Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jane R. Noble"'
Autor:
Lily I. Huschtscha, Christine E. Napier, Jane R. Noble, Kylie Bower, Amy Y.M. Au, Hamish G. Campbell, Antony W. Braithwaite, Roger R. Reddel
Publikováno v:
BioTechniques, Vol 53, Iss 4, Pp 239-244 (2012)
Here we describe a method for growing fibroblasts from human skin explants that increases the number of cells obtained by up to two orders of magnitude, thus increasing the amount of material available for research and diagnostic purposes and potenti
Externí odkaz:
https://doaj.org/article/bc987da89fe24c3089e5110360f03c75
Autor:
Alexandre de Nonneville, Sébastien Salas, François Bertucci, Alexander P Sobinoff, José Adélaïde, Arnaud Guille, Pascal Finetti, Jane R Noble, Dimitri Churikov, Max Chaffanet, Elise Lavit, Hilda A Pickett, Corinne Bouvier, Daniel Birnbaum, Roger R Reddel, Vincent Géli
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, 2022, 14, ⟨10.15252/emmm.202215859⟩
EMBO Molecular Medicine, 2022, 14, ⟨10.15252/emmm.202215859⟩
International audience; In some types of cancer, telomere length is maintained by the alternative lengthening of telomeres (ALT) mechanism. In many ALT cancers, the a-thalassemia/mental retardation syndrome X-linked (ATRX) gene is mutated leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0344da41a81e0e02ff919628924c5d
https://pubmed.ncbi.nlm.nih.gov/35920001
https://pubmed.ncbi.nlm.nih.gov/35920001
Autor:
Eugene H. Y. Choi, Sonja Frölich, Roger D. Everett, Jane R. Noble, Ted Wong, Christine E. Napier, Roger R. Reddel, Anthony J. Cesare, Erdahl Teber, Mingqi Han
Publikováno v:
Journal of Cell Science
Cancers that utilize the alternative lengthening of telomeres (ALT) mechanism for telomere maintenance are often difficult to treat and have a poor prognosis. They are also commonly deficient for expression of ATRX protein, a repressor of ALT activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5724fe1b51ff6f6733263f53dfe2d52
https://doi.org/10.1242/jcs.222349
https://doi.org/10.1242/jcs.222349
Autor:
Jane R. Noble, Adam J. Harvey, Lily I. Huschtscha, Eric A. Hendrickson, Kylie Bower, Christine E. Napier, Roger R. Reddel
Publikováno v:
Oncotarget
The unlimited proliferation of cancer cells requires a mechanism to prevent telomere shortening. Alternative Lengthening of Telomeres (ALT) is an homologous recombination-mediated mechanism of telomere elongation used in tumors, including osteosarcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55834bff6f18d5cb4f8cb32fd0727383
http://europepmc.org/articles/PMC4599288
http://europepmc.org/articles/PMC4599288
Autor:
Roger R. Reddel, Catherine M. Watson, Hilda A. Pickett, Patrick P.L. Tam, Jane R. Noble, Axel A. Neumann
Publikováno v:
Genes & Development. 27:18-23
Some cancers use alternative lengthening of telomeres (ALT), a mechanism whereby new telomeric DNA is synthesized from a DNA template. To determine whether normal mammalian tissues have ALT activity, we generated a mouse strain containing a DNA tag i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a116b889b8bd8f3f22f07ab707329d
https://doi.org/10.1101/gad.205062.112
https://doi.org/10.1101/gad.205062.112
Autor:
Lily I. Huschtscha, Jonathan D. Moore, Hamish Campbell, Antony W. Braithwaite, Jane R. Noble, Roger R. Reddel, Janice A. Royds
Publikováno v:
Journal of Cell Science. 122:2989-2995
In normal cells, p53 protein is maintained at low levels, but the levels increase after stress or inappropriate growth signals to coordinate growth arrest or apoptosis. Human mammary epithelial cells (HMECs) are unusual in that they exhibit two phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e10e60d7fc89b074349e2733e769828
https://doi.org/10.1242/jcs.044107
https://doi.org/10.1242/jcs.044107
Publikováno v:
Experimental Cell Research. 256:122-130
Immunofluorescent staining of mitotic centrosomes and spindles by anti-p53 antibodies was observed in the embryonic chick epiblast by epifluorescence microscopy and in three human cancer cell lines, an SV40-immortalized cell line, and a normal human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a192cf1f90c1c3ea74b177d12a1f63c0
https://doi.org/10.1006/excr.2000.4800
https://doi.org/10.1006/excr.2000.4800
Autor:
Miriam Hulsbeek, Andy C.-M. Chang, Jackie B.M. Janosi, Debora de Jong, Jane R. Noble, Katherine J. Jeffrey, Roger R. Reddel
Publikováno v:
Molecular and Cellular Endocrinology. 112:241-247
Stanniocalcin is a glycoprotein hormone previously considered present only in bony fish where it is secreted by the corpuscles of Stannius, endocrine organs involved in Ca2+ homeostasis. In fish, stanniocalcin was thought to be an adaptation for Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1c49ae22c9b8fd8cbe3aa3f275536e
https://doi.org/10.1016/0303-7207(95)03601-3
https://doi.org/10.1016/0303-7207(95)03601-3
Autor:
Eileen M. Rogan, Kenneth Maclean, Jane R. Noble, Tracy M. Bryan, Roger R. Reddel, Andy C.-M. Chang, Noel J. Whitaker
Publikováno v:
Radiation Oncology Investigations. 3:299-306
Spontaneous immortalization of fibroblasts containing an inherited mutation of one p53 allele was associated with loss of the wild-type p53 allele and loss of p16INK4 gene expression, but this combination of genetic events was insufficient for immort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb705126d32dcd96577ef17c53cbefb
https://doi.org/10.1002/roi.2970030610
https://doi.org/10.1002/roi.2970030610
Autor:
Christine E. Napier, Roger R. Reddel, Antony W. Braithwaite, Amy Y.M. Au, Jane R. Noble, Lily I. Huschtscha, Hamish Campbell, Kylie Bower
Publikováno v:
BioTechniques. 53(4)
Here we describe a method for growing fibroblasts from human skin explants that increases the number of cells obtained by up to two orders of magnitude, thus increasing the amount of material available for research and diagnostic purposes and potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400da771ad13dacb5b087ad67ffb56d4
https://pubmed.ncbi.nlm.nih.gov/23046507
https://pubmed.ncbi.nlm.nih.gov/23046507