Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Janelle Simon"'
Autor:
Loretah Chibaya, Katherine C. Murphy, Kelly D. DeMarco, Sneha Gopalan, Haibo Liu, Chaitanya N. Parikh, Yvette Lopez-Diaz, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Sachliv K. Chana, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti
Publikováno v:
Nature Cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffe23f36f90beea6a89adaad58258efa
https://doi.org/10.1038/s43018-023-00553-8
https://doi.org/10.1038/s43018-023-00553-8
Autor:
Kaloyan M. Tsanov, Francisco M. Barriga, Yu-Jui Ho, Direna Alonso-Curbelo, Geulah Livshits, Richard Koche, Timour Baslan, Alexandra N. Wuest, Janelle Simon, Sha Tian, Wei Luan, Scott W. Lowe
Publikováno v:
Cancer Research. 83:3512-3512
Primary and metastatic tumors typically share the same driver gene mutations, but it is unclear if these mutations are functionally relevant across different anatomical sites. Among such mutations, inactivation of the tumor suppressor gene SMAD4 is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f69a7fce6003c774462b1c2a48e8b3a
https://doi.org/10.1158/1538-7445.am2023-3512
https://doi.org/10.1158/1538-7445.am2023-3512
Autor:
Francisco M. Barriga, Kaloyan M. Tsanov, Yu-Jui Ho, Noor Sohail, Amy Zhang, Timour Baslan, Alexandra N. Wuest, Isabella Del Priore, Brigita Meškauskaitė, Geulah Livshits, Direna Alonso-Curbelo, Janelle Simon, Almudena Chaves-Perez, Dafna Bar-Sagi, Christine A. Iacobuzio-Donahue, Faiyaz Notta, Ronan Chaligne, Roshan Sharma, Dana Pe’er, Scott W. Lowe
SUMMARYSomatic chromosomal deletions are prevalent in cancer, yet their functional contributions remain ill-defined. Among the most prominent of these events are deletions of chromosome 9p21.3, which disable a cell intrinsic barrier to tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65471d3e9dc1493fbddcc7afc339ba67
https://doi.org/10.1101/2022.08.22.504793
https://doi.org/10.1101/2022.08.22.504793
Autor:
Francisco M. Barriga, Kaloyan M. Tsanov, Yu-Jui Ho, Noor Sohail, Amy Zhang, Timour Baslan, Alexandra N. Wuest, Isabella Del Priore, Brigita Meškauskaitė, Geulah Livshits, Direna Alonso-Curbelo, Janelle Simon, Almudena Chaves-Perez, Dafna Bar-Sagi, Christine A. Iacobuzio-Donahue, Faiyaz Notta, Ronan Chaligne, Roshan Sharma, Dana Pe’er, Scott W. Lowe
Publikováno v:
Nature cancer. 3(11)
The most prominent homozygous deletions in cancer affect chromosome 9p21.3 and eliminate CDKN2A/B tumor suppressors, disabling a cell-intrinsic barrier to tumorigenesis. Half of 9p21.3 deletions, however, also encompass a type I interferon (IFN) gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef60fba68994d4eb808a30b2ad2d15fe
https://pubmed.ncbi.nlm.nih.gov/36344707
https://pubmed.ncbi.nlm.nih.gov/36344707
Autor:
Loretah Chibaya, Katherine C. Murphy, Yvette Lopez-Diaz, Kelly D. DeMarco, Haibo Liu, Sneha Gopalan, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti
T cell-activating immunotherapies that produce durable and even curative responses in some malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor tumor immunogenicity. We and others have demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570739343b1e0e49ab96836332f5e641
https://doi.org/10.1101/2022.06.21.495523
https://doi.org/10.1101/2022.06.21.495523
Autor:
Josef Leibold, Corina Amor, Kaloyan M. Tsanov, Yu-Jui Ho, Francisco J. Sánchez-Rivera, Judith Feucht, Timour Baslan, Hsuan-An Chen, Sha Tian, Janelle Simon, Alexandra Wuest, John E. Wilkinson, Scott W. Lowe
Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of this disease are poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf02d9911027615b5a32dcd4a923f745
https://doi.org/10.1101/2022.06.15.494941
https://doi.org/10.1101/2022.06.15.494941
Autor:
Janelle Simon, Elisa de Stanchina, Lihua Julie Zhu, Haibo Liu, Scott W. Lowe, John P. Morris, Yvette Lopez-Diaz, Loretah Chibaya, Katherine C. Murphy, Marcus Ruscetti, Lakhena Leang, Wei Luan, Amanda Kulick, Yu-Jui Ho
Publikováno v:
Cancer Research. 81:PO-124
T cell-targeting immunotherapies that produce durable and sometimes curative responses in other malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to poor T cell infiltration and tumor immunogenicity. We and others have demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c7042b8e977aed7d09f5f30c3e635df
https://doi.org/10.1158/1538-7445.panca21-po-124
https://doi.org/10.1158/1538-7445.panca21-po-124
Autor:
Scott W. Lowe, Elisa de Stanchina, Josef Leibold, Ramya Sridharan, John E. Wilkinson, Robert J. Norgard, Daniel A. Heller, Myles Fennell, John P. Morris, Paul B. Romesser, James A. Russell, Jinyang Li, Ben Z. Stanger, Charles J. Sherr, Riccardo Mezzadra, Amanda Kulick, Janelle Simon, Direna Alonso-Curbelo, Yu-Jui Ho, Marcus Ruscetti
Publikováno v:
Cell
Summary KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity, immunosuppression, and resistance to chemo- and immunotherapies. We show that a combination of MEK and CDK4/6 inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d6685e65c0fdc86be5f8a16289599f
https://pubmed.ncbi.nlm.nih.gov/34478658
https://pubmed.ncbi.nlm.nih.gov/34478658
Autor:
Josef Leibold, Daniel A. Heller, Jinyang Li, Charles J. Sherr, Ben Z. Stanger, Myles Fennell, Riccardo Mezzadra, Xiang Li, Yu-Jui Ho, Marcus Ruscetti, John P. Morris, Elisa de Stanchina, Robert J. Norgard, Scott W. Lowe, Ramya Sridharan, John E. Wilkinson, Direna Alonso-Curbelo, Janelle Simon, Paul B. Romesser, James A. Russell, Amanda Kulick
Publikováno v:
Cancer Research. 79:PR01-PR01
Background: KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic response that promotes hypovascularity, poor drug delivery, immunosuppression, and de novo resistance to chemo- and immunotherapies. Recently, we demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64a582780ba1fb5e9a2f54cbef9bdd9c
https://doi.org/10.1158/1538-7445.panca19-pr01
https://doi.org/10.1158/1538-7445.panca19-pr01
Autor:
Johan H. van Es, Scott W. Lowe, Lukas E. Dow, Janelle Simon, Kevin P. O’Rourke, Darjus F. Tschaharganeh, Hans Clevers
Publikováno v:
Cell, 161(7), 1539-52. Elsevier B.V.
Cell, 161(7), 1539. Cell Press
Cell, 161(7), 1539. Cell Press
SummaryThe adenomatous polyposis coli (APC) tumor suppressor is mutated in the vast majority of human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine whether Apc disruption is required for tumor maintenance, we developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c16e7807a3d621be903c8086c3c8a1
https://doi.org/10.1016/j.cell.2015.05.033
https://doi.org/10.1016/j.cell.2015.05.033