Zobrazeno 1 - 10
of 405
pro vyhledávání: '"Janet, M Lord"'
Autor:
Ayushman Gupta, Rosemary Nicholas, Jordan J. McGing, Aline V. Nixon, Joanne E. Mallinson, Tricia M. McKeever, Christopher R. Bradley, Mathew Piasecki, Eleanor F. Cox, James Bonnington, Janet M. Lord, Christopher E. Brightling, Rachael A. Evans, Ian P. Hall, Susan T. Francis, Paul L. Greenhaff, Charlotte E. Bolton
Publikováno v:
Experimental Physiology, Vol 109, Iss 8, Pp 1274-1291 (2024)
Abstract We evaluated the impacts of COVID‐19 on multi‐organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease w
Externí odkaz:
https://doaj.org/article/831aadef98ae4b05acd56b3245ca5f36
Autor:
Thomas Nicholson, Amritpal Dhaliwal, Jonathan I. Quinlan, Sophie L. Allen, Felicity R. Williams, Jon Hazeldine, Kirsty C. McGee, Jack Sullivan, Leigh Breen, Ahmed M. Elsharkawy, Matthew J. Armstrong, Simon W. Jones, Carolyn A. Greig, Janet M. Lord
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 7, Pp 1667-1681 (2024)
Abstract Patients with chronic liver disease (CLD) often present with significant frailty, sarcopenia, and impaired immune function. However, the mechanisms driving the development of these age-related phenotypes are not fully understood. To determin
Externí odkaz:
https://doaj.org/article/0915fd3c614042489026aea03cbe9dbe
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundThe mechanisms underlying the state of systemic immune suppression that develops following major trauma are poorly understood. A post-injury increase in circulating levels of prostaglandin E2 (PGE2) has been proposed as a contributory facto
Externí odkaz:
https://doaj.org/article/9ca8aecbb41547c3b68a7bb376de5af8
Autor:
David G Wilson, Janet M Lord, John M Morgan, Paul R Roberts, Archana Sharma-Oates, James Sheldon, Daniel F Power
Publikováno v:
Open Heart, Vol 11, Iss 2 (2024)
Objective Most patients who have an implantable cardioverter-defibrillator (ICD) implant do not receive life-prolonging therapy from it. Little research has been undertaken to determine which patients benefit the least from ICD therapy. As patients a
Externí odkaz:
https://doaj.org/article/ec98abc3815047379cb763a5a2a2b0ca
Autor:
Olivia C. Leavy, Richard J. Russell, Ewen M. Harrison, Nazir I. Lone, Steven Kerr, Annemarie B. Docherty, Aziz Sheikh, Matthew Richardson, Omer Elneima, Neil J. Greening, Victoria Claire Harris, Linzy Houchen-Wolloff, Hamish J.C. McAuley, Ruth M. Saunders, Marco Sereno, Aarti Shikotra, Amisha Singapuri, Raminder Aul, Paul Beirne, Charlotte E. Bolton, Jeremy S. Brown, Gourab Choudhury, Nawar Diar Bakerly, Nicholas Easom, Carlos Echevarria, Jonathan Fuld, Nick Hart, John R. Hurst, Mark Jones, Dhruv Parekh, Paul Pfeffer, Najib M. Rahman, Sarah Rowland-Jones, Ajay M. Shah, Dan G. Wootton, Caroline Jolley, A.A. Roger Thompson, Trudie Chalder, Melanie J. Davies, Anthony De Soyza, John R. Geddes, William Greenhalf, Simon Heller, Luke Howard, Joseph Jacob, R. Gisli Jenkins, Janet M. Lord, Will D-C. Man, Gerry P. McCann, Stefan Neubauer, Peter J.M. Openshaw, Joanna Porter, Matthew J. Rowland, Janet T. Scott, Malcolm G. Semple, Sally J. Singh, David Thomas, Mark Toshner, Keir Lewis, Liam G. Heaney, Andrew Briggs, Bang Zheng, Mathew Thorpe, Jennifer K. Quint, James D. Chalmers, Ling-Pei Ho, Alex Horsley, Michael Marks, Krisnah Poinasamy, Betty Raman, Louise V. Wain, Christopher E. Brightling, Rachael A. Evans
