Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jane R. Engler"'
Autor:
Jane R. Engler, Andrew C.W. Zannettino, Charles G. Bailey, John E.J. Rasko, Timothy P. Hughes, Deborah L. White
Publikováno v:
Haematologica, Vol 96, Iss 2 (2011)
Background Despite the excellent responses to imatinib therapy observed in patients with chronic phase chronic myeloid leukemia, approximately 25% of patients display primary resistance or suboptimal response. The OCT-1 activity in mononuclear cells
Externí odkaz:
https://doaj.org/article/4f5807c0b6b5416398d8fb83bbf5d47b
Autor:
Joanna J. Phillips, William A. Weiss, Monika E. Hegi, Albert Lai, William H. Yong, Theodore P. Nicolaides, C. David James, Joseph T.C. Shieh, Mitchel S. Berger, Andrew W. Bollen, Michael Prados, Linda M. Liau, Timothy F. Cloughesy, Erin F. Simonds, Kan V. Lu, Henry Gong, Anupam Kumar, Katharine Y. Chen, Jane R. Engler, Olle R. Lindberg, Andrew McKinney
Supplementary Figure S1 shows increased invasion is specific to EGFR inhibition, increased ALDH1A1 expression is not specific to erlotinib but also occurs with AG1478 and lapatinib, and EGFR inhibition increases expression of several genes implicated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00141c8ad56ed4fbd4e04e650a02b942
https://doi.org/10.1158/1535-7163.22506199
https://doi.org/10.1158/1535-7163.22506199
Autor:
Joanna J. Phillips, William A. Weiss, Monika E. Hegi, Albert Lai, William H. Yong, Theodore P. Nicolaides, C. David James, Joseph T.C. Shieh, Mitchel S. Berger, Andrew W. Bollen, Michael Prados, Linda M. Liau, Timothy F. Cloughesy, Erin F. Simonds, Kan V. Lu, Henry Gong, Anupam Kumar, Katharine Y. Chen, Jane R. Engler, Olle R. Lindberg, Andrew McKinney
Amplification of the epidermal growth factor receptor gene (EGFR) represents one of the most commonly observed genetic lesions in glioblastoma (GBM); however, therapies targeting this signaling pathway have failed clinically. Here, using human tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab7e13d5ba0dbfc1f50b929a8ae3a3d
https://doi.org/10.1158/1535-7163.c.6538321.v1
https://doi.org/10.1158/1535-7163.c.6538321.v1
Publikováno v:
Methods in Molecular Biology ISBN: 9781493917136
Methods in Molecular Biology ISBN: 9781071613979
Methods in Molecular Biology ISBN: 9781071613979
Extracellular sulfatases (SULF1 and SULF2) selectively remove 6-O-sulfate groups (6OS) from heparan sulfate proteoglycans (HSPGs) and by this process control important interactions of HSPGs with extracellular factors including morphogens, growth fact
Autor:
Katharine Chen, Vy M. Tran, Olle R. Lindberg, Anders Persson, Jane R. Engler, Andrew McKinney, Anna Wade, Joanna J. Phillips
Publikováno v:
Molecular cancer research : MCR, vol 15, iss 11
Glioblastoma (GBM) is the most common primary malignant brain tumor of adults and confers a poor prognosis due, in part, to diffuse invasion of tumor cells. Heparan sulfate (HS) glycosaminoglycans, present on the cell surface and in the extracellular
Autor:
Aaron E. Robinson, Joanna J. Phillips, Emmanuelle Huillard, Olle R. Lindberg, Andrew J. Ewald, Annette M. Molinaro, Joseph T. Shieh, Henry Gong, Andrew McKinney, Gayane Koshkakaryan, C. David James, Jane R. Engler
Publikováno v:
Oncotarget, vol 7, iss 48
Oncotarget
Oncotarget
Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9b728131a8660c665c4fc4e984fda1
https://escholarship.org/uc/item/36x8n3x3
https://escholarship.org/uc/item/36x8n3x3
Autor:
Anna Wade, Joanna J. Phillips, Claudia Petritsch, Aaron E. Robinson, C. David James, Jane R. Engler
Publikováno v:
The FEBS journal, vol 280, iss 10
Glioblastoma, a malignant brain cancer, is characterized by abnormal activation of receptor tyrosine kinase signalling pathways and a poor prognosis. Extracellular proteoglycans, including heparan sulfate and chondroitin sulfate, play critical roles
Autor:
Aaron E. Robinson, Ivan Smirnov, Mitchel S. Berger, J. Graeme Hodgson, Annette M. Molinaro, Nalin Gupta, Joanna J. Phillips, Jane R. Engler, C. David James
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43339 (2012)
PLoS ONE
PLoS ONE
Glioblastoma (GBM) is a highly malignant brain tumor with a dismal prognosis. Gene expression profiling of GBM has revealed clinically relevant tumor subtypes, and this provides exciting opportunities to better understand disease pathogenesis. Result
Publikováno v:
Neuro-Oncology. 17:v227.5-v228
Glioblastoma (GBM) is a heterogeneous disease and can exhibit a diversity of cell behaviors and responses to therapy, even when driven by a similar set of oncogenic alterations. Using a murine model for glioma based on the genetic manipulation of neu
Autor:
Joseph T. Shieh, Jane R. Engler, Andrew McKinney, Joanna J. Phillips, Olle R. Lindberg, Henry Gong
Publikováno v:
Neuro-Oncology. 17:v61.2-v61
Therapeutic targeting of EGFR signaling in GBM has had largely disappointing results in the clinic. We sought to identify cell vulnerabilities that could be targeted in combination with EGFR. Using a murine model for GBM, primary patient-derived xeno