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Akademický článek

Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent.

Autor: Jane Q Chen, Hidetoshi Mori, Robert D Cardiff, Josephine F Trott, Russell C Hovey, Neil E Hubbard, Jesse A Engelberg, Clifford G Tepper, Brandon J Willis, Imran H Khan, Resmi K Ravindran, Szeman R Chan, Robert D Schreiber, Alexander D Borowsky

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129895 (2015)

Female 129:Stat1-null mice (129S6/SvEvTac-Stat1(tm1Rds) homozygous) uniquely develop estrogen-receptor (ER)-positive mammary tumors. Herein we report that the mammary glands (MG) of these mice have altered growth and development with abnormal termina

Externí odkaz: https://doaj.org/article/29929a32a62840c7829521206f08d497

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Akademický článek

Pathobiology of the 129:Stat1 −/− mouse model of human age-related ER-positive breast cancer with an immune infiltrate-excluded phenotype

Autor: Hidetoshi Mori, Jane Q. Chen, Robert D. Cardiff, Zsófia Pénzváltó, Neil E. Hubbard, Louis Schuetter, Russell C. Hovey, Josephine F. Trott, Alexander D. Borowsky

Publikováno v: Breast Cancer Research, Vol 19, Iss 1, Pp 1-18 (2017)

Abstract Background Stat1 gene-targeted knockout mice (129S6/SvEvTac-Stat1 tm1Rds) develop estrogen receptor-positive (ER+), luminal-type mammary carcinomas at an advanced age. There is evidence for both host environment as well as tumor cell-intrins

Externí odkaz: https://doaj.org/article/45215435b0f24753a764f145235b39fa

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