Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Jane Y. Edwards"'
Autor:
Amy C. Burke, Brian G. Sutherland, Dawn E. Telford, Marisa R. Morrow, Cynthia G. Sawyez, Jane Y. Edwards, Maria Drangova, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1714-1728 (2018)
Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success in reversing existing obesity
Externí odkaz:
https://doaj.org/article/761ce2d5872b400187ff5a277fcec253
Autor:
Lazar A. Bojic, Dawn E. Telford, Morgan D. Fullerton, Rebecca J. Ford, Brian G. Sutherland, Jane Y. Edwards, Cynthia G. Sawyez, Robert Gros, Bruce E. Kemp, Gregory R. Steinberg, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 7, Pp 1254-1266 (2014)
PPARδ regulates systemic lipid homeostasis and inflammation, but its role in hepatic lipid metabolism remains unclear. Here, we examine whether intervening with a selective PPARδ agonist corrects hepatic steatosis induced by a high-fat, cholesterol
Externí odkaz:
https://doaj.org/article/02e95e718419411d991a2cb2fb2378cb
Autor:
Julia M. Assini, Erin E. Mulvihill, Brian G. Sutherland, Dawn E. Telford, Cynthia G. Sawyez, Sarah L. Felder, Sanjiv Chhoker, Jane Y. Edwards, Robert Gros, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 3, Pp 711-724 (2013)
Obesity-associated chronic inflammation contributes to metabolic dysfunction and propagates atherosclerosis. Recent evidence suggests that increased dietary cholesterol exacerbates inflammation in adipose tissue and liver, contributing to the proathe
Externí odkaz:
https://doaj.org/article/158247674e644e5aa756021704b6e7ce
Autor:
Emma M. Allister, Erin E. Mulvihill, P. Hugh R. Barrett, Jane Y. Edwards, Lindsey P. Carter, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 10, Pp 2218-2229 (2008)
Hepatic overproduction of apolipoprotein B (apoB)-containing lipoproteins is characteristic of the dyslipidemia associated with insulin resistance. Recently, we demonstrated that the flavonoid naringenin, like insulin, decreased apoB secretion from H
Externí odkaz:
https://doaj.org/article/555e4b055d9643f19bdc8707a8ed562f
Autor:
Dawn E. Telford, Brian G. Sutherland, Jane Y. Edwards, Joseph D. Andrews, P. Hugh R. Barrett, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 48, Iss 3, Pp 699-708 (2007)
The combination of ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein (NPC1L1), and an HMG-CoA reductase inhibitor decreases cholesterol absorption and synthesis. In clinical trials, ezetimibe plus simvastatin produces greater LDL-cholesterol
Externí odkaz:
https://doaj.org/article/73153f7bd3b74244833b1ec270c77e66
Autor:
Dawn E. Telford, Jane Y. Edwards, Sara M. Lipson, Brian Sutherland, P.Hugh R. Barrett, John R. Burnett, Elaine S. Krul, Bradley T. Keller, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 5, Pp 943-952 (2003)
Discovery of the ileal apical sodium-dependent bile acid transporter (ASBT) permitted development of specific inhibitors of bile acid reabsorption, potentially a new class of cholesterol-lowering agents. In the present study, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/7c8fb27920264b34957b9666d6ecd11d
Autor:
Nadya M. Morrow, Natasha A. Trzaskalski, Antonio A. Hanson, Evgenia Fadzeyeva, Dawn E. Telford, Sanjiv S. Chhoker, Brian G. Sutherland, Jane Y. Edwards, Murray W. Huff, Erin E. Mulvihill
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42:127-144
Objective: Nobiletin is a dietary flavonoid that improves insulin resistance and atherosclerosis in mice with metabolic dysfunction. Dysregulation of intestinal lipoprotein metabolism contributes to atherogenesis. The objective of the study was to de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d8d86c65e0ba1455c85db28e5307b0b
https://doi.org/10.1161/atvbaha.121.316896
https://doi.org/10.1161/atvbaha.121.316896
Autor:
Brandon Batey, Jane Y. Edwards, Amanda Pfeffer, Tania Haidar, Jason A. Gilliland, Neil Merritt, Alyssa Penney, Douglas D. Fraser, Tanya Charyk Stewart, Andrew F. Clark, Neil Parry
Publikováno v:
Journal of Trauma and Acute Care Surgery. 90:535-543
Background Cell phone use while driving (CPWD) increases the risk of crashing and is a major contributor to injuries and deaths. The objective of this study was to describe the evaluation of a multifaceted, evidence-based population health strategy f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52a991e8dc5490928e611d95de62bb57
https://doi.org/10.1097/ta.0000000000002948
https://doi.org/10.1097/ta.0000000000002948
Autor:
Marisa R. Morrow, Brian G. Sutherland, Jane Y. Edwards, Dawn E. Telford, Amy C. Burke, Maria Drangova, Cynthia G. Sawyez, Murray W. Huff
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 9, Pp 1714-1728 (2018)
Medical Biophysics Publications
Bone and Joint Institute
Medical Biophysics Publications
Bone and Joint Institute
Copyright © 2018 Burke et al. Obesity and its associated metabolic dysfunction and cardiovascular disease risk represent a leading cause of adult morbidity worldwide. Currently available pharmacological therapies for obesity have had limited success
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f221864abbec4ab66bd0eb13e40524dd
http://www.sciencedirect.com/science/article/pii/S0022227520335409
http://www.sciencedirect.com/science/article/pii/S0022227520335409
Autor:
Jane Y. Edwards, J. Geoffrey Pickering, Brian G. Sutherland, Cynthia G. Sawyez, Amy C. Burke, Murray W. Huff, Dawn E. Telford, P. Hugh R. Barrett, Roger S. Newton
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:1178-1190
Objective— Bempedoic acid (BemA; ETC-1002) is a novel drug that targets hepatic ATP-citrate lyase to reduce cholesterol biosynthesis. In phase 2 studies, BemA lowers elevated low-density lipoprotein cholesterol (LDL-C) in hypercholesterolemic patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d464461bfa4ff8f963650f27381fecd7
https://doi.org/10.1161/atvbaha.117.310676
https://doi.org/10.1161/atvbaha.117.310676