Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jane R, Connor"'
Autor:
Daniel Pacheco, Yasuki Ito, Jane R. Connor, Bruce A. Berkowitz, Timothy S. Kern, Jessica Liggett, Andres Seidner, Yunpeng Du, Robin Roberts, Hongmei Luan, Deborah L. Knoerzer, Rita R. Gupta
Publikováno v:
Diabetes. 53:173-178
We aimed to test the hypothesis that the inducible form of nitric oxide synthase (iNOS) contributes to the development of an early subnormal retinal oxygenation response in preclinical models of diabetic retinopathy. In urethane anesthetized Sprague
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76d082d64dec1de5ea503c55ab98458
https://doi.org/10.2337/diabetes.53.1.173
https://doi.org/10.2337/diabetes.53.1.173
Autor:
Shin ichiro Kawai, Sucharita Das, Arthur H. Neufeld, Elizabeth Gachie, Smita C. Vora, Jane R Connor, Pamela T. Manning
Publikováno v:
Experimental Eye Research. 75:521-528
Following experimental, transient, retinal ischemia in the rat, there is loss of retinal neurons, which occurs over several weeks. Retinal ganglion cells (RGCs) are particularly susceptible and there is early, massive degeneration of these neurons af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cd6e8fa1ae48dc54e54cd4238c35ff
https://doi.org/10.1006/exer.2002.2042
https://doi.org/10.1006/exer.2002.2042
Autor:
Shin-ichiro Kawai, Jane R. Connor, Arthur H. Neufeld, Pamela T. Manning, Smita C. Vora, Elizabeth Gachie, Sucharita Das
Publikováno v:
Journal of Glaucoma. 11:221-225
To test the hypothesis that nitric oxide, synthesized by inducible nitric oxide synthase, causes degeneration of retinal ganglion cells in an animal model of glaucoma.Rats with unilateral, chronic, moderately elevated intraocular pressure were treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a24a41ff3b3f621f7110648775dc3ff
https://doi.org/10.1097/00061198-200206000-00010
https://doi.org/10.1097/00061198-200206000-00010
Autor:
Pamela T. Manning, Dragan V. Jovanovic, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mark G. Currie, Viorica Lascau-Coman, Jane R. Connor, Julio Cesar B. Fernandes
Publikováno v:
Arthritis & Rheumatism. 43:1290-1299
Objective To evaluate the in vivo therapeutic efficacy of N-iminoethyl-L-lysine (L-NIL), a selective inhibitor of inducible nitric oxide synthase, on the progression of structural lesions in the experimental canine model of osteoarthritis (OA), and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9114e0e4e64d16ecb6b87bbaed7671a6
https://doi.org/10.1002/1529-0131(200006)43:6<1290::aid-anr11>3.0.co
https://doi.org/10.1002/1529-0131(200006)43:6<1290::aid-anr11>3.0.co
Autor:
Albert E. Schmelzer, Mark G. Currie, Kam F. Fok, Pamela T. Manning, William M. Moore, Gina M. Jerome, Timothy J. Hagen, Arija A. Bergmanis, Barnett S. Pitzele, Linda F. Branson, Steven W. Kramer, E. Ann Hallinan, Christine Kornmeier, Lydia Swenton, Jane R. Connor
Publikováno v:
Journal of Medicinal Chemistry. 41:3675-3683
A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase (hiNOS) isoform versus the human endothelial nitric oxide synthase (heNOS) and the human neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b74f1de3e2f9933df0d68a6b9e2b8d4d
https://doi.org/10.1021/jm970840x
https://doi.org/10.1021/jm970840x
Autor:
Jean-Pierre Pelletier, Dragan V. Jovanovic, Mark G. Currie, Jane R. Connor, John A. Di Battista, Julio Cesar B. Fernandes, Johanne Martel-Pelletier, Pamela T. Manning
Publikováno v:
Arthritis & Rheumatism. 41:1275-1286
Objective To evaluate the in vivo therapeutic efficacy of N-iminoethyl-L-lysine (L-NIL), a selective inhibitor of inducible nitric oxide synthase (iNOS), on the progression of lesions in an experimental osteoarthritis (OA) dog model. The effect of L-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6600562b8f183d2a7074c09e9f2356b5
https://doi.org/10.1002/1529-0131(199807)41:7<1275::aid-art19>3.0.co
https://doi.org/10.1002/1529-0131(199807)41:7<1275::aid-art19>3.0.co
Autor:
Mark G. Currie, Karen B. Peterson, William M. Moore, Pamela T. Manning, Thomas P. Misko, Christine M. Kornmeier, Steven W. Kramer, Jane R. Connor, Gina M. Jerome, Barnett S. Pitzele, Mahima Trivedi, Foe S. Tjoeng, Donald W. Hansen, Ronald Keith Webber
Publikováno v:
Journal of Medicinal Chemistry. 41:1361-1366
An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681bd0252c2170629f7f44f4fd7f776a
https://doi.org/10.1021/jm9704715
https://doi.org/10.1021/jm9704715
Autor:
Suzanne Metz, Mahima Trivedi, William M. Moore, Timothy J. Hagen, Mark E. Zupec, Jane R. Connor, Mark G. Currie, B. S. Pitzele, Kam F. Fok, M. V. Toth, Pamela T. Manning, Ronald Keith Webber, D. W. Hansen, Gina M. Jerome, F. S. Tjoeng
Publikováno v:
Journal of Medicinal Chemistry. 41:96-101
A series of analogues of 2-iminopiperidine have been prepared and shown to be potent inhibitors of the human nitric oxide synthase (NOS) isoforms. Methyl substitutions on the 4-position (3) or 4- and 6-positions (8) afforded the most potent analogues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb0f40a0d108843036268d55d4ebec4b
https://doi.org/10.1021/jm9705059
https://doi.org/10.1021/jm9705059
Publikováno v:
Current Pharmaceutical Design. 3:447-462
Abstract: Nitric oxide is synthesized enzymatically from arginine in numerous tissues and cell types by three_distinct isoforms of the enzyme nitric oxide synthase (NOS). Two of these isoforms are expressed in a constitutive manner (cNOS) predominant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41990ebd1f15266097d00d6dbea2dbdc
https://doi.org/10.2174/138161280305221010094339
https://doi.org/10.2174/138161280305221010094339
Autor:
and Foe S. Tjoeng, Mark G. Currie, Kam F. Fok, R. Keith Webber, William M. Moore, Pamela T. Manning, Jane R. Connor, Pamela S. Wyatt, Thomas P. Misko, Gina M. Jerome
Publikováno v:
Journal of Medicinal Chemistry. 39:669-672
A series of 2-iminoazaheterocycles have been prepared and shown to be potent inhibitors of human nitric oxide synthase (NOS) isoforms. This series includes cyclic amidines ranging from five- to nine-membered rings, of which 2-iminopiperidine and 2-im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c3d2fbf2c456f6ca464352f4f27607
https://doi.org/10.1021/jm950766n
https://doi.org/10.1021/jm950766n