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Akademický článek

Cognitive function and treatment response trajectories in first-episode schizophrenia: evidence from a prospective cohort study

Publikováno v: BMJ Open, Vol 12, Iss 11 (2022)

Objectives This prospective cohort study tested for associations between baseline cognitive performance in individuals early within their first episode and antipsychotic treatment of psychosis. We hypothesised that poorer cognitive functioning at the

Externí odkaz: https://doaj.org/article/24b84b4f0e3248a4be25b8fa5a018358

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Akademický článek

Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study

Autor: Robin M Murray, Richard Drake, Stephen Lawrie, Laura Kassoumeri, James Walters, Shon Lewis, Anna Murphy, James MacCabe, Oliver D Howes, Edward Millgate, Eugenia Kravariti, Alice Egerton, Jacek Donocik, Tracy Collier, Jane Lees, Charlotte Stockton-Powdrell, Bill Deakin

Publikováno v: BMJ Open, Vol 11, Iss 11 (2021)

Background 70%–84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizoph

Externí odkaz: https://doaj.org/article/5c29a747d3fb491da3842a8728ebc56a

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Anterior cingulate glutamate metabolites as a predictor of antipsychotic response in first episode psychosis: data from the STRATA collaboration

Autor: Alice Egerton, Kira Griffiths, Cecila Casetta, John Deakin, Richard Drake, Oliver Howes, Laura Kassoumeri, Sobia Khan, Steve Lankshear, Jane Lees, Shôn Lewis, Elena Mikulskaya, Edward Millgate, Ebenezer Oloyede, Rebecca Pollard, Nathalie Rich, Aviv Segev, Kyra-Verena Sendt, James MacCabe

Publikováno v: Neuropsychopharmacology. 48:567-575

Elevated brain glutamate has been implicated in non-response to antipsychotic medication in schizophrenia. Biomarkers that can accurately predict antipsychotic non-response from the first episode of psychosis (FEP) could allow stratification of patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c98f5d4dd667a2773887307500ab27
https://doi.org/10.1038/s41386-022-01508-w

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Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study

Autor: Tracy Collier, Bill Deakin, Charlotte Stockton-Powdrell, Robin M. Murray, James H. MacCabe, Jane Lees, Alice Egerton, Richard Drake, Edward Millgate, Jacek Donocik, Shôn Lewis, James T.R. Walters, Oliver D. Howes, Eugenia Kravariti, Anna Murphy, Stephen M. Lawrie, Laura Kassoumeri

Publikováno v: BMJ Open
King's College London
Millgate, E, Kravariti, E, Egerton, A, Howes, O D, Murray, R M, Kassoumeri, L, Donocik, J, Lewis, S, Drake, R, Lawrie, S, Murphy, A, Collier, T, Lees, J, Stockton-powdrell, C, Walters, J, Deakin, B & Maccabe, J 2021, ' Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study ', BMJ Open, vol. 11, no. 11, pp. e054160 . https://doi.org/10.1136/bmjopen-2021-054160
BMJ Open, Vol 11, Iss 11 (2021)

Background70%–84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizophr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3c1426ea7df6a50b2919cd2989a3df
https://pubmed.ncbi.nlm.nih.gov/34824121

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Uptake of internet-delivered UK adult hearing assessment

Autor: Harvey Dillon, Timothy L Frank, Jane Lees, Christopher J. Armitage, Kevin J. Munro, David R. Moore, Antonia Marsden, Piers Dawes

Publikováno v: Dawes, P, Munro, K J, Frank, T L, Moore, D R, Armitage, C, Marsden, A, Lees, J & Dillon, H 2021, ' Uptake of internet-delivered UK adult hearing assessment ', International Journal of Audiology, pp. 1-5 . https://doi.org/10.1080/14992027.2021.1886353

OBJECTIVE: To evaluate uptake of the internet-based hearing test, with respect to the 11% of UK adults that have hearing loss but do not use hearing aids.DESIGN: Feasibility study in a primary care practice in the North of England.STUDY SAMPLE: Adult

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5851dde539176df0504e74e5efe60bbc
https://pubmed.ncbi.nlm.nih.gov/33820477

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Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis::A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA)

