Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jane McKeating"'
Autor:
Jonathan M. Hazlehurst, Teegan Reina Lim, Catriona Charlton, Jack J. Miller, Laura L. Gathercole, Thomas Cornfield, Nikolaos Nikolaou, Shelley E. Harris, Ahmad Moolla, Nantia Othonos, Lisa C. Heather, Thomas Marjot, Damian J. Tyler, Carolyn Carr, Leanne Hodson, Jane McKeating, Jeremy W. Tomlinson
Publikováno v:
Metabolism Open, Vol 14, Iss , Pp 100177- (2022)
Background and aims: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver condition. It is tightly associated with an adverse metabolic phenotype (including obesity and type 2 diabetes) as well as with obstructive sleep apnoea (
Externí odkaz:
https://doaj.org/article/4594b0aa997b40519a78b4393c21a3ac
Autor:
Kwan-Ki Hwang, Ashley M Trama, Daniel M Kozink, Xi Chen, Kevin Wiehe, Abby J Cooper, Shi-Mao Xia, Minyue Wang, Dawn J Marshall, John Whitesides, Munir Alam, Georgia D Tomaras, Steven L Allen, Kanti R Rai, Jane McKeating, Rosa Catera, Xiao-Jie Yan, Charles C Chu, Garnett Kelsoe, Hua-Xin Liao, Nicholas Chiorazzi, Barton F Haynes
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90725 (2014)
B-cell chronic lymphocytic leukemia (B-CLL) patients expressing unmutated immunoglobulin heavy variable regions (IGHVs) use the IGHV1-69 B cell receptor (BCR) in 25% of cases. Since HIV-1 envelope gp41 antibodies also frequently use IGHV1-69 gene seg
Externí odkaz:
https://doaj.org/article/ca7014c87aff4e82ac23ca58b421f885
Autor:
Tao Dong, Guihai Liu, Suet Felce, Xuan Yao, Zixi Yin, Anastasia Fries, Alexander Mentzer, Danning Dong, Wenbo Wang, Wanwisa Dejnirattisai, Piyada Supasa, Chang Liu, Peter Wing, Timothy Rostron, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Philip Hublitz, Ryan Beveridge, Jeremy Fry, Jane McKeating, Juthathip Mongkolsapaya, Gavin Screaton, Graham Ogg, Julian Knight, Yanchun Peng
Little is known of the role of cytotoxic CD4+ T-cells in the control of viral replication. Here, we investigate CD4+ T-cell responses to three dominant SARS-CoV-2 epitopes and evaluate antiviral activity, including cytotoxicity and antiviral cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6d7b664e3d46e6705f28f1fe1dab4d
https://doi.org/10.21203/rs.3.rs-1317569/v1
https://doi.org/10.21203/rs.3.rs-1317569/v1
Publikováno v:
Journal of Hepatology. 77:267-268
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fadba22a558f0b756e2b653c5a305493
https://doi.org/10.1016/j.jhep.2022.03.027
https://doi.org/10.1016/j.jhep.2022.03.027
Publikováno v:
Seminars in immunopathology. 44(2)
The daily oscillations of bi ological and behavioural processes are controlled by the circadian clock circuitry that drives the physiology of the organism and, in particular, the functioning of the immune system in response to infectious agents. Circ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7bf18de4d172649eedd7584e7c22bb
https://pubmed.ncbi.nlm.nih.gov/35192001
https://pubmed.ncbi.nlm.nih.gov/35192001
Autor:
Tao Dong, Graham Ogg, Yan-Chun Peng, Suet Felce, Danning Dong, Frank Penkava, Alexander Mentzer, Xuan Lao, Guihai Liu, Zixi Yin, Ji-Li Chen, YongXu Lu, Dannielle Wellington, Peter Wing, Delaney Dominey-Foy, Julian Knight, Chen Jin, Wenbo Wang, Megat Abd Hamid, Ricardo Fernandes, Beibei Wang, Anastasia Fries, Xiaodong Zhuang, Neil Ashley, Timothy Rostron, Craig Waugh, Paul Sopp, Philip Hublitz, Ryan Beveridge, Tiong Kit Tan, Christina Dold, Andrew Kwok, Charlotte Rich-Griffin, Wanwisa Dejnirattisai, Isar Nassiri, Robert Watson, Orion Tong, Chelsea Taylor, Piyush Kumar Sharma, Fabiola Curion, Santiago Revale, Lucy Garner, Kathrin Jansen, Ricardo Ferreira, Moustafa Attar, Jeremy Fry, Rebecca Russell, Hans Stauss, William James, Alain Townsend, Ling-Pei Ho, Juthathip Mongkolsapaya, Paul Klenerman, Gavin Screaton, Calliope Dendrou, Stephen Sansom, Rachael Bashford-Rogers, Benny Chain, Geoffrey Smith, Jane McKeating, Benjamin Fairfax, Paul Bowness, Andrew McMichael
NP105-113-B*07:02 specific CD8+ T-cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP105-113-B*07:02 specific T-cell clones and singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167f2ea271cbc55149a70fe16ddbea87
