Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Jane S Paulsen"'
Publikováno v:
Frontiers in Neuroinformatics, Vol 10 (2016)
The creation of high-quality medical imaging reference atlas datasets with consistent dense anatomical region labels is a challenging task. Reference atlases have many uses in medical image applications and are essential components of atlas-based seg
Externí odkaz:
https://doaj.org/article/dae850304329452080a0ac44c02301af
Autor:
Florian Holtbernd, Chris C Tang, Andrew Feigin, Vijay Dhawan, Maria Felice Ghilardi, Jane S Paulsen, Mark Guttman, David Eidelberg
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154742 (2016)
Neurocognitive decline, including deficits in motor learning, occurs in the presymptomatic phase of Huntington's disease (HD) and precedes the onset of motor symptoms. Findings from recent neuroimaging studies have linked these deficits to alteration
Externí odkaz:
https://doaj.org/article/8d319b3009774f7fbdf3df5aec5a8dc2
Publikováno v:
Frontiers in Neuroscience, Vol 9 (2015)
Multicenter longitudinal neuroimaging has great potential to provide efficient and consistent biomarkers for research of neurodegenerative diseases and aging. In rare disease studies it is of primary importance to have a reliable tool that performs c
Externí odkaz:
https://doaj.org/article/4a26e91bf52e499db2b6482be91f0088
Autor:
Jane S Paulsen, Jeffrey D Long, Hans J Johnson, Elizabeth H Aylward, Christopher A Ross, Janet K Williams, Martha A Nance, Cheryl J Erwin, Holly K Westervelt, Deborah Lynn Harrington, H Jeremy Bockholt, Ying eZhang, Elizabeth A McCusker, Edmund M Chiu, Peter K Panegyres
Publikováno v:
Frontiers in Aging Neuroscience, Vol 6 (2014)
There is growing consensus that intervention and treatment of Huntington disease (HD) should occur at the earliest stage possible. Various early-intervention methods for this fatal neurodegenerative disease have been identified, but preventive clinic
Externí odkaz:
https://doaj.org/article/0e6713759429493c887533d49fd6d3e9
Autor:
Kevin M Biglan, Ying eZhang, Jeffery eLong, Michael eGeschwind, Gail eKang, Annie eKilloran, Wenjing eLu, Elizabeth eMcCusker, James A Mills, Lynn A Raymond, Claudia eTesta, Joanne eWojcieszek, Jane S Paulsen
Publikováno v:
Frontiers in Aging Neuroscience, Vol 5 (2013)
Participants with the gene expansion for Huntington disease (HD) but not yet diagnosed were evaluated annually. Unidimensional diagnosis (UD) was a motor diagnosis defined as a diagnostic confidence level (DCL) of 4 (unequivocal motor signs, ≥99% c
Externí odkaz:
https://doaj.org/article/79656b730b5e4e75a0303cdb3dead42b
Autor:
Mohsen Ghofrani-Jahromi, Govinda R. Poudel, Adeel Razi, Pubu M. Abeyasinghe, Jane S. Paulsen, Sarah J. Tabrizi, Susmita Saha, Nellie Georgiou-Karistianis
Publikováno v:
NeuroImage: Clinical, Vol 43, Iss , Pp 103650- (2024)
Background: In Huntington’s disease clinical trials, recruitment and stratification approaches primarily rely on genetic load, cognitive and motor assessment scores. They focus less on in vivo brain imaging markers, which reflect neuropathology wel
Externí odkaz:
https://doaj.org/article/c5bd680ba33d418db012ceb4407de126
Autor:
Leonard L. Sokol, Jonathan P. Troost, Benzi M. Kluger, Allison J. Applebaum, Jane S. Paulsen, Danny Bega, Samuel Frank, Joshua M. Hauser, Nicholas R. Boileau, Colin A. Depp, David Cella, Noelle E. Carlozzi
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1668-1679 (2021)
Abstract Objective Previous work in Huntington’s disease (HD) has shown that a sense of meaning and purpose (M&P) is positively associated with positive affect and well‐being (PAW); however, it was unknown whether HD‐validated patient‐reporte
Externí odkaz:
https://doaj.org/article/4a1ac452e70f45678c1ded6334db1cd9
Autor:
Peter A. Wijeratne, Eileanoir B. Johnson, Sarah Gregory, Nellie Georgiou-Karistianis, Jane S. Paulsen, Rachael I. Scahill, Sarah J. Tabrizi, Daniel C. Alexander
Publikováno v:
Frontiers in Big Data, Vol 4 (2021)
Understanding the order and progression of change in biomarkers of neurodegeneration is essential to detect the effects of pharmacological interventions on these biomarkers. In Huntington’s disease (HD), motor, cognitive and MRI biomarkers are curr
Externí odkaz:
https://doaj.org/article/478832a5997e44388211a35b3a889871
Autor:
Ying Zhang, Junyi Zhou, Carissa R. Gehl, Jeffrey D. Long, Hans Johnson, Vincent A. Magnotta, Daniel Sewell, Kathleen Shannon, Jane S. Paulsen
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
As one of the clinical triad in Huntington's disease (HD), cognitive impairment has not been widely accepted as a disease stage indicator in HD literature. This work aims to study cognitive impairment thoroughly for prodromal HD individuals with the
Externí odkaz:
https://doaj.org/article/6c4b5b9559ff4e88b8065a07bd9b7360
Autor:
Laura B, Eisenmenger, Anthony, Peret, Bolanle M, Famakin, Alma, Spahic, Grant S, Roberts, Jeremy H, Bockholt, Kevin M, Johnson, Jane S, Paulsen
Publikováno v:
Translational Research. 254:41-53
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by progressive neurodegeneration and cognitive decline. Understanding the pathophysiology underlying AD is paramount for the management of individuals at risk of and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d0732048c2b4e8499117dc009c092c
https://doi.org/10.1016/j.trsl.2022.12.003
https://doi.org/10.1016/j.trsl.2022.12.003