Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jane P. Hughes"'
Autor:
Lasse Stach, Emily K. H. Dinley, Nadia Tournier, Ryan P. Bingham, Darren A. Gormley, Jo L. Bramhall, Adam Taylor, Jane E. Clarkson, Katherine A. Welbeck, Claire L. Harris, Maria Feeney, Jane P. Hughes, Armin Sepp, Thil D. Batuwangala, Semra J. Kitchen, Eva-Maria Nichols
Publikováno v:
Antibodies, Vol 10, Iss 4, p 39 (2021)
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Externí odkaz:
https://doaj.org/article/9c08d3afb4f34afc913b99f6d81d4c48
Autor:
Anna K Dreismann, Thomas M Hallam, Lawrence CS Tam, Calvin V Nguyen, Jane P Hughes, Scott Ellis, Claire L Harris
Publikováno v:
Immunological Reviews. 313:402-419
The complement alternative pathway (AP) is implicated in numerous diseases affecting many organs, ranging from the rare hematological disease paroxysmal nocturnal hemoglobinuria (PNH), to the common blinding disease age-related macular degeneration (
Autor:
Christina Levick, Jane Phillips-Hughes, Jane Collier, Rajarshi Banerjee, Jeremy F Cobbold, Lai Mun Wang, Stefan K Piechnik, Matthew D Robson, Stefan Neubauer, Eleanor Barnes, Michael Pavlides
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221066 (2019)
Background and aimsNon-invasive assessment of portal hypertension is an area of unmet need. This proof of concept study aimed to evaluate the diagnostic accuracy of a multi-parametric magnetic resonance technique in the assessment of portal hypertens
Externí odkaz:
https://doaj.org/article/23463355f9f44d36a82d13ac663f5d45
Autor:
Jane E Clarkson, Nadia Tournier, Ryan P. Bingham, Maria Feeney, Semra Kitchen, Jo L Bramhall, Darren A. Gormley, Lasse Stach, Eva-Maria Nichols, Jane P. Hughes, Katherine A Welbeck, Claire L. Harris, Adam Taylor, Armin Sepp, Thil D. Batuwangala, Emily K H Dinley
Publikováno v:
Antibodies, Vol 10, Iss 39, p 39 (2021)
Antibodies
Volume 10
Issue 4
Antibodies
Volume 10
Issue 4
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Autor:
Jane M Hughes, Daniel J Schmidt, Joel A Huey, Kathryn M Real, Thomas Espinoza, Andrew McDougall, Peter K Kind, Steven Brooks, David T Roberts
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0121858 (2015)
The Australian lungfish is a unique living representative of an ancient dipnoan lineage, listed as 'vulnerable' to extinction under Australia's Environment Protection and Biodiversity Conservation Act 1999. Historical accounts indicate this species o
Externí odkaz:
https://doaj.org/article/d83c35c9024445e4b18f1519a4189aae
Autor:
Charlotte R. Hurry, Daniel J. Schmidt, Mark Ponniah, Giovannella Carini, David Blair, Jane M. Hughes
Publikováno v:
PeerJ, Vol 2, p e552 (2014)
Comparative phylogeography of commensal species may show congruent patterns where the species involved share a common history. Temnosewellia is a genus of flatworms, members of which live in commensal relationships with host freshwater crustaceans. B
Externí odkaz:
https://doaj.org/article/ca8fd73c383d4879bc93954ee925a095
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63375 (2013)
Knowledge about the biogeography of organisms has long been a focus in ecological research, including the mechanisms that generate and maintain diversity. In this study, we targeted a microbial group relatively underrepresented in the microbial bioge
Externí odkaz:
https://doaj.org/article/8cf46af2384749ada88373884cc5c5f8
Autor:
Jane P. Hughes, Praveen Anand, Saba Alzabin, Richard O. Williams, Marc Feldmann, Julia J. Inglis, Kay McNamee
Interleukin-17 (IL-17) and tumour necrosis factor-α (TNF) are critical in the pathogenesis of arthritis but their relationship during inflammatory pain has received limited attention. We aimed to establish whether IL-17 can induce hyperalgesia in ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d3082e6061d0557104d5a8a647da8a
https://doi.org/10.1016/j.pain.2011.03.035
https://doi.org/10.1016/j.pain.2011.03.035
Publikováno v:
Neurochemical Research. 35:588-597
Apoptosis-associated tyrosine kinase (AATYK) is up-regulated by phosphorylation in cultured cerebellar granule neurons (CGN) undergoing apoptosis upon switch to low KCl-containing medium. However, the underlying signaling pathways remain to be fully
Autor:
Jane P. Hughes, Lauriane Ulmann, François Rassendren, Severine Chaumont, Alison J Reeve, Paula J. Green, Jon P. Hatcher, Iain P. Chessell, G. Buell, François Conquet
Publikováno v:
The Journal of Neuroscience. 28:11263-11268
ATP is a known mediator of inflammatory and neuropathic pain. However, the mechanisms by which specific purinergic receptors contribute to chronic pain states are still poorly characterized. Here, we demonstrate that in response to peripheral nerve i