Výsledky vyhledávání - "Jane Wrigley"

Abstract 87: Recapitulating the orthotopic tumor microenvironment using bioluminescent syngeneic models in immune competent mice for checkpoint inhibitor interrogation

Autor: Jane Wrigley, Rajendra Kumari, Jason R. King, Maya Jetha, Yinfei Yin, Simon Jiang, Joyce Afrakoma Obeng

Publikováno v: Cancer Research. 79:87-87

BACKGROUND: Checkpoint inhibitors have shown promising therapeutic benefit in various cancer types, but more advanced preclinical models are required to combat resistance and evaluate opportunities for combination treatments. Subcutaneous syngeneic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e95bc2fcec8ddd0d24940b697459661
https://doi.org/10.1158/1538-7445.am2019-87

Zobrazit plný text záznamu

Abstract 1060: Establishment of a panel of prostate patient derived xenograft (PDX) models and evaluation of anti-androgen therapy

Autor: Anthony Oakden, Yinfei Yin, Davy Xuesong Ouyang, Rajendra Kumari, Wubin Qian, Bin Fan, Jane Wrigley, Anne T. Collins, Jason Davis, Chira Roberts, Jie Cai

Publikováno v: Cancer Research. 79:1060-1060

BACKGROUND: Prostate cancer is one of the most common cancer worldwide with limited treatment options and very poor prognosis. Surgery, chemo therapy such as docetaxel (Taxotere®) and targeted therapies such as abiraterone (Zytiga®) and enzalutamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da52b09e83795f1e1855ef88276b1281
https://doi.org/10.1158/1538-7445.am2019-1060

Zobrazit plný text záznamu

The Role of the Legal Nurse Consultant in Brachial Plexus Injury: A Case Study

Autor: Jane Wrigley, Roslynn Mertens

Publikováno v: Newborn and Infant Nursing Reviews. 10:138-142

Legal action against nurses and physicians regarding obstetrics and neonatal patients remains a significant concern when the outcome of a pregnancy is not as expected. Obstetric-related cases historically have sustained the highest median payment amo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fcffc2a45c2a0e974248bc759254178
https://doi.org/10.1053/j.nainr.2010.06.009

Zobrazit plný text záznamu

Abstract 5033: Patient-derived xenograft screening in a three-dimensional tumor growth assay incorporating stromal elements to recapitulate the human tumor microenvironment

Autor: Rajendra Kumari, Sumanjeet Malhi, Jamie Wood, Yinfei Yin, Stephanie Morton, Jane Wrigley, Louise Wainwright, Simon H Jiang

Publikováno v: Cancer Research. 78:5033-5033

BACKGROUND: Pre-clinical tumour models lack human stromal cells and are inadequate for the assessment of novel tumour microenvironment targeted therapies. An increase in combination opportunities requires a higher throughput in vitro assay that utili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de25725add89fca9ad1b65d3a95742a3
https://doi.org/10.1158/1538-7445.am2018-5033

Zobrazit plný text záznamu

Abstract A213: Three-dimensional tumor growth assay for patient-derived tissue and cell line models incorporating stromal elements for screening

Autor: Stephanie Morton, Sumanjeet Malhi, Jane Wrigley, Jason R. King, Lucy Harris, Simon Jiang, Yinfei Yin, Louise Wainwright, Jamie Wood, Rajendra Kumari

Publikováno v: Molecular Cancer Therapeutics. 17:A213-A213

Background: Preclinical in vitro and in vivo tumor models lack human stromal cells and are inadequate for the assessment of novel tumor microenvironment-targeted therapies. Here we report on a 3D-tumor growth assay (3D-TGA) in which patient-derived t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71297196a6ea3c428b5aba99bf69bccb
https://doi.org/10.1158/1535-7163.targ-17-a213

Zobrazit plný text záznamu

Abstract A010: Interrogation of checkpoint inhibitors in bioluminescent orthotopic syngeneic models of hepatocellular carcinoma

Autor: Jason R. King, Louise Wainwright, Jamie Wood, Louise Woolley, Jane Wrigley, Simon Jiang, Vicky Lacey, Nektaria Papadopoulou, Rajendra Kumari, Sumanjeet Malhi

Publikováno v: Molecular Cancer Therapeutics. 17:A010-A010

Background: Hepatocellular carcinoma (HCC) is an aggressive disease with limited therapeutic treatment options. Checkpoint inhibitors are widely being evaluated in numerous cancers including HCC, but suitable preclinical models are required. Subcutan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0cf94b758c300dec976f5770a8c8e0d
https://doi.org/10.1158/1535-7163.targ-17-a010

Zobrazit plný text záznamu

Abstract 2824: Validation of a panel of patient-derived xenograft models for prostate caner and cell line models for preclinical drug evaluation

Autor: Rajendra Kumari, Andrew N. J. McKenzie, Kelly Jones, Nektaria Papadopoulou, Jason R. King, Jane Wrigley, Anne T. Collins, Louise Wainwright

Publikováno v: Cancer Research. 77:2824-2824

Background: Prostate cancer is the second most common cancer worldwide for males, and the fourth most common cancer overall, with more than a million new cases diagnosed. However, progress toward understanding the biology of prostate cancer and the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::062cc81601fac9fea44b812a0c5c0864
https://doi.org/10.1158/1538-7445.am2017-2824

Zobrazit plný text záznamu

Improved Vascular Endothelial Function After Oral B Vitamins

Autor: John C. Chambers, Jane Wrigley, Omar Obeid, Helga Refsum, Per Magne Ueland, Jaspal S. Kooner

Publikováno v: Circulation. 102:2479-2483

Background —Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of hom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538fbdbfbba4017f0cdbbaeabe1f0168
https://doi.org/10.1161/01.cir.102.20.2479

Zobrazit plný text záznamu

Abstract A140: Check point inhibitor modulation of tumor microenvironment at orthotopic and metastatic sites using bioluminescent syngeneic cell line models in immune competent mice

Autor: Nektaria Papadopoulou, Neil Williams, Russell Garland, Simon Jiang, Jane Wrigley, Andrew McKenzie, Rajendra Kumari, Kelly Jones

Publikováno v: Cancer Immunology Research. 4:A140-A140

Introduction: Syngeneic models are widely used to model the impact of cancer immunotherapy on tumor growth and tumor invading leucocytes (TILs), and the majority of such work is typically carried out in the subcutaneous setting. However, orthotopic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc2ba472d126485cd4666dc2c26ad7c6
https://doi.org/10.1158/2326-6066.imm2016-a140

Zobrazit plný text záznamu

Abstract 3994: Immune competent syngeneic models demonstrate additive effects of combination strategies using checkpoint immunotherapy and inducers of immunogenic cell death (ICD)

Autor: Nektaria Papadopoulou, Qian Shi, Neil Williams, Jane Wrigley, Andrew McKenzie, Simon Jiang, Russell Garland, Rajendra Kumari, Yinfei Yin, Jason R. King

Publikováno v: Cancer Research. 76:3994-3994

INTRODUCTION: Recent progress in the field of cancer immunotherapy have made it possible to translate several emerging immunostimulatory strategies, e.g. anti-CTLA-4, and anti-PD-1 into the clinic resulting in promising clinical benefits. In addition

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e599db91f8de71b0aaf3ec6ca5514988
https://doi.org/10.1158/1538-7445.am2016-3994

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání