Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Janelle L. Weaver"'
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Akademický článek
Ion Channel Profile of TRPM8 Cold Receptors Reveals a Role of TASK-3 Potassium Channels in Thermosensation
Autor: Cruz Morenilla-Palao, Enoch Luis, Carlos Fernández-Peña, Eva Quintero, Janelle L. Weaver, Douglas A. Bayliss, Félix Viana
Publikováno v: Cell Reports, Vol 8, Iss 5, Pp 1571-1582 (2014)
Animals sense cold ambient temperatures through the activation of peripheral thermoreceptors that express TRPM8, a cold- and menthol-activated ion channel. These receptors can discriminate a very wide range of temperatures from innocuous to noxious.
Externí odkaz: https://doaj.org/article/ca7d43b6c075413ea13af2ff9360b359
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2
Nalcn Is a 'Leak' Sodium Channel That Regulates Excitability of Brainstem Chemosensory Neurons and Breathing
Autor: Josh Sen, Janelle L. Weaver, Yingtang Shi, Chikara Abe, Shaofang Shu, Ruth L. Stornetta, Benjamin B. Holloway, Edward Perez-Reyes, Natasha N. Kumar, Patrice G. Guyenet, Douglas A. Bayliss
Publikováno v: Journal of Neuroscience. 36:8174-8187
The activity of background potassium and sodium channels determines neuronal excitability, but physiological roles for “leak” Na+ channels in specific mammalian neurons have not been established. Here, we show that a leak Na+ channel, Nalcn, is e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66aa9ba717575535b3252f1879d9ee1
https://doi.org/10.1523/jneurosci.1096-16.2016
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3
Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons
Autor: Yingtang Shi, Roman M. Lazarenko, Douglas A. Bayliss, Jorge Soliz, Ana Velic, Patrice G. Guyenet, Janelle L. Weaver, Max Gassmann, Klaus Seuwen, Nilufar Mohebbi, Carsten A. Wagner, Edward Perez-Reyes, Thomas Suply, Natasha N. Kumar, Josh Sen, Marie-Gabrielle Ludwig, Stephen B. G. Abbott, Sheng Wang, Carla Bettoni, Ke-Yong Li
Publikováno v: SCIENCE
Receptor in the brain controls breathing Control of breathing in mammals depends primarily not on sensing oxygen, but rather on detecting concentrations of carbon dioxide in the blood. Failure of this system can cause potentially deadly sleep apnias.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64396b646d733769a567e2cf0a4f28a5
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4
Hematopoietic pannexin 1 function is critical for neuropathic pain
Autor: Julia K. Krupa, Gregory W. Brown, Michael S. Schappe, Suresh K. Mendu, Monica W. Buckley, Yu-Hsin Chiu, Vesna Jevtovic-Todorovic, Janelle L. Weaver, Jin K Kim, Shaofang Shu, Joyce Chung, Kodi S. Ravichandran, Sanja Arandjelovic, Bimal N. Desai, Douglas A. Bayliss
Publikováno v: Scientific Reports
Neuropathic pain symptoms respond poorly to available therapeutics, with most treated patients reporting unrelieved pain and significant impairment in daily life. Here, we show that Pannexin 1 (Panx1) in hematopoietic cells is required for pain-like
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab13ca4dfc20969568f8df0b47a3d9c2
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5
S-Nitrosylation Inhibits Pannexin 1 Channel Function
Autor: Marie Billaud, Alexander W. Lohman, Joanna K. Sandilos, Adam C. Straub, Silvia Penuela, Norbert Leitinger, Janelle L. Weaver, Dale W. Laird, Douglas A. Bayliss, Brant E. Isakson, Rachael Griffiths
Publikováno v: Journal of Biological Chemistry. 287:39602-39612
S-nitrosylation is a post-translational modification on cysteine(s) that can regulate protein function, and pannexin 1 (Panx1) channels are present in the vasculature, a tissue rich in nitric oxide (NO) species. Therefore, we investigated whether Pan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36fa3b3e376a22997166cbad5a8872d6
https://doi.org/10.1074/jbc.m112.397976
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6
Molecular Metabolism
Autor: Joseph A. Calderone, Amandeep Bajwa, Douglas A. Bayliss, Jeffrey W. Holmes, Webster L. Santos, Zhen Yan, Kyle L. Hoehn, George W. Rogers, Frances L. Byrne, Kohki Okabe, Mark D. Okusa, Ivan K. H. Poon, Seiichi Uchiyama, Brandon M. Kenwood, Jeffrey J. Saucerman, Liping Huang, Janelle L. Weaver, Ryan H. Lo, Kevin R. Lynch, Jose L. Tomsig, Ajit S. Divakaruni, Linda Columbus, Beverley A. Murrow, G. Cameron Coleman, Kodi S. Ravichandran, Jeffrey S. Smith
Publikováno v: Molecular metabolism, vol 3, iss 2
Dysregulation of oxidative phosphorylation is associated with increased mitochondrial reactive oxygen species production and some of the most prevalent human diseases including obesity, cancer, diabetes, neurodegeneration, and heart disease. Chemical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1036713c551805c567f26a3908f8a8d0
https://escholarship.org/uc/item/2vz9776k
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7
Ion channel profile of TRPM8 cold receptors reveals a role of TASK-3 potassium channels in thermosensation
Autor: Félix Viana, Enoch Luis, Eva Quintero, Carlos Fernández-Peña, Douglas A. Bayliss, Janelle L. Weaver, Cruz Morenilla-Palao
Publikováno v: Cell Reports, Vol 8, Iss 5, Pp 1571-1582 (2014)
Animals sense cold ambient temperatures through the activation of peripheral thermoreceptors that express TRPM8, a cold- and menthol-activated ion channel. These receptors can discriminate a very wide range of temperatures from innocuous to noxious.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b27192380e2977f6f3382d587b1b9f
http://hdl.handle.net/10261/308863
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