Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Janelle E. Collinge"'
Autor:
Ian Smyth, Douglas F. Hacking, Adrienne A. Hilton, Nigora Mukhamedova, Peter J. Meikle, Sarah Ellis, Keith Slatterley, Janelle E. Collinge, Carolyn A. de Graaf, Melanie Bahlo, Dmitri Sviridov, Benjamin T. Kile, Douglas J. Hilton
Publikováno v:
PLoS Genetics, Vol 4, Iss 10 (2008)
Externí odkaz:
https://doaj.org/article/0c80f7fce62f438f8c1982f948b7663a
Autor:
Cody C. Allison, Benjamin T. Kile, Esme C. Hatchell, Maria Kozlovskaia, Catriona McLean, Pradnya Gangatirkar, Gabriela Brumatti, Marc Pellegrini, Pamela A. McCombe, Julie Sheridan, Donald Metcalf, Klaus Warnatz, Natasha Silke, Maria C. Tanzer, Janelle E. Collinge, Seth L. Masters, Victoria E. Jackson, Jason Corbin, David B. Ascher, Dina Stockwell, Nicole Vlahovich, Zhixiu Li, James M. Murphy, Carola G. Vinuesa, Maria Kauppi, Ronald M. Laxer, John Reveille, Adrienne A. Hilton, John Silke, Ian J. Majewski, David Hughes, Gillian M. Tannahill, Melanie Bahlo, Christine Biben, Michael A. Silk, Maria A. Fiatarone Singh, Cathrine Hall, Peter E. Czabotar, Jian-Guo Zhang, Polly J. Ferguson, Sukhdeep K Spall, Carolyn A. de Graaf, Michael D. Stutz, Nils Venhoff, Alexander G. Bassuk, Zikou Liu, Holly Anderton, Michael S. Hildebrand, Tracy A. Willson, James A Rickard, Hiroyasu Nakano, Vicki Athanasopoulos, Matthew A. Brown, Samuel N. Young, Jens Thiel, Emma J. Petrie, Diep Chau, Sarah E Garnish, Sanae Miyake, Anne Tripaydonis, Warren S. Alexander, Allison Cox, Stefan Blum, Joanne M Hildebrand, Thomas S. Scerri, Kristin A Rigbye, Leila N. Varghese, Benjamin W. Darbro, Emma C. Josefsson, Ladina Di Rago
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, MlklD139V, that alters the two-helix ‘brace’ that connects the killer four-helix bundle and reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead403f9f5ff09d2fd122f72a19f707f
http://link.springer.com/article/10.1038/s41467-020-16819-z
http://link.springer.com/article/10.1038/s41467-020-16819-z
Autor:
Ian Smyth, Douglas F Hacking, Adrienne A Hilton, Nigora Mukhamedova, Peter J Meikle, Sarah Ellis, Keith Satterley, Janelle E Collinge, Carolyn A de Graaf, Melanie Bahlo, Dmitri Sviridov, Benjamin T Kile, Douglas J Hilton
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000192 (2008)
Harlequin Ichthyosis (HI) is a severe and often lethal hyperkeratotic skin disease caused by mutations in the ABCA12 transport protein. In keratinocytes, ABCA12 is thought to regulate the transfer of lipids into small intracellular trafficking vesicl
Externí odkaz:
https://doaj.org/article/4faa357e23a945698478d05e5d09503a
Autor:
Cody C. Allison, Pradnya Gangatirkar, Natasha Silke, Maria A. Fiatarone Singh, Alexander G. Bassuk, Joanne M Hildebrand, Julie Sheridan, Janelle E. Collinge, Matthew A. Brown, Nicole Vlahovich, Melanie Bahlo, Warren S. Alexander, Peter A. Czabotar, Thomas S. Scerri, Zikou Liu, Michael S. Hildebrand, James M. Murphy, Sukhdeep K Spall, Ronald M. Laxer, Cathrine Hall, Holly Anderton, Esme C. Hatchell, Maria Kozlovskaia, Adrienne A. Hilton, Maria C. Tanzer, Emma J. Petrie, Hiroyasu Nakano, Vicki Athanasopoulos, Klaus Warnatz, Michael A. Silk, Jens Thiel, James A Rickard, Pamela A. McCombe, John Reveille, Tracy A. Willson, Emma C. Josefsson, Gillian M. Tannahill, Stefan Blum, Jason Corbin, Zhixiu Li, Nils Venhoff, Catriona McLean, Sarah E Garnish, Dina Stockwell, Sanae Miyake, Anne Tripaydonis, Polly J. Ferguson, Allison Cox, John Silke, David Hughes, Jian-Guo Zhang, Michael D. Stutz, Samuel N. Young, Carolyn A. de Graaf, Marc Pellegrini, Diep Chau, Donald Metcalf, Ian J. Majewski, Carola G. Vinuesa, David B. Ascher, Maria Kauppi, Seth L. Masters, Ben T. Kile, Kristin A Rigbye, Benjamin W. Darbro
