Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jane L. Wang"'
Autor:
Ann E. Hallinan, Jeffery S. Carter, David G. Brown, John J. Talley, Timothy Maziasz, Karl W. Aston, Bruce C. Hamper, Matthew J. Graneto, Koszyk Francis, Jaime L. Masferrer, Ludwig Cindy L, Jane L. Wang, David C. Limburg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7164-7168
In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. We provide the structure–activity relationships, optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca972ff580b09dc552a085ce8062ac97
https://doi.org/10.1016/j.bmcl.2010.07.059
https://doi.org/10.1016/j.bmcl.2010.07.059
Autor:
Stephen J. Mnich, Olga V. Nemirovskiy, James K. Gierse, Gabriel Mbalaviele, Adele M. Pauley, Alexander F. Shaffer, William M. Moore, Sumathy Mathialagan, Ben S. Zweifel, Jeffrey S. Carter, Jaime L. Masferrer, Michael L. Vazquez, Jane L. Wang
Publikováno v:
Biochemical Pharmacology. 79:1445-1454
Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2). The efficacy of nonsteroidal anti-inflammatory drugs and COX-2 inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f2b47310c2ae7d1f319e11e57535cc
https://doi.org/10.1016/j.bcp.2010.01.003
https://doi.org/10.1016/j.bcp.2010.01.003
3-Methyl-4H-[1,2,4]-oxadiazol-5-one: a versatile synthon for protecting monosubstituted acetamidines
Autor:
Jeffery S. Snyder, James A. Sikorski, Michele A. Promo, Jane L. Wang, Katherine E. Palmquist, Alan E. Moormann, Mark A. Massa, Jeffrey A. Scholten, R. Keith Webber
Publikováno v:
Tetrahedron. 60:10907-10914
The utilization of 3-methyl-4H-[1,2,4]-oxadiazol-5-one as a versatile protected acetamidine is demonstrated through employment in a variety of synthetic sequences. The potassium salt ( 2a ) or the neutral form ( 2b ) is alternatively shown to be supe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21e3af81b43f1cbb052c362752de440e
https://doi.org/10.1016/j.tet.2004.09.030
https://doi.org/10.1016/j.tet.2004.09.030
Autor:
Jane L. Wang, Michael B. Tollefson, Margaret L. Grapperhaus, James A. Sikorski, Richard C. Durley, Monica B. Norton, Michele A. Promo, Michele A. Melton, Mark A. Massa, Emily J. Reinhard, Brian S. Hickory, William F. Vernier, Mark E. Smith, Yvette M. Fobian, Karen Regina, Bryan J. Witherbee, Daniel T. Connolly
Publikováno v:
Journal of Medicinal Chemistry. 46:2152-2168
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b10e457203bbb1110208e3911dfa6aac
https://doi.org/10.1021/jm020528+
https://doi.org/10.1021/jm020528+
Autor:
Michele A Melton, Nigam P. Rath, Ming Zeng, Margaret L. Grapperhaus, Brian S Hickory, Jane L Wang, Elaine S. Krul, Deborah M. Heuvelman, Mark E. Smith, Kevin C. Glenn, Richard C Durley, Deborah A. Mischke, Bryan J. Witherbee, Daniel T. Connolly, Dale P Spangler, Dorothy D. Honda, Yvette M. Fobian, James A. Sikorski, Mark A. Massa, Barry L. Parnas
Publikováno v:
Journal of Medicinal Chemistry. 45:3891-3904
A novel series of substituted N-benzyl-N-phenyl-trifluoro-3-amino-2-propanols are described that reversibly inhibit cholesteryl ester transfer protein (CETP). Starting with screening lead 22, various structural features were explored with respect to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054e4cc40c00d2928100cc032ffe6208
https://doi.org/10.1021/jm020038h
https://doi.org/10.1021/jm020038h
Autor:
Sarah E. Smith, Scott J. Bowen, Scott A. Long, David Beidler, Marvin J. Meyers, Atli Thorarensen, Heather M. Madsen, Joseph J. McDonald, Susan Foltin, Barbara A. Schweitzer, Tenbrink Ruth E, Jane L. Wang, Mark C. Walker, Matthew James Pelc
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
Herein we report the identification of two new fatty acid amide hydrolase (FAAH) inhibitor lead series with FAAH k(inact)/K(i) potency values greater than 1500M(-1)s(-1). The two novel spirocyclic cores, 7-azaspiro[3.5]nonane and 1-oxa-8-azaspiro[4.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7438967a60497c300b8da344350b5239
https://pubmed.ncbi.nlm.nih.gov/21924614
https://pubmed.ncbi.nlm.nih.gov/21924614
Autor:
Sarah E. Smith, Marvin J. Meyers, Young-Sun Yang, Joseph J. McDonald, David Beidler, Atli Thorarensen, Matthew James Pelc, Jeanne M. Rumsey, Mark V. Wilcox, Satwik Kamtekar, Scott A. Long, Scott J. Bowen, Jane L. Wang, Mark C. Walker, Susan Foltin, Barbara A. Schweitzer
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(21)
Fatty acid amide hydrolase (FAAH) is an integral membrane serine hydrolase responsible for the degradation of fatty acid amide signaling molecules such as endocannabinoid anandamide (AEA), which has been shown to possess cannabinoid-like analgesic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3804bc72bde947f3e055de3b9ae0157
https://pubmed.ncbi.nlm.nih.gov/21924613
https://pubmed.ncbi.nlm.nih.gov/21924613
Autor:
Jane L. Wang, et al. et al.
Publikováno v:
ChemInform. 42
Design, synthesis, SAR, and human half-life data of a novel series of potent and selective COX-2 inhibitors (I) based on the 2-trifluoromethyl-2H-benzopyran-3-carboxylic acid scaffold are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864b057173993ecc67229934d6229c1f
https://doi.org/10.1002/chin.201115200
https://doi.org/10.1002/chin.201115200
Autor:
Matthew James Pelc, Heather M. Madsen, Joseph J. McDonald, Scott J. Bowen, Barbara A. Schweitzer, David Beidler, Atli Thorarensen, Tenbrink Ruth E, Jane L. Wang
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(20)
Fatty acid amide hydrolase (FAAH) has attracted significant attention due to its promise as an analgesic target. This has resulted in the discovery of numerous chemical classes as inhibitors of this potential therapeutic target. In this paper we disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3e5e4475461d15a8771bc5fc71c1c6
https://pubmed.ncbi.nlm.nih.gov/19765986
https://pubmed.ncbi.nlm.nih.gov/19765986
Autor:
Emily J, Reinhard, Jane L, Wang, Richard C, Durley, Yvette M, Fobian, Margaret L, Grapperhaus, Brian S, Hickory, Mark A, Massa, Monica B, Norton, Michele A, Promo, Michael B, Tollefson, William F, Vernier, Daniel T, Connolly, Bryan J, Witherbee, Michele A, Melton, Karen J, Regina, Mark E, Smith, James A, Sikorski
Publikováno v:
Journal of medicinal chemistry. 46(11)
A novel series of substituted N-[3-(1,1,2,2-tetrafluoroethoxy)benzyl]-N-(3-phenoxyphenyl)-trifluoro-3-amino-2-propanols is described which potently and reversibly inhibit cholesteryl ester transfer protein (CETP). Starting from the initial lead 1, va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d9119f562ad78addf9a4a9fd8706b8e
https://pubmed.ncbi.nlm.nih.gov/12747787
https://pubmed.ncbi.nlm.nih.gov/12747787