Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Jane W. Symington"'
Autor:
Akhil Kumar, Indira U. Mysorekar, Adam S. B. Ross, Hao Wei Chang, Jane W. Symington, Kyle A. Bauckman, Joy Twentyman, Marianne M. Ligon, Bisiayo E. Fashemi, Caihong Wang, Gael Scholtes, Ramnik J. Xavier
50% of Caucasians carry a Thr300Ala variant (T300A) in the protein encoded by the macroautophagy/autophagy gene ATG16L1. Here, we show that the T300A variant confers protection against urinary tract infections (UTIs), the most common infectious disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0626398b2e9f99eea62ee16f934bad
https://europepmc.org/articles/PMC6351132/
https://europepmc.org/articles/PMC6351132/
Autor:
Joel D. Schilling, Jane W. Symington, N Owusu-Boaitey, Caihong Wang, Joy Twentyman, G Núñez, Indira U. Mysorekar, Reto A. Schwendener
Publikováno v:
Mucosal immunology
Urinary tract infections (UTIs) are frequent, commonly recurrent, and costly. Deficiency in a key autophagy protein, ATG16L1, protects mice from infection with the predominant bacterial cause of UTIs, Uropathogenic E. coli (UPEC). Here, we report tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af385a85da843ba8c907cc028b842354
https://doi.org/10.1038/mi.2015.7
https://doi.org/10.1038/mi.2015.7
Publikováno v:
Infection and Immunity. 81:733-739
Recurrent urinary tract infections (UTIs), primarily caused by uropathogenic Escherichia coli (UPEC), annually affect over 13 million patients in the United States. Menopausal women are disproportionally susceptible, suggesting estrogen deficiency is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c58c01ad54e3a0188441f6e6d73cfb7
https://doi.org/10.1128/iai.01234-12
https://doi.org/10.1128/iai.01234-12
Publikováno v:
Autophagy. 8(11)
Autophagy is generally considered to be antipathogenic. The autophagy gene ATG16L1 has a commonly occurring mutation associated with Crohn disease (CD) and intestinal cell abnormalities. Mice hypomorphic for ATG16L1 (ATG16L1(HM)) recreate specific fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28b8ed78ea46fc86ecd5c9ca9029f59
https://pubmed.ncbi.nlm.nih.gov/22874553
https://pubmed.ncbi.nlm.nih.gov/22874553
Autor:
Jane W. Symington, Qunyuan Zhang, Herbert W. Virgin, Ken Cadwell, Indira U. Mysorekar, Caihong Wang, Graziella R Mendonsa
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 109(27)
Urinary tract infection (UTI), a frequent and important disease in humans, is primarily caused by uropathogenic Escherichia coli (UPEC). UPEC forms acute cytoplasmic biofilms within superficial urothelial cells and can persist by establishing membran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a07ae941f16375796a46ec3481c60ee
https://pubmed.ncbi.nlm.nih.gov/22777289
https://pubmed.ncbi.nlm.nih.gov/22777289