SUMMARYWe have isolated a mouse strain with a single missense mutation in the gene encoding MLKL, the essential effector of necroptotic cell death. The resulting substitution lies within the two-helix ‘brace’ and confers constitutive, RIPK3 indep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a37a517e02a47fb22c931fa0867867
Autor:
Gerhard Rank, Stephen M. Jane, Fiona C. Brown, Nick Scott, David J. Curtis, Nadia C Whitelaw, Janelle E. Collinge, Jim Vadolas, Benjamin T. Kile, Emma Whitelaw, Nicola Vickaryous
Publikováno v:
Blood Cells, Molecules, and Diseases. 50:86-92
Forward genetic screens have been performed in many species to identify phenotypes in specific organ systems. We have undertaken a large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis screen to identify dominant mutations that perturb erythropoiesis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49682737a7c3b8f4de5a5ddead0ac6da
https://doi.org/10.1016/j.bcmd.2012.09.004
https://doi.org/10.1016/j.bcmd.2012.09.004
Autor:
Janelle E. Collinge, Adrienne A. Hilton, Benjamin T. Kile, Donald Metcalf, Maria Kauppi, Douglas J. Hilton, Warren S. Alexander, Ashley P. Ng, Craig D. Hyland
Publikováno v:
Proceedings of the National Academy of Sciences. 109:576-581
Diverse mutations in the genes encoding hemoglobin (Hb) have been characterized in human disease. We describe here a mutation in the mouse Hbb-b2 gene, denoted Plt12 , that precisely mimics the human hemoglobin Hotel Dieu variant. The mutation result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bfd9956e977936593d9cfd45e262d4
https://doi.org/10.1073/pnas.1119146109
https://doi.org/10.1073/pnas.1119146109
Autor:
Warren S. Alexander, Robyn Starr, Anne M Verhagen, Janelle E. Collinge, Hayley A Croom, Morgan E. Wallace, Mhairi J Maxwell, Donald Metcalf, Douglas J. Hilton, Ankita Goradia, Margaret L. Hibbs, Benjamin T. Kile, Sarah Jones
Publikováno v:
The Journal of Immunology. 182:2020-2029
Lyn kinase, a member of the Src family of tyrosine kinases, functions as both a positive and negative regulator of B cell activation. In the absence of Lyn, BCR signaling is unregulated, leading to perturbed B cell development, hyperactive B cells, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbb8f445f32e02efa153be52a37a4a9
https://doi.org/10.4049/jimmunol.0803127
https://doi.org/10.4049/jimmunol.0803127
Autor:
Donald Metcalf, Kylie D. Mason, Priscilla N. Kelly, Adrienne A. Hilton, Andrew W. Roberts, Sarah Ellis, Janelle E. Collinge, David C.S. Huang, Benjamin T. Kile, Marina R. Carpinelli, Paul G Ekert, Jamie I. Fletcher
Publikováno v:
Cell. 128(6):1173-1186
Platelets are anuclear cytoplasmic fragments essential for blood clotting and wound healing. Despite much speculation, the factors determining their life span in the circulation are unknown. We show here that an intrinsic program for apoptosis contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052d88162659fd554c0347312a5b7ea5
Autor:
Ashlee J. Conway, Fiona C. Brown, Stephen M. Jane, David J. Curtis, James S. Wiley, Ben T. Kile, Janelle E. Collinge, Catriona McLean, Loretta Cerruti
Publikováno v:
Blood. 126(26)
We used an N-ethyl-N-nitrosurea-based forward genetic screen in mice to identify new genes and alleles that regulate erythropoiesis. Here, we describe a mouse line expressing an activated form of the K-Cl cotransporter Slc12a4 (Kcc1), which results i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79b062d8c62bd3e457389cfd322ef35
https://pubmed.ncbi.nlm.nih.gov/26705342
https://pubmed.ncbi.nlm.nih.gov/26705342
Publikováno v:
Thrombosis Research. 122:861-863
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b47094483b1baae3917ebff7cd9cf92c
https://doi.org/10.1016/j.thromres.2008.06.011
https://doi.org/10.1016/j.thromres.2008.06.011