Publikováno v: Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G, Collier, T, Deakin, B, Drake, R, Eliasson, E, Emsley, R, Gregory, C, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Emily, L, Lawrie, S, Lees, J, Lewis, S W, Lythgoe, D, Matthews, J C, McGuire, P, Lily, M, Semple, S, Shaw, A, Singh, K, Stockton-Powdrell, C, Talbot, P S, Veronese, M, Wagner, E, Walters, J, Williams, S, Maccabe, J & Howes, O 2020, ' Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis: A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA). ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sbaa128
Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G J, Collier, T, Deakin, B, Drake, R, Eliasson, E, Emsley, R, Gregory, C J, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Lambe, E J B, Lawrie, S M, Lees, J, Lewis, S, Lythgoe, D J, Matthews, J, McGuire, P, McNamee, L, Semple, S, Shaw, A D, Singh, K D, Stockton-Powdrell, C, Talbot, P S, Veronese, M, Wagner, E, Walters, J T R, Williams, S R, Maccabe, J H & Howes, O D 2021, ' Dopamine and Glutamate in Antipsychotic-Responsive Compared with Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) ', Schizophrenia Bulletin, vol. 47, no. 2, pp. 505-516 . https://doi.org/10.1093/schbul/sbaa128
Schizophrenia Bulletin
Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G J, Collier, T, Deakin, J F W, Drake, R, Eliasson, E, Emsley, R, Gregory, C, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Lambe, E J B, Lawrie, S M, Lees, J, Lewis, S, Lythgoe, D J, Matthews, J, McGuire, P K, McNamee, L, Semple, S I, Shaw, A D, Singh, K D, Stockton-Powdrell, C, Talbot, P, Veronese, M, Wagner, E, Walters, J T R, Williams, S R, MacCabe, J H & Howes, O D 2020, ' Dopamine and Glutamate in Antipsychotic-Responsive compared to Antipsychotic Non-Responsive Psychosis : A Multicentre Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sbaa128
Egerton, A, Murphy, A, Donocik, J, Anton, A, Barker, G J, Collier, T, Deakin, B, Drake, R, Eliasson, E, Emsley, R, Gregory, C J, Griffiths, K, Kapur, S, Kassoumeri, L, Knight, L, Lambe, E J B, Lawrie, S M, Lees, J, Lewis, S, Lythgoe, D J, Matthews, J, Mcguire, P, Mcnamee, L, Semple, S, Shaw, A D, Singh, K D, Stockton-powdrell, C, Talbot, P S, Veronese, M, Wagner, E, Walters, J T R, Williams, S R, Maccabe, J H & Howes, O D 2020, ' Dopamine and Glutamate in Antipsychotic-Responsive Compared With Antipsychotic-Nonresponsive Psychosis: A Multicenter Positron Emission Tomography and Magnetic Resonance Spectroscopy Study (STRATA) ', Schizophrenia Bulletin . https://doi.org/10.1093/schbul/sbaa128

The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f942b5e7c2d3d85aa3500f679c45dc
https://kclpure.kcl.ac.uk/en/publications/9ca2ff41-86da-43f6-80e9-532395817b4c

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A longitudinal comparison of two neurocognitive test batteries in patients with schizophrenia and healthy volunteers: Time effects on neuropsychological performance and their relation to functional outcome

Autor: Marta Rapado-Castro, Elisa Rodríguez-Toscano, Gonzalo López, Celso Arango, Maria Mayoral, Jane Lees, Richard Drake, Shôn Lewis

Publikováno v: Schizophrenia research. 216

Cognitive impairment is a major unmet need in the treatment of schizophrenia. Over the last decade, the MATRICS Consensus Cognitive Battery (MCCB) has been used to assess the effects of novel treatments for cognitive impairment in schizophrenia. Howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9df5dbdd78dfc46d643f79b4b243ce
https://pubmed.ncbi.nlm.nih.gov/31813804

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F133. A LONGITUDINAL COMPARISON OF TWO NEUROCOGNITIVE ASSESSMENT PACKAGES IN PATIENTS WITH SCHIZOPHRENIA AND HEALTHY VOLUNTEERS: TIME EFFECTS ON NEUROPSYCHOLOGICAL PERFORMANCE AND ITS RELATION TO FUNCTIONAL OUTCOME

Autor: Elisa Rodríguez-Toscano, Richard Drake, Marta Rapado-Castro, Shôn Lewis, Celso Arango, María José Mayoral, Jane Lees, Gonzalo López

Publikováno v: Schizophrenia Bulletin. 45:S304-S305

BACKGROUND: Cognitive impairment is a major unmet need in the treatment of schizophrenia. Over the last decade, the MATRICS Consensus Cognitive Battery (MCCB) and the cognitive-neuroscience-based Cambridge Neuropsychological Test Automated Battery (C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b86166a221ce61ed4d78a7c3b01852b
https://doi.org/10.1093/schbul/sbz018.545

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Calibration and cross-validation of MCCB and CogState in schizophrenia

Autor: Tracy Collier, Jane Lees, Panayiota G. Michalopoulou, Richard Emsley, Shôn Lewis, Eve Applegate, Richard Drake, Shitij Kapur, Cristina Lopez-Lopez, Gahan Pandina

Publikováno v: BASE-Bielefeld Academic Search Engine

Cognitive impairment associated with schizophrenia is a key predictor of functional outcomes. The FDA-accepted MATRICS Consensus Cognitive Battery (MCCB) is held to be the gold standard measure but there are concerns about its ease of administration,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84af0b2d0bce6bef30c364f3cb4a0b39
https://doi.org/10.1007/s00213-015-3960-8

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