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Mutation of an Influenza Virus Polymerase 3' RNA Promoter Binding Site Inhibits Transcription Elongation

Autor: Jane Sharps, Alexander P Walker, Ervin Fodor

Publikováno v: J Virol

Influenza viruses encode a viral RNA-dependent RNA polymerase (FluPol), which is responsible for transcribing and replicating the negative-sense viral RNA (vRNA) genome. FluPol transcribes vRNA using a host-capped mRNA primer and replicates it by syn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de403f6e198a5473737f3dd6e32e584d
https://pubmed.ncbi.nlm.nih.gov/32295915

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Structures of influenza A virus RNA polymerase offer insight into viral genome replication

Autor: D. Karia, Haitian Fan, Jonathan M. Grimes, Els Pardon, Narin Hengrung, J.R. Keown, Loic Carrique, Jane Sharps, Alexander P Walker, I. Serna Martin, Ervin Fodor, Jan Steyaert

Publikováno v: Nature

Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from the transmission of novel zoonotic influenza A viruses to humans1,2. Influenza A viruses contain a segmented negative-sense RNA genome, which is transcribed and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c378684d91cb9bdd8d703d1dcf86c2
https://pubmed.ncbi.nlm.nih.gov/31485076

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Mini viral RNAs act as innate immune agonists during influenza virus infection

Autor: David L.V. Bauer, Aartjan J. W. te Velthuis, Jurre Y. Siegers, Marian J. Killip, Richard E. Randall, Hui-Ling Yen, Debby van Riel, Rebecca L. Y. Fan, Maria José Oliva-Martín, Joshua C. D. Long, Emmie de Wit, Jane Sharps, Ervin Fodor, Hollie French, Leo L.M. Poon

Publikováno v: Nature Microbiology, 3(11), 1234-1242. Nature Publishing Group
Nature microbiology

We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics (funded by Wellcome Trust grant 090532/Z/09/Z) for the generation of adapter-ligated mvRNA sequencing data. This work was supported by the Wellcome Trust gran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2051e5158edbbdbc666562d5a2aa5e
https://hdl.handle.net/10023/19928

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A Mechanism for the Activation of the Influenza Virus Transcriptase

Autor: Itziar Serna Martin, Narin Hengrung, Max Renner, Jane Sharps, Mónica Martínez-Alonso, Simonas Masiulis, Jonathan M. Grimes, Ervin Fodor

Publikováno v: Molecular Cell

Summary Influenza virus RNA polymerase (FluPol), a heterotrimer composed of PB1, PB2, and PA subunits (P3 in influenza C), performs both transcription and replication of the viral RNA genome. For transcription, FluPol interacts with the C-terminal do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c9cfa9b2d2a9490d82bb61c2e750d0
https://pubmed.ncbi.nlm.nih.gov/29910112

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A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase inhibits endonucleolytic cleavage of capped RNAs

Autor: George G. Brownlee, Ervin Fodor, Jane Sharps, Pierre Fechter, Mandy Crow, Louise J. Mingay, Tao Deng

The influenza A virus RNA-dependent RNA polymerase consists of three subunits—PB1, PB2, and PA. The PB1 subunit is the catalytically active polymerase, catalyzing the sequential addition of nucleotides to the growing RNA chain. The PB2 subunit is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5defa0aa5c569ab0ef0d4e65f8d27f
https://doi.org/10.1128/jvi.76.18.8989-9001.2002

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Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies

Autor: Johann C. von Kirchbach, Ervin Fodor, Eva M. Loucaides, Paul Digard, Ágnes Foeglein, Jane Sharps

Publikováno v: Loucaides, E M, von Kirchbach, J C, Foeglein, A, Sharps, J, Fodor, E & Digard, P 2009, ' Nuclear dynamics of influenza A virus ribonucleoproteins revealed by live-cell imaging studies ', Virology, vol. 394, no. 1, pp. 154-163 . https://doi.org/10.1016/j.virol.2009.08.015
Virology

The negative sense RNA genome of influenza A virus is transcribed and replicated in the nuclei of infected cells by the vital RNA polymerase. Only four viral polypeptides are required but multiple cellular components are potentially involved. We used

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ed67096acae2125e9bf2915dd3bdf9
https://doi.org/10.1016/j.virol.2009.08.015

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Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication

Autor: George G. Brownlee, Jane Sharps, Tao Deng

Publikováno v: Journal of General Virology. 87:3373-3377

Both transcription and replication of the influenza virus RNA genome are catalysed by a virus-specific RNA polymerase. Recently, anin vitroassay, based on the synthesis of pppApG, for the initiation of replication by recombinant RNA polymerase in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818c031384945b71714bac1e1b238eef
https://doi.org/10.1099/vir.0.82199-0

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Two Aromatic Residues in the PB2 Subunit of Influenza A RNA Polymerase Are Crucial for Cap Binding

Autor: Louise J. Mingay, George G. Brownlee, Pierre Fechter, Ervin Fodor, Anna L Chambers, Jane Sharps

Publikováno v: Journal of Biological Chemistry. 278:20381-20388

mRNAs are capped at their 5′-end by a unique cap structure containing N7-methyl guanine. Recognition of the cap structure is of paramount importance in some of the most central processes of gene expression as well as in some viral processes, such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12425efa6f86aa4dcdad0ea31ce20f03
https://doi.org/10.1074/jbc.m300130200

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