Výsledky vyhledávání - "Jane Y. C. Ma"

Crystalline Silica is a Negative Modifier of Pulmonary Cytochrome P-4501A1 Induction

Autor: Ann F. Hubbs, Jane Y. C. Ma, Philip R. Miles, Ricki L. Simoskevitz, Mark Barger, Michael L. Kashon, Mohamed Ghanem, Lori A. Battelli

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 71:521-532

Polycyclic aromatic hydrocarbons (PAHs) are products of incomplete combustion that are commonly inhaled by workers in the dusty trades. Many PAHs are metabolized by cytochrome P-4501A1 (CYP1A1), which may facilitate excretion but may activate pulmona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68f51aed1c7c7325398cb9d2dd1c86b5
https://doi.org/10.1080/15287390801907483

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Apoptosis and Bax Expression are Increased by Coal Dust in the Polycyclic Aromatic Hydrocarbon-Exposed Lung

Autor: Lori A. Battelli, Mohamed Ghanem, Ann F. Hubbs, Joginder Nath, James F. Scabilloni, Michael L. Kashon, Jane Y. C. Ma, Robert R. Mercer

Publikováno v: Environmental Health Perspectives

Coal miners are commonly exposed to coal dust (CD) and polycyclic aromatic hydrocarbons (PAHs). The CD originates within the mine, whereas the PAHs are components of occupational and avocational exposures such as diesel engine exhaust and cigarette s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fe1b3f38467b01a063077bbd05c809a
https://doi.org/10.1289/ehp.8906

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Cooperation of the Inducible Nitric Oxide Synthase and Cytochrome P450 1A1 in Mediating Lung Inflammation and Mutagenicity Induced by Diesel Exhaust Particles

Autor: Hongwen Zhao, Jane Y. C. Ma, Vincent Castranova, Mark Barger, Joseph K. H. Ma

Publikováno v: Environmental Health Perspectives

Diesel exhaust particles (DEPs) have been shown to activate oxidant generation by alveolar macrophages (AMs), alter xenobiotic metabolic pathways, and modify the balance of pro-antiinflammatory cytokines. In this study we investigated the role of nit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3613133006c56c0bd50e5cdbb45350ae
http://europepmc.org/articles/PMC1552032

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Sustained Effect of Inhaled Diesel Exhaust Particles on T-Lymphocyte–Mediated Immune Responses Against Listeria monocytogenes

Autor: James M. Antonini, Mark Barger, Jane Y. C. Ma, Joseph K. H. Ma, Jenny R. Roberts, Caroline C. Dong, Xuejun J. Yin

Publikováno v: Toxicological Sciences. 88:73-81

Studies have shown that exposure to diesel exhaust particles (DEP) suppresses pulmonary host defense against bacterial infection. The present study was carried out to characterize whether DEP exposure exerts a sustained effect in which inhaled DEP in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81922b7eff3818f00b1a92b417d6861e
https://doi.org/10.1093/toxsci/kfi279

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Time Course of Gene Expression of Inflammatory Mediators in Rat Lung after Diesel Exhaust Particle Exposure

Autor: K. Murali Krishna Rao, Terence Meighan, Donna Pack, Mark Barger, Jane Y. C. Ma, Val Vallyathan

Publikováno v: Environmental Health Perspectives

Diesel exhaust particles (DEPs) at three concentrations (5, 35, and 50 mg/kg body weight) were instilled into rats intratracheally. We studied gene expression at 1, 7, and 30 days postexposure in cells obtained by bronchoalveolar lavage (BAL) and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e99db9eac16004df3250e5e531cd10e
https://doi.org/10.1289/ehp.7696

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Suppression of Cell-Mediated Immune Responses to Listeria Infection by Repeated Exposure to Diesel Exhaust Particles in Brown Norway Rats

Autor: Jane Y. C. Ma, James M. Antonini, Charles F. Stanley, Jenny R. Roberts, Caroline C. Dong, Rosana Schafer, Xuejun J. Yin, Joseph K. H. Ma

Publikováno v: Toxicological Sciences. 77:263-271

Diesel exhaust particles (DEP) have been shown to alter pulmonary immune responses to bacterial infection. Exposure of rats to 100 mg/m(3) DEP for 4 h was found to aggravate Listeria monocytogenes(Listeria) infection at 3 days postinfection, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f106409361f05545c031c7eef843666e
https://doi.org/10.1093/toxsci/kfh035

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Inhalation exposure of rats to asphalt fumes generated at paving temperatures alters pulmonary xenobiotic metabolism pathways without lung injury

Autor: Jane Y. C. Ma, D. G. Frazer, Vince Castranova, Ann F. Hubbs, Mark Barger, Apavoo Rengasamy, Seith Tomblyn, Samuel Stone, Lori A. Battelli

Publikováno v: Environmental Health Perspectives

Asphalt fumes are complex mixtures of various organic compounds, including polycyclic aromatic hydrocarbons (PAHs). PAHs require bioactivation by the cytochrome P-450 monooxygenase system to exert toxic/carcinogenic effects. The present study was car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fd00c73852e84795c0e043932ecff4
https://doi.org/10.1289/ehp.5740

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Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune responses in rats

Autor: Rosana Schafer, Joseph K. H. Ma, Xue-Jun Yin, Jane Y. C. Ma, David N. Weissman, Paul D. Siegel, James M. Antonini, Jenny R. Roberts

Publikováno v: Environmental Health Perspectives

Previously, we showed that diesel exhaust particles (DEPs) suppressed pulmonary clearance of Listeria monocytogenes (Listeria) and inhibited the phagocytosis of alveolar macrophages and their response to Listeria in the secretion of interleukin (IL)-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8476168a8430ae88070f1296c44ef9
https://doi.org/10.1289/ehp.5709

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Effect of Asphalt Fume Inhalation Exposure at Simulated Road Paving Conditions Prior to Bacterial Infection on Lung Defense Responses in Rats

Autor: Vincent Castranova, Xue-Jun Yin, David G. Frazer, Jenny R. Roberts, James M. Antonini, Joseph K. H. Ma, Jane Y. C. Ma, Samuel Stone, A. M. Moseley, Michael D. Taylor

Publikováno v: Inhalation Toxicology. 15:1347-1368

Asphalt fume inhalation has been suspected of affecting immune function in exposed workers. The objective of this study was to evaluate the effect of asphalt exposure on lung immune responses in rats using a bacterial infectivity model. Pathogen-free

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::985481dd082cce7dcc46ad29aa99097a
https://doi.org/10.1080/08958370390241830

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Diesel Exhaust Particle-Induced Alterations of Pulmonary Phase I and Phase II Enzymes of Rats

Autor: E. Kane, A. Rengasamy, Jane Ma, Jane Y. C. Ma, Mark Barger, Vince Castranova

Publikováno v: Journal of Toxicology and Environmental Health, Part A. 66:153-167

Although diesel exhaust particles (DEP) are known to produce pulmonary disorders, the xenobiotic metabolic pathways associated with DEP detoxification and bioactivation remain unclear. In this study, the effect of acute exposure of DEP on phase I and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64623744b42a43ff7caf3a99b15eb7b1
https://doi.org/10.1080/15287390306403

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