Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Janet, Liptrot"'
Autor:
Pradeep J. Nathan, S. Babli Millais, Alex Godwood, Odile Dewit, David M. Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T. Maruff, Gregory A. Light, Alastair J.H. Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild‐to‐moderate Alzheimer's disease (AD) on background donepezil 10 mg/day. M
Externí odkaz:
https://doaj.org/article/d2ea8035b82442a48e018eec2348acbe
Autor:
Pradeep J, Nathan, S Babli, Millais, Alex, Godwood, Odile, Dewit, David M, Cross, Janet, Liptrot, Bharat, Ruparelia, Stephen Paul, Jones, Geor, Bakker, Paul T, Maruff, Gregory A, Light, Alastair J H, Brown, Malcolm Peter, Weir, Miles, Congreve, Tim, Tasker
Publikováno v:
Alzheimer'sdementia (New York, N. Y.). 8(1)
This study examined the safety and pharmacodynamic effects of selective muscarinic MA randomized, double-blind, placebo-controlled 4-week safety study of HTL0018318 with up-titration and maintenance phases, observing exploratory effects on electrophy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ad0c05b300f87c734f6afd7887305f6d
https://pubmed.ncbi.nlm.nih.gov/35229025
https://pubmed.ncbi.nlm.nih.gov/35229025
Publikováno v:
Journal of neurochemistry. 61(6)
1, 2, 3, 4-Tetrahydro-2-methyl-4, 6, 7-isoquinolinetriol (TMIQ) was synthesised and tested for activity as a dopamine-depleting agent in rat brain. After intracerebroventricular infusion, TMIQ caused reductions in dopamine concentrations in substanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78c32361be1983b1f5d8064105132ab
https://pubmed.ncbi.nlm.nih.gov/7504086
https://pubmed.ncbi.nlm.nih.gov/7504086