Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Janelle Y. Saulter"'
Autor:
Oliver T. Parkinson, Mary F. Paine, James L. Allen, Janelle Y. Saulter, Michael Hall, David W. Boykin, James Edwin Hall, Greg J. Loewen, Richard R. Tidwell, Chad E. Stephens, Etsuko Usuki, Darryl C. Zeldin, Yen Ling Cheung, Arlene S. Bridges, Andrew Parkinson, Michael Zhuo Wang
Publikováno v:
Drug Metabolism and Disposition. 34:1985-1994
DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime] is biotransformed to the potent antiparasitic diamidine DB75 [2,5-bis(4-amidinophenyl) furan] by sequential oxidative O-demethylation and reductive N-dehydroxylation reactions. Previous work
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd79286dadf2572a54ca93760fabd03
https://doi.org/10.1124/dmd.106.010587
https://doi.org/10.1124/dmd.106.010587
Autor:
Arlene S. Bridges, Qiyue Hu, Reto Brun, Richard R. Tidwell, Mariappan Anbazhagan, Farial A. Tanious, Amanda Mathis, W. David Wilson, Tanja Wenzler, David W. Boykin, Iris Francesconi, James Edwin Hall, Mohamed A. Ismail, Arvind Kumar, Janelle Y. Saulter
Publikováno v:
Antimicrobial agents and chemotherapy. 51(8)
Human African trypanosomiasis is a devastating disease with only a few treatment options, including pentamidine. Diamidine compounds such as pentamidine, DB75, and DB820 are potent antitrypanosomal compounds. Previous investigations have shown that d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27eba58e2ae6ce1e8a19d0522a88772
https://pubmed.ncbi.nlm.nih.gov/17517831
https://pubmed.ncbi.nlm.nih.gov/17517831
Autor:
Janelle Y. Saulter, Richard R. Tidwell, Lauren A. Trepanier, David W. Boykin, James Edwin Hall, Arlene S. Bridges, Mariappan Anbazhagan, Chad E. Stephens, Joseph R. Kurian
Publikováno v:
Drug Metabolism and Disposition.
Furamidine is an effective antimicrobial agent; however, oral potency of furamidine is poor. A prodrug of furamidine, 2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime (DB289), has greatly improved oral potency. DB289 is transformed to furamidine v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501fe5774b0169537fa59df85ac330bc
https://doi.org/10.1124/dmd.105.005017
https://doi.org/10.1124/dmd.105.005017
Publikováno v:
HETEROCYCLES. 60:1133
The synthesis of three metabolites of the prodrug 2,5-bis (4-O-methoxyamidinophenyl)furan (1), 2-(4-hydroxyamidinophenyL)-5-(4-methoxyamidinophenyl)furan (M1) 2-(4-amidinophenyl)-5-(4-ethoxyamidinophenyl)-furan (M3) and 2-(4-amidinophenyl)- 5-(4-hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d428ea77e21ebdc031d7f25e2411a2ac
https://doi.org/10.3987/com-03-9716
https://doi.org/10.3987/com-03-9716