Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jane X, Kelly"'
Autor:
Martin J. Smilkstein, Sovitj Pou, Alina Krollenbrock, Lisa A. Bleyle, Rozalia A. Dodean, Lisa Frueh, David J. Hinrichs, Yuexin Li, Thomas Martinson, Myrna Y. Munar, Rolf W. Winter, Igor Bruzual, Samantha Whiteside, Aaron Nilsen, Dennis R. Koop, Jane X. Kelly, Stefan H. I. Kappe, Brandon K. Wilder, Michael K. Riscoe
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-17 (2019)
Abstract Background The potential benefits of long-acting injectable chemoprotection (LAI-C) against malaria have been recently recognized, prompting a call for suitable candidate drugs to help meet this need. On the basis of its known pharmacodynami
Externí odkaz:
https://doaj.org/article/630a94e7fc5a4c469f0ed0eacdad2650
Autor:
Katherine M. Liebman, Steven J. Burgess, Bornface Gunsaru, Jane X. Kelly, Yuexin Li, Westin Morrill, Michael C. Liebman, David H. Peyton
Publikováno v:
Molecules, Vol 25, Iss 9, p 2251 (2020)
Quinoline-based scaffolds have been the mainstay of antimalarial drugs, including many artemisinin combination therapies (ACTs), over the history of modern drug development. Although much progress has been made in the search for novel antimalarial sc
Externí odkaz:
https://doaj.org/article/5e645fe7cb074081a5d7f99a628ec527
Publikováno v:
ACS Infectious Diseases. 7:1956-1968
Robenidine is a veterinary drug used in the poultry industry to treat coccidiosis caused by parasites in the Eimeria genus. Though this compound and related aminoguanidines have recently been studied in other pathogens, the chemotype has not been sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd1d19db69cb7ef67ce7903da2def01
https://doi.org/10.1021/acsinfecdis.1c00001
https://doi.org/10.1021/acsinfecdis.1c00001
Autor:
P Holland, Alday, Erin V, McConnell, Jan M, Boitz Zarella, Rozalia A, Dodean, Papireddy, Kancharla, Jane X, Kelly, J Stone, Doggett
Publikováno v:
ACS Infect Dis
Acridone derivatives, which have been shown to have in vitro and in vivo activity against Plasmodium spp, inhibit Toxoplasma gondii proliferation at picomolar concentrations. Using enzymatic assays, we show that acridones inhibit both T. gondii cytoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::965472a1a703b6539d887f1203a53ac3
https://pubmed.ncbi.nlm.nih.gov/33723998
https://pubmed.ncbi.nlm.nih.gov/33723998
Autor:
Michael K. Riscoe, Yuexin Li, Richard J. Sciotti, Brian Vesely, Aaron Nilsen, Michael W. Mather, Dennis R. Koop, Akhil B. Vaidya, Rolf W. Winter, Martin J. Smilkstein, Qigui Li, Mara Kreishman-Deitrick, Diana Caridha, Lisa Frueh, Robert F. Campbell, Sovitj Pou, Lisa H. Xie, April M. Pershing, Isaac P. Forquer, Jane X. Kelly
Publikováno v:
ACS Infectious Diseases. 3:728-735
ELQ-300 is a preclinical antimalarial drug candidate that is active against liver, blood, and transmission stages of Plasmodium falciparum. While ELQ-300 is highly effective when administered in a low multi-dose regimen, poor aqueous solubility and h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249b65dc64b941bff90c86f25bc6788b
https://doi.org/10.1021/acsinfecdis.7b00062
https://doi.org/10.1021/acsinfecdis.7b00062
Autor:
Mostafa E. Abugrain, Wanli Lu, Corey J. Brumsted, Jane E. Ishmael, Adam W.G. Alani, Taifo Mahmud, Jane X. Kelly, Andrew R. Osborn, Jeffrey D. Serrill, Yuexin Li
Publikováno v:
ChemBioChem. 17:1585-1588
Pactamycin is a bacteria-derived aminocyclitol antibiotic with a wide-range of biological activity. Its chemical structure and potent biological activities have made it an interesting lead compound for drug discovery and development. Despite its unus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9cbd7200f7365b65627b2bf83a2463
https://doi.org/10.1002/cbic.201600261
https://doi.org/10.1002/cbic.201600261
Autor:
Jeffrey D. Serrill, Dong Li, Rebecca A. Medina, Patrick Videau, William H. Gerwick, Edward A. Mitchell, Oliver B. Vining, Philip Proteau, Jane X. Kelly, Jane E. Ishmael, Kerry L. McPhail
Publikováno v:
Journal of Natural Products
Two new cyclic depsipeptides, companeramides A (1) and B (2), have been isolated from the phylogenetically characterized cyanobacterial collection that yielded the previously reported cancer cell toxin coibamide A (collected from Coiba Island, Panama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922003c90493acf618ecde024c409992
http://europepmc.org/articles/PMC4380200
http://europepmc.org/articles/PMC4380200
Autor:
David H. Peyton, Shawheen Shomloo, Westin H. Morrill, Martin J. Smilkstein, Steven J. Burgess, Bornface Gunsaru, Jane X. Kelly, Katherine May Liebman
Publikováno v:
Antimicrobial Agents and Chemotherapy
Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two arom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa26c4e7ac1b45dc25a821591596317
http://europepmc.org/articles/PMC5404532
http://europepmc.org/articles/PMC5404532
Autor:
Sovijja Pou, Michael K. Riscoe, Marie H. Foss, Patrick M. Davidson, Meredith H. Licon, Rolf W. Winter, Georgiana E. Purdy, Julia K. Doh, Jane X. Kelly, Jennifer L. Dunaj, Dennis R. Koop, Rozalia A. Dodean, Yuexin Li, Sovitj Pou
Publikováno v:
ACS infectious diseases. 2(7)
New treatments for tuberculosis infection are critical to combat the emergence of multi-drug and extensively-drug resistant Mycobacterium tuberculosis (Mtb). We report the characterization of a diphenylether modified adamantyl 1,2-diamine that we ref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb485bf5f4bc4127abd6af4eb5879250
https://pubmed.ncbi.nlm.nih.gov/27626102
https://pubmed.ncbi.nlm.nih.gov/27626102
Autor:
Aaron Nilsen, Allison M. Stickles, Rolf W. Winter, Joanne M. Morrisey, Akhil B. Vaidya, Martin J. Smilkstein, Yuexin Li, Sovitj Pou, Michael K. Riscoe, Isaac P. Forquer, Jane X. Kelly
Antimalarial combination therapies play a crucial role in preventing the emergence of drug-resistant Plasmodium parasites. Although artemisinin-based combination therapies (ACTs) comprise the majority of these formulations, inhibitors of the mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0340c1aa1ffb2632473d5013135dd28
https://europepmc.org/articles/PMC4958223/
https://europepmc.org/articles/PMC4958223/