https://doi.org/10.21203/rs.3.rs-734011/v1
https://doi.org/10.21203/rs.3.rs-734011/v1
Autor:
Atish Mukherji, Frank Jühling, Laurent Mailly, Carla Eller, Katharina Herzog, Cloé Gadenne, Clara Ponsolles, Alexandre Haller, Philippe Baltzinger, Hiroshi Aikata, Michio Imamura, Catherine Schuster, Xiaodong Zhuang, Jacinta Holmes, Jane McKeating, Irwin Davidson, Patrick Pessaux, Joachim Lupberger, Thomas Baumert
Publikováno v:
Journal of Hepatology. 77:S758
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8eb53674e41285704cd4b90cd6d06be
https://doi.org/10.1016/s0168-8278(22)01831-1
https://doi.org/10.1016/s0168-8278(22)01831-1
Autor:
Isabelle Desombere, Freya Van Houtte, Ali Farhoudi, Lieven Verhoye, Caroline Buysschaert, Yvonne Gijbels, Sibyl Couvent, Wilfried Swinnen, Hans Van Vlierberghe, André Elewaut, Zania Stamataki, Philip Meuleman, Jane McKeating, Geert Leroux-Roels
Hepatitis C virus (HCV) is highly variable and transmits through infected blood to establish a chronic liver infection in the majority of patients. Our knowledge of the infectivity of clinical HCV strains is hampered by the lack of in vitro cell cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fbea4572a0f073a44803411c876c221
https://doi.org/10.21203/rs.3.rs-41273/v1
https://doi.org/10.21203/rs.3.rs-41273/v1
Autor:
Christopher G. Fawsitt, Peter Vickerman, Graham S. Cooke, Nicky J. Welton, Eleanor Barnes, Jonathan Ball, Diana Brainard, Gary Burgess, John Dillon, Graham Foster, Charles Gore, Neil Guha, Rachel Halford, Kevin Whitby, Chris Holmes, Anita Howe, Emma Hudson, Sharon Hutchinson, William Irving, Salim Khakoo, Paul Klenerman, Natasha Martin, Benedetta Massetto, Tamyo Mbisa, John McHutchison, Jane McKeating, John McLauchlan, Alec Miners, Andrea Murray, Peter Shaw, Peter Simmonds, Chris Spencer, Emma Thomson, Nicole Zitzmann
Publikováno v:
Fawsitt, C G, Vickerman, P, Cooke, G S & Welton, N J 2020, ' Cost-Effectiveness Analysis of Baseline Testing for Resistance-Associated Polymorphisms to Optimize Treatment Outcome in Genotype 1 Noncirrhotic Treatment-Naïve Patients With Chronic Hepatitis C Virus ', Value in Health, vol. 23, no. 2, pp. 180-190 . https://doi.org/10.1016/j.jval.2019.08.012
Value in Health
Value in Health
Objectives Direct-acting antivirals containing nonstructural protein 5A (NS5A) inhibitors administered over 8 to 12 weeks are effective in ∼95% of patients with hepatitis C virus. Nevertheless, patients resistant to NS5A inhibitors have lower cure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c75b841cd2d913392eb0a841339c92b7
https://research-information.bris.ac.uk/en/publications/d4089c71-044d-413d-a696-78cab971d9ab
https://research-information.bris.ac.uk/en/publications/d4089c71-044d-413d-a696-78cab971d9ab
Autor:
Christopher G. Fawsitt, Peter Vickerman, Graham Cooke, Nicky J. Welton, Eleanor Barnes, Jonathan Ball, Diana Brainard, Gary Burgess, John Dillon, Graham Foster, Charles Gore, Neil Guha, Rachel Halford, Kevin Whitby, Chris Holmes, Anita Howe, Emma Hudson, Sharon Hutchinson, William Irving, Salim Khakoo, Paul Klenerman, Natasha Martin, Benedetta Massetto, Tamyo Mbisa, John McHutchison, Jane McKeating, John McLauchlan, Alec Miners, Andrea Murray, Peter Shaw, Peter Simmonds, Chris Spencer, Emma Thomson, Nicole Zitzmann
Publikováno v:
Fawsitt, C, Vickerman, P, Cooke, G S, Welton, N 2019, ' A Cost-Effectiveness Analysis of Shortened Direct-Acting Antiviral Treatment in Genotype 1 Noncirrhotic Treatment-Naive Patients With Chronic Hepatitis C Virus ', Value in Health, vol. 22, no. 6, pp. 693-703 . https://doi.org/10.1016/j.jval.2018.12.011
Value in Health
Value in Health
Background Direct-acting antivirals are successful in curing hepatitis C virus infection in more than 95% of patients treated for 12 weeks, but they are expensive. Shortened treatment durations, which may have lower cure rates, have been proposed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df5397df467fd01dfa38c012bd05c96
https://research-information.bris.ac.uk/en/publications/b8fa8f31-6b83-4348-bdd7-9a454a65cb43
https://research-information.bris.ac.uk/en/publications/b8fa8f31-6b83-4348-bdd7-9a454a65cb43