Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Janet A. Houser"'
Autor:
Daniel P. Walker, Daniel W. Kung, Anil Mistry, Michael P. Zawistoski, Seungil Han, Jian-Cheng Li, Janet A. Houser, Jason Boer, Amy P. Baumann, Leonard Buckbinder, Molly A. McGlynn, Peter C. Bonnette, Angel Guzman-Perez, Li Xing
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3253-3258
The synthesis, in vitro properties, and in vivo pharmacokinetics for a series of sulfoximine-substituted trifluoromethylpyrimidines as inhibitors of proline-rich tyrosine kinase, a target for the possible treatment of osteoporosis, are described. The
The effect of rotation on the gravitational radiation and dynamical stability of stiff stellar cores
Autor:
Janet L. Houser
Publikováno v:
Monthly Notices of the Royal Astronomical Society. 299:1069-1086
Autor:
Janet A. Houser, Henry J. Showell, Caroline C. Whitacre, Glen Apseloff, Maryrose J. Conklyn, Arlene C Johnson, Keith D. Wilner, Theodore E. Liston
Publikováno v:
British Journal of Clinical Pharmacology. 45:115-121
Aims CP-105,696, (+)-1-(3S,4R)-[3-(4-phenylbenzyl)-4-hydroxy-chroman-7-yl] cyclopropane carboxylic acid is a potent, novel LTB4 receptor antagonist advanced to clinical trials to determine its efficacy in inflammatory diseases. The pharmacokinetics a
Autor:
Katherine Loomis, Kevin Daniel Freeman-Cook, Zhengrong Zhao, Susan Tapley, Dennis Paul Phillion, Richard L. Elliott, Steven B. Coffey, Christopher S. Jones, Kevin E. Henegar, Kirk McPherson, Chris Limberakis, Scott Bader, Janet A. Houser, Leanne M. Buzon, Angel Guzman-Perez, Shawn D. Doran, Wei Song, Betsy Pierce, Kendra Louise Nelson, Meihua Tu, William P. Esler, Kenneth J. DiRico, Sharad B. Murdande, Jeffrey W. Corbett, Paul A. Amor, Eliot Sugarman
Publikováno v:
Journal of medicinal chemistry. 55(2)
This paper describes the design and synthesis of a novel series of dual inhibitors of acetyl-CoA carboxylase 1 and 2 (ACC1 and ACC2). Key findings include the discovery of an initial lead that was modestly potent and subsequent medicinal chemistry op
Autor:
H. James Harwood, R. Kirk McPherson, Susan Tapley, Leanne M. Buzon, Kevin Daniel Freeman-Cook, Steven B. Coffey, Richard L. Elliott, Darcy Kohls, Liang Tong, Felix Vajdos, Meihua Tu, Eliot Sugarman, Shawn D. Doran, Francis Rajamohan, Eric S. Marr, Hailong Zhang, Wei Song, Kenneth J. DiRico, Jeffrey W. Corbett, Janet A. Houser, Sharad B. Murdande, William P. Esler, Martha L. Minich, Christopher J. Jones
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
Screening Pfizer's compound library resulted in the identification of weak acetyl-CoA carboxylase inhibitors, from which were obtained rACC1 CT-domain co-crystal structures. Utilizing HTS hits and structure-based drug discovery, a more rigid inhibito
Publikováno v:
Physical Review D. 65
We compare two advanced designs for gravitational-wave antennas in terms of their ability to detect two possible gravitational wave sources. Spherical, resonant mass antennas and interferometers incorporating resonant sideband extraction (RSE) were m
Autor:
Janet L. Houser
Publikováno v:
AIP Conference Proceedings.
Symmetry-breaking rotational instabilities may play a significant role in the dynamics of rapidly rotating compact objects. During the growth of such global non-axisymmetric instabilities, the external spacetime undergoes dynamical changes in respons
We have carried out 3-D numerical simulations of the dynamical bar instability in a rotating star and the resulting gravitational radiation using both an Eulerian code written in cylindrical coordinates and a smooth particle hydrodynamics (SPH) code.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cbeec6cfbfc91163bb1a947af6f2a1
http://arxiv.org/abs/gr-qc/9510014
http://arxiv.org/abs/gr-qc/9510014
We present the first calculations of the gravitational radiation produced by nonaxisymmetric dynamical instability in a rapidly rotating compact star. The star deforms into a bar shape, shedding $\sim 4\%$ of its mass and $\sim 17\%$ of its angular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ec5f1fd4e0955c54f7474c8fd34af9
http://arxiv.org/abs/gr-qc/9409057
http://arxiv.org/abs/gr-qc/9409057