Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jane Levesley"'
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64051 (2013)
Pediatric high grade glioma is refractory to conventional multimodal treatment, highlighting a need to develop novel efficacious therapies. We investigated tumor metabolism as a potential therapeutic target in a panel of diverse pediatric glioma cell
Externí odkaz:
https://doaj.org/article/35cb4bf5aa484e7e9458b0e97517e932
Autor:
Richard G. Grundy, Beth Coyle, Chris O'Callaghan, Andrew Peet, Siobhan Quinn, John-Paul Kilday, Jane Levesley, Robert A. Hirst, Teresa Osteso-Ibanez, Ruman Rahman
Supplementary Figure 2 from Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc51fea15efb6ebc23cf70cce5817b5c
https://doi.org/10.1158/1535-7163.22485576.v1
https://doi.org/10.1158/1535-7163.22485576.v1
Autor:
Richard G. Grundy, Beth Coyle, Chris O'Callaghan, Andrew Peet, Siobhan Quinn, John-Paul Kilday, Jane Levesley, Robert A. Hirst, Teresa Osteso-Ibanez, Ruman Rahman
Supplementary Figure 1 from Histone Deacetylase Inhibition Attenuates Cell Growth with Associated Telomerase Inhibition in High-Grade Childhood Brain Tumor Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0323f4cb9fdd1cdfa6f59e73f1f7a09a
https://doi.org/10.1158/1535-7163.22485579
https://doi.org/10.1158/1535-7163.22485579
Autor:
Richard G. Grundy, Beth Coyle, Chris O'Callaghan, Andrew Peet, Siobhan Quinn, John-Paul Kilday, Jane Levesley, Robert A. Hirst, Teresa Osteso-Ibanez, Ruman Rahman
Aberrant epigenetic regulation of gene expression contributes to tumor initiation and progression. Studies from a plethora of hematologic and solid tumors support the use of histone deacetylase inhibitors (HDACi) as potent anticancer agents. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe1d5d2975f3787e00926b46ec87e2c
https://doi.org/10.1158/1535-7163.c.6532005
https://doi.org/10.1158/1535-7163.c.6532005
Autor:
Chunyong Ding, Anke Brüning-Richardson, Sean E. Lawler, Susan C Short, Jane Levesley, Jia Zhou, Adam Davison, Lynette Steele
Publikováno v:
Neuro-Oncology. 20:203-214
Background CNS tumors, including medulloblastoma and pediatric glioblastoma (pGBM) account for the majority of solid pediatric malignancies. There remains an unmet need to identify novel treatment approaches in poor prognosis and relapsed pediatric b
Autor:
Susan Picton, Elizabeth Ilett, Julia V. Cockle, Jane Levesley, L P Steel, Anke Brüning-Richardson, A M Carcaboso, Sean E. Lawler, Alan Melcher, Susan C Short
Publikováno v:
British Journal of Cancer
BRITISH JOURNAL OF CANCER
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
BRITISH JOURNAL OF CANCER
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Background: Paediatric high grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) are highly aggressive brain tumours. Their invasive phenotype contributes to their limited therapeutic response, and novel treatments that block brain tumour
Autor:
Anke Brüning-Richardson, Jia Zhou, Jane Levesley, Sean E. Lawler, Adam Davison, Lynette Steele, Susan C Short
Publikováno v:
Neuro-Oncology. 19:iii94-iii94
BACKGROUND: Small molecule inhibitors of the mitotic kinases, including the Aurora kinase inhibitor MLN8237, are being investigated as novel therapeutic agents for the treatment of solid cancers including malignant brain tumours. However, resistance
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64051 (2013)
PLoS ONE
PLoS ONE
Pediatric high grade glioma is refractory to conventional multimodal treatment, highlighting a need to develop novel efficacious therapies. We investigated tumor metabolism as a potential therapeutic target in a panel of diverse pediatric glioma cell
Autor:
Beth Coyle, Richard Grundy, Janet C. Lindsey, Steven C. Clifford, Jane Levesley, Meryl E. Lusher
Publikováno v:
Neuro-oncology. 13(12)
The RASSF1A tumor suppressor is potentially the most important candidate gene identified in medulloblastoma to date, being epigenetically silenced in >79% of primary tumors. However, its functional role has not been previously addressed in this tumor
Autor:
John-Paul Kilday, Siobhan Quinn, Christopher O'Callaghan, Andrew C. Peet, Beth Coyle, Jane Levesley, Robert A. Hirst, Teresa Osteso-Ibanez, Ruman Rahman, Richard Grundy
Publikováno v:
Molecular cancer therapeutics. 9(9)
Aberrant epigenetic regulation of gene expression contributes to tumor initiation and progression. Studies from a plethora of hematologic and solid tumors support the use of histone deacetylase inhibitors (HDACi) as potent anticancer agents. However,