Zobrazeno 1 - 10
of 551
pro vyhledávání: '"Jane M. Blazeby"'
Autor:
Lucy J. Goudswaard, Madeleine L. Smith, David A. Hughes, Roy Taylor, Michael Lean, Naveed Sattar, Paul Welsh, Alex McConnachie, Jane M. Blazeby, Chris A. Rogers, Karsten Suhre, Shaza B. Zaghlool, Ingeborg Hers, Nicholas J. Timpson, Laura J. Corbin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with adiposity. We aimed to identify consistent protein
Externí odkaz:
https://doaj.org/article/e953ad6528d543d2aff46ecd47dd08c1
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-6 (2023)
Abstract The use of invasive placebo controls in surgical trials can be challenging. The ASPIRE guidance, published in the Lancet in 2020, provided advice for the design and conduct of surgical trials with an invasive placebo control. Based on a more
Externí odkaz:
https://doaj.org/article/581d9c547c924c36a1f4152dd79de746
Autor:
Karen D. Coulman, Ruta Margelyte, Tim Jones, Jane M. Blazeby, John Macleod, Amanda Owen-Smith, Helen Parretti, Richard Welbourn, Maria Theresa Redaniel, Andy Judge
Publikováno v:
PLoS Medicine, Vol 20, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/06cf6386107b479494c6e3ad164aaaec
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-8 (2022)
Abstract Background The complexities associated with delivering randomised surgical trials, such as clustering effects, by centre or surgeon, and surgical learning, are well known. Despite this, approaches used to manage these complexities, and opini
Externí odkaz:
https://doaj.org/article/d497eba3f4f0413ca22aea790ab52920
Autor:
Jenny L. Donovan, Marcus Jepson, Leila Rooshenas, Sangeetha Paramasivan, Nicola Mills, Daisy Elliott, Julia Wade, Domenic Reda, Jane M. Blazeby, Drew Moghanaki, E. Shelley Hwang, Louise Davies
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Many randomised controlled trials (RCTs) struggle to recruit, despite valiant efforts. The QRI (QuinteT Recruitment Intervention) uses innovative research methods to optimise recruitment by revealing previously hidden barriers rel
Externí odkaz:
https://doaj.org/article/8ead252c2c08440097d981bf538be64e
Autor:
Bilal Alkhaffaf, Jane M. Blazeby, Aleksandra Metryka, Anne-Marie Glenny, Ademola Adeyeye, Paulo Matos Costa, Ismael Diez del Val, Suzanne S. Gisbertz, Ali Guner, Simon Law, Hyuk-Joon Lee, Ziyu Li, Koji Nakada, Rafael Mauricio Restrepo Nuñez, Daniel Reim, John V. Reynolds, Peter Vorwald, Daniela Zanotti, William Allum, M. Asif Chaudry, Ewen Griffiths, Paula R. Williamson, Iain A. Bruce, on behalf of the GASTROS International Working Group
Publikováno v:
Trials, Vol 22, Iss 1, Pp 1-17 (2021)
Abstract Background Core outcome sets (COS) should be relevant to key stakeholders and widely applicable and usable. Ideally, they are developed for international use to allow optimal data synthesis from trials. Electronic Delphi surveys are commonly
Externí odkaz:
https://doaj.org/article/b07c23c4ef904e0a8ba0367cc5024d73
Publikováno v:
BMC Medical Research Methodology, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Typically, subgroup analyses in clinical trials are conducted by comparing the intervention effect in each subgroup by means of an interaction test. However, trials are rarely, if ever, adequately powered for interaction tests, so
Externí odkaz:
https://doaj.org/article/fcc7536b816849b7a6852e77ccb31368
Autor:
Samantha Husbands, Daisy Elliott, Tim R. C. Davis, Jane M. Blazeby, Eleanor F. Harrison, Alan A. Montgomery, Kirsty Sprange, Lelia Duley, Alexia Karantana, William Hollingworth, Nicola Mills
Publikováno v:
Pilot and Feasibility Studies, Vol 6, Iss 1, Pp 1-11 (2020)
Abstract Background Recruitment to randomised controlled trials (RCTs) can be challenging, with most trials not reaching recruitment targets. Randomised feasibility studies can be set up prior to a main trial to identify and overcome recruitment obst
Externí odkaz:
https://doaj.org/article/ab4400ff59734fc89a704a749dd56b99
Autor:
Gareth Davies, Daniel Yeomans, Zoe Tolkien, Irene A. Kreis, Shelley Potter, Matthew D. Gardiner, Abhilash Jain, James Henderson, Jane M. Blazeby
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Patient adherence to treatment is a key determinant of outcome for healthcare interventions. Whilst non-adherence has been well evidenced in settings such as drug therapy, information regarding patient adherence to orthoses, parti
Externí odkaz:
https://doaj.org/article/d001b1b7cd714a06a0bbc2dbc3f4ce9a
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Patient outcomes can depend on the treating centre, or health professional, delivering the intervention. A health professional’s skill in delivery improves with experience, meaning that outcomes may be associated with learning.
Externí odkaz:
https://doaj.org/article/d23a09064673439192a3ec177fa1c5df