IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation.

Autor: Mullan CW; Department of Immunobiology, Yale School of Medicine, New Haven, CT.; Department of Surgery, Yale School of Medicine, New Haven, CT., Summer L; Department of Immunobiology, Yale School of Medicine, New Haven, CT., Lopez-Giraldez F; Department of Genetics, Yale School of Medicine, New Haven, CT.; Yale Center for Genome Analysis, Yale School of Medicine, West Haven, CT., Tobiasova Z; Department of Immunobiology, Yale School of Medicine, New Haven, CT., Manes TD; Department of Immunobiology, Yale School of Medicine, New Haven, CT., Yasothan S; Department of Immunobiology, Yale School of Medicine, New Haven, CT., Song G; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China., Jane-Wit D; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT.; Department of Cardiology, VA Connecticut Healthcare System, West Haven, CT., Saltzman WM; Department of Biomedical Engineering, Yale University, New Haven, CT.; Department of Chemical & Environmental Engineering, Yale University, New Haven, CT.; Department of Cellular & Molecular Physiology, Yale University, New Haven, CT.; Department of Dermatology, Yale University, New Haven, CT., Pober JS; Department of Immunobiology, Yale School of Medicine, New Haven, CT.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Nov 01; Vol. 213 (9), pp. 1338-1348.

ZFYVE21 promotes endothelial nitric oxide signaling and vascular barrier function in the kidney during aging.

Autor: Jiang Q; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cardiology, West Haven VA Medical Center, West Haven, Connecticut, USA. Electronic address: jiangquan29@gmail.com., Song G; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cardiology, West Haven VA Medical Center, West Haven, Connecticut, USA; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: guiyu.song@yale.edu., He L; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA. Electronic address: liying.he@yale.edu., Li X; Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: xueli19870105@126.com., Jiang B; Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, China. Electronic address: jiangbo@cmu.edu.cn., Wang Q; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cardiology, West Haven VA Medical Center, West Haven, Connecticut, USA., Wang S; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cardiology, West Haven VA Medical Center, West Haven, Connecticut, USA; Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA., Kim C; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut, USA., Barkestani MN; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cardiology, West Haven VA Medical Center, West Haven, Connecticut, USA., Lopez R; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA., Fan M; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA., Wanniarachchi K; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; University of Cambridge, School of Clinical Medicine, Cambridge, UK., Quaranta M; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA., Tian X; Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Mani A; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA., Gonzalez A; Department of Biomedical Engineering, Yale University School of Medicine, New Haven, Connecticut, USA., Goodwin JE; Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA., Sessa WC; Internal Medicine Research Unit, Pfizer, Cambridge, Massachussetts, USA., Ishibe S; Section of Nephrology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA., Jane-Wit D; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA; Department of Cardiology, West Haven VA Medical Center, West Haven, Connecticut, USA. Electronic address: dan.jane-wit@yale.edu.

Publikováno v: Kidney international [Kidney Int] 2024 Sep; Vol. 106 (3), pp. 419-432. Date of Electronic Publication: 2024 May 24.

Complement Membrane Attack Complexes Disrupt Proteostasis to Function as Intracellular Alarmins.

Autor: Jane-Wit D; Yale University., Song G; Yale School of Medicine., He L; Yale University., Jiang Q; Yale University., Barkestani M; Yale University., Wang S; Yale University., Wang Q; Yale University., Ren P; Yale University School of Medicine., Fan M; Yale University School of Medicine., Johnson J; Yale University School of Medicine., Mullan C; Yale School of Medicine.

Publikováno v: Research square [Res Sq] 2024 Jun 19. Date of Electronic Publication: 2024 Jun 19.

Author Correction: A ZFYVE21-Rubicon-RNF34 signaling complex promotes endosome-associated inflammasome activity in endothelial cells.

Autor: Li X; VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA.; Department of Nephrology, Shengjing Hospital of China Medical University, Shenyang, China., Jiang Q; VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA., Song G; VA Connecticut Healthcare System, West Haven, CT, USA. guiyu.song@yale.edu.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA. guiyu.song@yale.edu.; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. guiyu.song@yale.edu., Barkestani MN; VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA., Wang Q; VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA., Wang S; VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA., Fan M; Yale College, Yale University, New Haven, CT, USA., Fang C; VA Connecticut Healthcare System, West Haven, CT, USA.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA., Jiang B; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA.; Dept of Surgery, Yale University School of Medicine, New Haven, CT, USA.; Dept of Vascular Surgery, The First Hospital of China Medical University, Shenyang, China., Johnson J; Dept of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Geirsson A; Dept of Surgery, Yale University School of Medicine, New Haven, CT, USA., Tellides G; Dept of Surgery, Yale University School of Medicine, New Haven, CT, USA., Pober JS; Dept of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Jane-Wit D; VA Connecticut Healthcare System, West Haven, CT, USA. dan.jane-wit@yale.edu.; Department of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA. dan.jane-wit@yale.edu.; Dept of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. dan.jane-wit@yale.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 18; Vol. 14 (1), pp. 8404. Date of Electronic Publication: 2023 Dec 18.

Hedgehog-induced ZFYVE21 promotes chronic vascular inflammation by activating NLRP3 inflammasomes in T cells.

Autor: Jiang B; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA., Wang S; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA.; Division of Cardiology, West Haven VA Medical Center, West Haven, CT 06516, USA., Song G; Division of Cardiology, West Haven VA Medical Center, West Haven, CT 06516, USA.; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China. guiyu.song@yale.edu, Jiang Q; Division of Cardiology, West Haven VA Medical Center, West Haven, CT 06516, USA.; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Fan M; Division of Cardiology, West Haven VA Medical Center, West Haven, CT 06516, USA.; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Fang C; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Li X; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Soh CL; University of Cambridge, School of Clinical Medicine, Hills Rd., Cambridge CB2 0SP, UK., Manes TD; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Cheru N; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Qin L; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA., Ren P; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA., Jortner B; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Wang Q; Division of Cardiology, West Haven VA Medical Center, West Haven, CT 06516, USA.; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Quaranta E; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Yoo P; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA., Geirsson A; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA., Davis RP; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA., Tellides G; Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA., Pober JS; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA., Jane-Wit D; Division of Cardiology, West Haven VA Medical Center, West Haven, CT 06516, USA.; Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. dan.jane-wit@yale.edu

Publikováno v: Science signaling [Sci Signal] 2023 Mar 21; Vol. 16 (777), pp. eabo3406. Date of Electronic Publication: 2023 Mar 21.