Publikováno v:
ERJ Open Research, Vol 10, Iss 5 (2024)
Background In patients with coronavirus disease 2019 (COVID-19) requiring supplemental oxygen, dexamethasone reduces acute severity and improves survival, but longer-term effects are unknown. We hypothesised that systemic corticosteroid administratio
Externí odkaz:
https://doaj.org/article/1d2fc6dbfe284fe4960b0e7810b277e4
Autor:
Sebastian Tullie, Thomas Nicholson, Jonathan R. B. Bishop, Kirsty C. McGee, Ali Asiri, Jack Sullivan, Yung-Yi Chen, Amanda V. Sardeli, Antonio Belli, Paul Harrison, Naiem S. Moiemen, Janet M. Lord, Jon Hazeldine
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundTraumatic and thermal injuries result in a state of systemic immune suppression, yet the mechanisms that underlie its development are poorly understood. Released from injured muscle and lysed red blood cells, heme is a damage associated mol
Externí odkaz:
https://doaj.org/article/0f2a83c51ecb4881b73ffe4b992c1805
Autor:
Aidan Anderson, Nada Alfahad, Dulani Wimalachandra, Kaouthar Bouzinab, Paula Rudzinska, Heather Wood, Isabel Fazey, Heping Xu, Timothy J. Lyons, Nicholas M. Barnes, Parth Narendran, Janet M. Lord, Saaeha Rauz, Ian G. Ganley, Tim M. Curtis, Graham R. Wallace, Jose R. Hombrebueno
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract The recovery of mitochondrial quality control (MQC) may bring innovative solutions for neuroprotection, while imposing a significant challenge given the need of holistic approaches to restore mitochondrial dynamics (fusion/fission) and turno
Externí odkaz:
https://doaj.org/article/49bb462680fd472a9c0826d8dc86da53
Autor:
Janet M. Lord, Tonny Veenith, Jack Sullivan, Archana Sharma-Oates, Alex G. Richter, Neil J. Greening, Hamish J. C. McAuley, Rachael A. Evans, Paul Moss, Shona C. Moore, Lance Turtle, Nandan Gautam, Ahmed Gilani, Manan Bajaj, Louise V. Wain, Christopher Brightling, Betty Raman, Michael Marks, Amisha Singapuri, Omer Elneima, Peter J. M. Openshaw, Niharika A. Duggal, on behalf of the PHOSP-COVID Study collaborative group, ISARIC4C investigators
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-18 (2024)
Abstract Background The striking increase in COVID-19 severity in older adults provides a clear example of immunesenescence, the age-related remodelling of the immune system. To better characterise the association between convalescent immunesenescenc
Externí odkaz:
https://doaj.org/article/561f02bce68f4540ad8f7537241b5e00
Publikováno v:
Experimental Gerontology, Vol 187, Iss , Pp 112365- (2024)
Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the f
Externí odkaz:
https://doaj.org/article/38ae506214534199ae6b8110fb11c403
Autor:
Clare E. West, Mohd Karim, Maria J. Falaguera, Leo Speidel, Charlotte J. Green, Lisa Logie, Jeremy Schwartzentruber, David Ochoa, Janet M. Lord, Michael A. J. Ferguson, Chas Bountra, Graeme F. Wilkinson, Beverley Vaughan, Andrew R. Leach, Ian Dunham, Brian D. Marsden
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Advancing age is the greatest risk factor for developing multiple age-related diseases. Therapeutic approaches targeting the underlying pathways of ageing, rather than individual diseases, may be an effective way to treat and prevent age-rel
Externí odkaz:
https://doaj.org/article/bd0a4e946edc4e929857d3968138af9c