Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jane L. Burrows"'
Autor:
Emilio F. Stuart, Nick Clarke, Paul Alan Glossop, Neil Feeder, Strang Ross Sinclair, J. W. Watson, Jane L. Burrows, Amy S. Kenyon, Matthew D. Selby, Michael A. Trevethick, Sheena Patel, Rhys M. Jones, Kim James, Karen N. Wright, Dannielle Frances Roberts, Lyn H. Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5121-5126
A 1,2,4-triazole motif was employed as a bioisostere for the ester commonly used in muscarinic antagonists, and subsequent integrative conjugation to a β2 agonist quinolinone furnished a new class of bifunctional MABAs for the treatment of COPD. Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b09018de8f7e915b91637ee9153193
https://doi.org/10.1016/j.bmcl.2015.10.008
https://doi.org/10.1016/j.bmcl.2015.10.008
Publikováno v:
International Journal of Pharmaceutics. 372:97-104
The controlled co-delivery of multiple agents to the lung offers potential benefits to patients. This study investigated the preparation and characterisation of highly respirable spray-dried powders displaying the sustained release of two chemically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaa72216ec94839f629c3b83ce85cbc
https://doi.org/10.1016/j.ijpharm.2009.01.017
https://doi.org/10.1016/j.ijpharm.2009.01.017
Publikováno v:
Powder Technology. 187:231-238
Dry powders for inhalation were prepared by spray drying a 30% v/v aqueous ethanol formulation containing beclometasone dipropionate (BDP), lactose, leucine and chitosan (low, medium or high molecular weight (MW), or combinations thereof). Following
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f03175dc7f1ad1533e3ac4e6c0a2dce8
https://doi.org/10.1016/j.powtec.2008.02.015
https://doi.org/10.1016/j.powtec.2008.02.015
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 68:224-234
In this study, we describe the preparation of highly dispersible dry powders for pulmonary drug delivery that display sustained drug release characteristics. Powders were prepared by spray-drying 30% v/v aqueous ethanol formulations containing terbut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95017784c2f2a70254cdd3c1c3e19d7
https://doi.org/10.1016/j.ejpb.2007.04.017
https://doi.org/10.1016/j.ejpb.2007.04.017
Autor:
Robert T. Smith, Jane L. Burrows, Arnaud Lemaitre, Samantha Hughes, Peter G. Dodd, Tim J. Evans, Russell Andrew Lewthwaite, Mathias John Paul, Mark H. Stefaniak, Michael Yeadon, James Philip, David S. Millan, Mark E. Bunnage, Christopher Phillips, Kenneth John Butcher, Iain Kilty, David Fairman, Axel Mahnke
Publikováno v:
Journal of medicinal chemistry. 54(22)
This paper describes the identification and optimization of a novel series of DFG-out binding p38 inhibitors as inhaled agents for the treatment of chronic obstructive pulmonary disease. Structure based drug design and "inhalation by design" principl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cff411c95d8e91f42d706bb7fab72f
https://pubmed.ncbi.nlm.nih.gov/21888439
https://pubmed.ncbi.nlm.nih.gov/21888439
Autor:
Paul A, Glossop, Christine A L, Watson, David A, Price, Mark E, Bunnage, Donald S, Middleton, Anthony, Wood, Kim, James, Dannielle, Roberts, Ross S, Strang, Michael, Yeadon, Christelle, Perros-Huguet, Nicholas P, Clarke, Michael A, Trevethick, Ian, Machin, Emilio F, Stuart, Steven M, Evans, Anthony C, Harrison, David A, Fairman, Balaji, Agoram, Jane L, Burrows, Neil, Feeder, Craig K, Fulton, Barry R, Dillon, David A, Entwistle, Fiona J, Spence
Publikováno v:
Journal of medicinal chemistry. 54(19)
A novel tertiary amine series of potent muscarinic M(3) receptor antagonists are described that exhibit potential as inhaled long-acting bronchodilators for the treatment of chronic obstructive pulmonary disease. Geminal dimethyl functionality presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::22c240e08044f99a090aa8ee4d570ee8
https://pubmed.ncbi.nlm.nih.gov/21870878
https://pubmed.ncbi.nlm.nih.gov/21870878
Autor:
Craig K. Fulton, David Price, Kim James, Mark E. Bunnage, Sandra D. Newman, Sheena Patel, Jane L. Burrows, Emilio F. Stuart, Rachel Osborne, Stuart Marshall, Nick Clarke, Matthew D. Selby, Neil Feeder, David A. Entwistle, Helen Baldock, Rhys M. Jones, Michele Coghlan, Laura Hilton, Michael A. Trevethick, Karen N. Wright, David Fairman, Lyn H. Jones, Amy S. Kenyon
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
This paper describes the successful design and development of dual pharmacology β-2 agonists-M3 antagonists, for the treatment of chronic obstructive pulmonary disorder using the principles of 'inhalation by design'. A key feature of this work is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2972c74e7582b1b629c2304ccadb40
https://pubmed.ncbi.nlm.nih.gov/21075627
https://pubmed.ncbi.nlm.nih.gov/21075627
Autor:
Mark E. Bunnage, Neil Feeder, Jane L. Burrows, Russell Andrew Lewthwaite, Fiona J. Spence, Paul Alan Glossop, Rob Webster, Charlotte Alice Louise Lane, Nick Clarke, Michael A. Trevethick, Alan Daniel Brown, Kim James, David Price, Christelle Perros-Huguet, Michael Yeadon, Stefan Colin John Taylor, Rhys M. Jones
Publikováno v:
Journal of medicinal chemistry. 53(18)
A novel series of potent and selective sulfonamide derived β(2)-adrenoreceptor agonists are described that exhibit potential as inhaled ultra-long-acting bronchodilators for the treatment of asthma and chronic obstructive pulmonary disease. Analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc875336d8663d76b989496877976324
https://pubmed.ncbi.nlm.nih.gov/20804199
https://pubmed.ncbi.nlm.nih.gov/20804199
Publikováno v:
Journal of microencapsulation. 27(2)
The sustained delivery of multiple agents to the lung offers potential benefits to patients. This study explores the preparation of highly respirable dual-loaded spray-dried double emulsions. Spray-dried powders were produced from water-in-oil-in-wat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf24ccd54ef5c3fdc05c03a8a3a76c7b
https://pubmed.ncbi.nlm.nih.gov/19538030
https://pubmed.ncbi.nlm.nih.gov/19538030
Autor:
C Fulton, Hiroki Mori, Kristina Ulrich, J Janies, L Whybrow, Stephen Ballard, Jane L. Burrows, Nicole S. Parker, Nazanin Farhadi, David J. Lamb, S Allen, Mike Yeadon, G J Douglas, Rhys M. Jones, J Parnell
Publikováno v:
C30. INFLAMMATORY AND IMMUNOLOGICAL MODELS OF ASTHMA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e207861f57ff056fbcf5b8e30c1d17
https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4220
https://doi.org/10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4220