Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Janel K. Warmka"'
Autor:
Kristine S Klos, Janel K Warmka, Disa M Drachenberg, Liang Chang, G W Gant Luxton, Cheuk T Leung, Kathryn L Schwertfeger, Elizabeth V Wattenberg
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90722 (2014)
The potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) alters many cellular processes through activation of its receptor protein kinase C (PKC), including gene expression, cell cycle, and the regulation of cell morphology, raising an im
Externí odkaz:
https://doaj.org/article/4400e2d9b9644eec8129048b2db80e55
Autor:
Charuta C. Palsuledesai, Edgar A. Arriaga, Ling Li, Janel K. Warmka, Yen Chih Wang, Dustin Chernick, Elizabeth V. Wattenberg, Mark D. Distefano, Michelle M. Kuhns, Joshua D. Ochocki
Publikováno v:
ACS Chemical Biology
Protein prenylation is a post-translational modification that is responsible for membrane association and protein–protein interactions. The oncogenic protein Ras, which is prenylated, has been the subject of intense study in the past 20 years as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c0b8dde74ecd9c67eab80fdf4dfcd0
https://doi.org/10.1021/acschembio.6b00421
https://doi.org/10.1021/acschembio.6b00421
Autor:
Janel K. Warmka, Choua C. Vu, Elizabeth V. Wattenberg, Lee C. Brown, Li Li, Lisa A. Peterson, Anthony E. Pegg, Yesha Patel, Meredith E. Cummings, Anna M. Urban, Daniel O. Stram
Publikováno v:
Chemical Research in Toxicology. 26:1464-1473
α-Hydroxynitrosamine metabolites of nitrosamines decompose to a reactive diazohydroxide and an aldehyde. To test the hypothesis that the aldehydes contribute to the harmful effects of nitrosamines, the toxic and mutagenic activities of three model m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b650f3f85b9cb33dfcec73e91193fa9f
https://doi.org/10.1021/tx400196j
https://doi.org/10.1021/tx400196j
Autor:
Chengguo Xing, Eric L. Solberg, Aaron T. Charlson, Elizabeth V. Wattenberg, Balasubramanian Srinivasan, Nicholette A. Zeliadt, Janel K. Warmka
Publikováno v:
Biochemical and biophysical research communications. 424(3)
We are interested in investigating the biological activity of chalcones, a major class of compounds found in the beverage kava, in order to develop potent and selective chemopreventive candidates. Consumption of kava in the South Pacific Islands is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10008a89cab166dfb7f5194f66e3fd8
https://pubmed.ncbi.nlm.nih.gov/22771807
https://pubmed.ncbi.nlm.nih.gov/22771807
Autor:
Nicholette A. Zeliadt, David A. Blank, Joshua D. Ochocki, Elizabeth V. Wattenberg, Timothy M. Dore, Janel K. Warmka, Mark D. Distefano, Daniel Abate-Pella
The creation of caged molecules involves the attachment of protecting groups to biologically active compounds such as ligands, substrates and drugs that can be removed under specific conditions. Photoremovable caging groups are the most common due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f58a51158391d84c37793b60fca594b
https://europepmc.org/articles/PMC3436068/
https://europepmc.org/articles/PMC3436068/
Publikováno v:
The Journal of biological chemistry. 279(32)
We have capitalized on the unique properties of the skin tumor promoter palytoxin, which does not activate protein kinase C, to investigate alternative mechanisms by which major signaling molecules can be modulated during carcinogenesis. We report he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffee2f471b0273dc3b28fc9dcc00489
https://pubmed.ncbi.nlm.nih.gov/15159408
https://pubmed.ncbi.nlm.nih.gov/15159408
Autor:
Laura J. Mauro, Elizabeth V. Wattenberg, Jennifer J. Westendorf, Susanna E. Winston, Rachel A. Kahler, Nicholette A. Zeliadt, Janel K. Warmka
Publikováno v:
Biochemical and biophysical research communications. 317(2)
In mouse epidermis in vivo, the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) increases gene expression of matrix metalloproteinase-13 (MMP-13), an enzyme implicated in carcinogenesis. Here we used a keratinocyte cell line (308) derived f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be752e4e73fd6ce9c67ce071bb9ded8
https://pubmed.ncbi.nlm.nih.gov/15063796
https://pubmed.ncbi.nlm.nih.gov/15063796
Publikováno v:
Toxicology and applied pharmacology. 192(3)
We have been investigating how the novel skin tumor promoter palytoxin transmits signals through mitogen activated protein kinases (MAPKs). Palytoxin activates three major MAPKs, extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c742606b9c73b6ee24603567279db
https://pubmed.ncbi.nlm.nih.gov/14575638
https://pubmed.ncbi.nlm.nih.gov/14575638
Publikováno v:
Toxicology and applied pharmacology. 185(1)
We have been probing the molecular mechanisms of tumor promoters that stimulate distinct initial signals to define critical downstream biochemical events in carcinogenesis. The action of the novel skin tumor promoter palytoxin on signaling and gene e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4e923e7ae3b1297ac33e834203b588
https://pubmed.ncbi.nlm.nih.gov/12460732
https://pubmed.ncbi.nlm.nih.gov/12460732
Autor:
Janel K. Warmka, Elizabeth V. Wattenberg, Disa M. Drachenberg, G. W. Gant Luxton, Cheuk T. Leung, Kathryn L. Schwertfeger, Liang Chang, Kristine S. Klos
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90722 (2014)
PLoS ONE
PLoS ONE
The potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) alters many cellular processes through activation of its receptor protein kinase C (PKC), including gene expression, cell cycle, and the regulation of cell morphology, raising an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9207c625be5dee7a5e1bcf2f4259b84
https://doi.org/10.1371/journal.pone.0090722
https://doi.org/10.1371/journal.pone.0090722