Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Jane M. Vanderkooi"'
Autor:
Carol Buettger, Pan Chen, Jane M. Vanderkooi, Ramakanth Sarabu, Bogumil Zelent, Monique Laberge, Joseph Grimsby, Franz M. Matschinsky, Stella Odili, Dorothy Zelent, Joseph Bass, Deborah Fenner, Charles A. Stanley
Publikováno v:
Biochemical Journal. 440:203-215
GK (glucokinase) is activated by glucose binding to its substrate site, is inhibited by GKRP (GK regulatory protein) and stimulated by GKAs (GK activator drugs). To explore further the mechanisms of these processes we studied pure recombinant human G
Autor:
Jane M. Vanderkooi, J. Nathan Scott
Publikováno v:
Applied Spectroscopy. 65:756-764
The effect of high pressure on the OH stretch of dilute HOD in D(2)O was examined using high-pressure Fourier transform infrared (FT-IR) spectroscopy. It was found that at pressures directly above the ice VI to ice VII transition, ice VII displays a
Autor:
Nicolai M. Doliba, Franz M. Matschinsky, Ramakanth Sarabu, Jane M. Vanderkooi, Ali Naji, Joseph Grimsby, Changhong Li, Bogumil Zelent
Publikováno v:
Diabetes Care
Type 2 diabetes is characterized by elevated blood glucose levels resulting from a pancreatic β-cell secretory insufficiency combined with insulin resistance, most significantly manifested in skeletal muscle and liver (1). If untreated, diabetic com
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1804:1508-1515
The stability of bovine lactoperoxidase to denaturation by guanidinium-HCl, urea, or high temperature was examined by differential scanning calorimetry (DSC) and tryptophan fluorescence. The calorimetric scans were observed to be dependent on the hea
Autor:
Kim A. Sharp, Jane M. Vanderkooi
Publikováno v:
Accounts of Chemical Research. 43:231-239
Water is a highly polar molecule, consisting of a very electronegative atom, oxygen, bonded to two weakly electropositive hydrogen atoms with two lone pairs of electrons. These features give water remarkable physical properties, some of which are ano
Autor:
Jane M. Vanderkooi, Brad L. Pentelute, Stephen B. H. Kent, Jennifer L. Dashnau, Zachary P. Gates
Publikováno v:
Journal of the American Chemical Society. 130:9702-9707
The recently discovered glycine-rich snow flea antifreeze protein (sfAFP) has no sequence homology with any known proteins. No experimental structure has been reported for this interesting protein molecule. Here we report the total chemical synthesis
Autor:
Valentina Tereshko, Stephen B. H. Kent, Jane M. Vanderkooi, Brad L. Pentelute, Anthony A. Kossiakoff, Jennifer L. Dashnau, Zachary P. Gates
Publikováno v:
Journal of the American Chemical Society. 130:9695-9701
Chemical protein synthesis and racemic protein crystallization were used to determine the X-ray structure of the snow flea antifreeze protein (sfAFP). Crystal formation from a racemic solution containing equal amounts of the chemically synthesized pr
Publikováno v:
The Journal of Physical Chemistry B. 112:4022-4035
In this study, we examine the coupling of a complex ring vibration to solvent through hydrogen-bonding interactions. We compare phenylalanine, tyrosine, l-dopa, dopamine, norepinephrine, epinephrine, and hydroxyl-dl-dopa, a group of physiologically i
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1780:41-50
The OH stretch mode from water and organic hydroxyl groups have strong infrared absorption, the position of the band going to lower frequency with increased H-bonding. This band was used to study water in trehalose and glycerol solutions and in genet
Publikováno v:
Photochemistry and Photobiology. 80:36-40
The heme in horseradish peroxidase (HRP) was replaced by phosphorescent Pt-mesoporphyrin IX (PtMP), which acted as a phosphorescent marker of oxygen quenching and allowed comparison with another probe, Pd-mesoporphyrin IX (Khajehpour et al. (2003) Pr