Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jane Wilmot"'
Autor:
Jill Clark, Bernard Rees Smith, Jadwiga Furmaniak, Yang Li, Paul W. Sanders, Jane Sanders, Jane Wilmot
Publikováno v:
Autoimmunity Highlights
Background The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies. Methods The preclinical toxicology assessment following we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e8c6fc7ed8cd2d2b0ac01e443f8760
http://europepmc.org/articles/PMC7065368
http://europepmc.org/articles/PMC7065368
Autor:
Stuart Young, Emily Pearson, Katarzyna Kabelis, Matthew Holly, Jill Clark, Jane Sanders, Jane Wilmot, Stuart Baker, Ricardo Núñez Miguel, Bernard Rees Smith, Samuel C. Reddington, Francesca Cole, Monika Chlebowska, Andrew Sullivan, Emma Roberts, Matthew Clue, Daniel Thomas, Jadwiga Furmaniak, Michele Evans, Jennifer Miller-Gallacher, Michael Powell, Paul W. Sanders
Publikováno v:
Journal of molecular endocrinology. 62(3)
The crystal structures of the thyroid-stimulating hormone receptor (TSHR) leucine-rich repeat domain (amino acids 22–260; TSHR260) in complex with a stimulating human monoclonal autoantibody (M22TM) and in complex with a blocking human autoantibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f8ef16ea669774cef4239e110dbbfd
https://pubmed.ncbi.nlm.nih.gov/30689545
https://pubmed.ncbi.nlm.nih.gov/30689545
Autor:
Katarzyna Kabelis, Paul W. Sanders, Bernard Rees Smith, Jane Wilmot, Michele Evans, Jadwiga Furmaniak, Jane Sanders, Stuart Young, Jill Clark
Publikováno v:
Auto-Immunity Highlights
Purpose To study in vivo effects of the human monoclonal TSH receptor (TSHR) autoantibodies M22 (stimulating type) and K1-70 (blocking type) on thyroid hormone levels in rats. Methods Serum levels of total T4, free T4, M22 and K1-70 were measured fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f550e7142b52d9379f04f9fcaeac2e3
https://doi.org/10.1007/s13317-011-0025-9
https://doi.org/10.1007/s13317-011-0025-9
Autor:
Tonya Richards, Jane Sanders, Katarzyna Kabelis, Jane Wilmot, Tetsuya Tagami, Jill Clark, Bernard Rees Smith, Emma Roberts, Xiaoling Hu, Stuart Young, Jadwiga Furmaniak, Alastair Collyer, Paul W. Sanders, Michele Evans, Sabrina Holl
Publikováno v:
Clinical Endocrinology. 73:404-412
Summary Objective Patients who appear to have both stimulating and blocking TSHR autoantibodies in their sera have been described, but the two activities have not been separated and analysed. We now describe the isolation and detailed characterizatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1eaa7dd319bb204f05290c06f6939e4
https://doi.org/10.1111/j.1365-2265.2010.03831.x
https://doi.org/10.1111/j.1365-2265.2010.03831.x
Autor:
Rebecca Harris, Jane Sanders, Emma Roberts, Corrado Betterle, Paul W. Sanders, Kasemsri Small, Jane Wilmot, Stuart Young, Renato Zanchetta, Shu Chen, Anshu Bhardwaja, Angela Kiddie, Michele Evans, Graziella Coco, Bernard Rees Smith, Jadwiga Furmaniak, Sara Summerhayes, Magnus Reeve, Tonya Richards, Hayley Platt
Publikováno v:
Thyroid. 18:735-746
Human monoclonal autoantibodies (MAbs) are valuable tools to study autoimmune responses. To date only one human MAb to the thyrotropin (TSH) receptor (TSHR) with stimulating activity has been available. We now describe the detailed characterization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc62be3d0cb8b630f7d196dbf72191f
https://doi.org/10.1089/thy.2007.0327
https://doi.org/10.1089/thy.2007.0327
Autor:
Ricardo Núñez Miguel, Paul W. Sanders, Katarzyna Kabelis, Xiaoling Hu, Stuart Young, Jane Sanders, Michele Evans, Bernard Rees Smith, Jadwiga Furmaniak, Emma Roberts, Jill Clark, Jane Wilmot
Publikováno v:
Journal of molecular endocrinology. 49(2)
Binding of a new thyroid-stimulating human monoclonal autoantibody (MAb) K1–18 to the TSH receptor (TSHR) leucine-rich domain (LRD) was predicted using charge–charge interaction mapping based on unique complementarities between the TSHR in intera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::464c1815bbd990146a4d13cd2378a4fa
https://pubmed.ncbi.nlm.nih.gov/22829655
https://pubmed.ncbi.nlm.nih.gov/22829655
Autor:
Ricardo Núñez Miguel, Michael Powell, Xiaoling Hu, Stuart Baker, Bernard Rees Smith, Andrew Sullivan, Katarzyna Kabelis, Stuart Young, Jane Wilmot, Emma Roberts, Jadwiga Furmaniak, Jill Clark, Jane Sanders, Michele Evans, Paul W. Sanders
Publikováno v:
Journal of Molecular Endocrinology.
A complex of the TSH receptor extracellular domain (amino acids 22-260; TSHR260) bound to a blocking-type human monoclonal autoantibody (K1-70) was purified, crystallised and the structure solved at 1.9 Å resolution. K1-70 Fab binds to the concave s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8c8bef25b207163194e95be374af18
https://doi.org/10.1530/jme-10-0127
https://doi.org/10.1530/jme-10-0127
Autor:
Michele, Evans, Jane, Sanders, Tetsuya, Tagami, Paul, Sanders, Stuart, Young, Emma, Roberts, Jane, Wilmot, Xiaoling, Hu, Katarzyna, Kabelis, Jill, Clark, Sabrina, Holl, Tonya, Richards, Alastair, Collyer, Jadwiga, Furmaniak, Bernard Rees, Smith
Publikováno v:
Clinical endocrinology. 73(3)
Patients who appear to have both stimulating and blocking TSHR autoantibodies in their sera have been described, but the two activities have not been separated and analysed. We now describe the isolation and detailed characterization of a blocking ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::423f17be53e9e8ba0ad2b0ea68fed153
https://pubmed.ncbi.nlm.nih.gov/20550534
https://pubmed.ncbi.nlm.nih.gov/20550534