/elife.83037.sa2
Publikováno v:
Parasite immunologyREFERENCES.
C-type lectin receptors (CLRs) constitute a category of innate immune receptors that play an essential role in the antifungal immune response. For over two decades, scientists have uncovered what are the fungal ligands recognized by CLRs and how thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471875fff94d7b58f86e86985732e908
https://pubmed.ncbi.nlm.nih.gov/36114607
https://pubmed.ncbi.nlm.nih.gov/36114607
Autor:
Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki
Publikováno v:
eLife
eLife, 2022, 11, ⟨10.7554/eLife.83037⟩
eLife, 2022, 11, ⟨10.7554/eLife.83037⟩
C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a02318862097f2bb560e179de5014e
https://doi.org/10.1101/2022.09.02.506356
https://doi.org/10.1101/2022.09.02.506356
Autor:
Janet A. Willment, Gordon D. Brown
Publikováno v:
Seminars in Immunology. 66:101734
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d309dc86ee771ab0c9dfce55fcae2175
https://doi.org/10.1016/j.smim.2023.101734
https://doi.org/10.1016/j.smim.2023.101734