Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

Autor: Jonathan D. Humphries, Junzhe Zha, Jessica Burns, Janet A. Askari, Christopher R. Below, Megan R. Chastney, Matthew C. Jones, Aleksandr Mironov, David Knight, Derek A. O'Reilly, Mark J. Dunne, David R. Garrod, Claus Jorgensen, Martin J. Humphries

Publikováno v: Matrix Biology. 110:16-39

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical intervention. Together with activatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bfee4f927422bbf2cde97522e154f49
https://doi.org/10.1016/j.matbio.2022.03.010

Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation

Autor: Jonathan D. Humphries, Martin J. Humphries, Matthew Jones, Junzhe Zha, Christopher R. Below, Alexander A. Mironov, David R. Garrod, David Knight, Derek A. O'Reilly, Claus Jørgensen, Megan R. Chastney, Janet A. Askari, Mark Dunne, Jessica Burns

Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis due to its aggressive progression, late detection and lack of druggable driver mutations, which often combine to result in unsuitability for surgical intervention. Together with activatin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f1158a21445e7b82aebc4d121a8cd53
https://doi.org/10.1101/2021.08.19.456969

FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

Autor: Martin J. Humphries, Paul N. Bishop, Nadhim Bayatti, Maja Søberg Udsen, Rawshan Choudhury, Viranga Tilakaratna, Selina McHarg, Richard Scharff, Ewa Szula, Simon J. Clark, Janet A. Askari

Publikováno v: Scientific Reports
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M, Mcharg, S, Askari, J, Humphries, M J, Bishop, P & Clark, S 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, no. 1, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Choudhury, R, Bayatti, N, Scharff, R, Szula, E, Tilakaratna, V, Udsen, M S, McHarg, S, Askari, J A, Humphries, M J, Bishop, P N & Clark, S J 2021, ' FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress ', Scientific Reports, vol. 11, 14175 . https://doi.org/10.1038/s41598-021-93708-5
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Retinal pigment epithelial (RPE) cells that underlie the neurosensory retina are essential for the maintenance of photoreceptor cells and hence vision. Interactions between the RPE and their basement membrane, i.e. the inner layer of Bruch’s membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd44c6c515f5cf3e410767874f2acb8
https://pubmed.ncbi.nlm.nih.gov/34239032

β1 integrin is a sensor of blood flow direction

Autor: Victoria Ridger, Antreas C. Kalli, Martin J. Humphries, Celine Souilhol, Hannah Roddie, Emmanuel Pinteaux, Jonathan P. Waltho, Jovana Serbanovic-Canic, Dhruv R. Shah, Ioannis Xanthis, Matthew T. Bryan, Raymond C.B. Wong, Nasreen Akhtar, Shuang Feng, Lindsay Canham, Janet A. Askari, Maria Fragiadaki, Paul C. Evans

Publikováno v: Xanthis, I, Souilhol, C, Serbanovic-canic, J, Roddie, H, Kalli, A C, Fragiadaki, M, Wong, R, Shah, D R, Askari, J A, Canham, L, Akhtar, N, Feng, S, Ridger, V, Waltho, J, Pinteaux, E, Humphries, M J, Bryan, M T & Evans, P C 2019, ' β1 integrin is a sensor of blood flow direction ', Journal of Cell Science . https://doi.org/10.1242/jcs.229542
Journal of Cell Science

Endothelial cell (EC) sensing of fluid shear stress direction is a critical determinant of vascular health and disease. Unidirectional flow induces EC alignment and vascular homeostasis, whereas bidirectional flow has pathophysiological effects. ECs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c40a15923aad2414c3a6f8ec3bc7208a
https://doi.org/10.1242/jcs.229542

Reticular adhesions: A new class of adhesion complex that mediates cell-matrix attachment during mitosis

Autor: Xiaowei Gong, Matthew Jones, Martin J. Humphries, Anna Oddone, Melike Lakadamyali, Staffan Strömblad, Helene Olofsson, Janet A. Askari, Sara A. Göransson, John G. Lock

Adhesion to the extracellular matrix (ECM) persists during mitosis in most cell types. Yet, classical adhesion complexes (ACs), such as focal adhesions and focal complexes, do and must disassemble to enable cytoskeletal rearrangements associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7d41b71e29706f43568725ad439933