Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jane L, Grogan"'
Autor:
Avantika S. Chitre, Ping Wu, Benjamin T. Walters, Xiangdan Wang, Alexandre Bouyssou, Xiangnan Du, Isabelle Lehoux, Rina Fong, Alisa Arata, Joyce Chan, Die Wang, Yvonne Franke, Jane L. Grogan, Ira Mellman, Laetitia Comps-Agrar, Weiru Wang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of T-cell receptor signaling and as such is an attractive target for cancer immunotherapy. Although the role of the HPK1 kinase domain (KD) has been extensively characterized,
Externí odkaz:
https://doaj.org/article/606ad94308a5488bb57edc5d41149491
Autor:
Juan A. Perez-Bermejo, Oghene Efagene, William M. Matern, Jeffrey K. Holden, Shaheen Kabir, Glen M. Chew, Gaia Andreoletti, Eniola Catton, Craig L. Ennis, Angelica Garcia, Trevor L. Gerstenberg, Kaisle A. Hill, Aayami Jain, Kristina Krassovsky, Cassandra D. Lalisan, Daniel Lord, B. Joy Quejarro, Jade Sales-Lee, Meet Shah, Brian J. Silva, Jason Skowronski, Yuri G. Strukov, Joshua Thomas, Michael Veraz, Twaritha Vijay, Kirby A. Wallace, Yue Yuan, Jane L. Grogan, Beeke Wienert, Premanjali Lahiri, Sebastian Treusch, Daniel P. Dever, Vanessa B. Soros, James R. Partridge, Kristen L. Seim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Homology Directed Repair (HDR) enables precise genome editing, but the implementation of HDR-based therapies is hindered by limited efficiency in comparison to methods that exploit alternative DNA repair routes, such as Non-Homologous End Jo
Externí odkaz:
https://doaj.org/article/620ea33bf16f4f77a76fcba73efa8992
Autor:
Sairy Hernandez, Jing Qing, Rebecca Hong Thibodeau, Xiangnan Du, Summer Park, Hyang-Mi Lee, Min Xu, Soyoung Oh, Armando Navarro, Meron Roose-Girma, Robert J. Newman, Soren Warming, Michelle Nannini, Deepak Sampath, Jeong M. Kim, Jane L. Grogan, Ira Mellman
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 80-94 (2018)
Summary: We examined hematopoietic protein kinase 1 (HPK1), whose reliance on scaffold versus kinase functions for negative immune cell regulation is poorly understood and critical to its assessment as a viable drug target. We identify kinase-depende
Externí odkaz:
https://doaj.org/article/b83897a71cd24096b600c382ba7050d8
Autor:
Prasad S. Adusumilli, Edward Cha, Mark Cornfeld, Thomas Davis, Adi Diab, Thomas W. Dubensky, Elizabeth Evans, Jane L. Grogan, Bryan A. Irving, Rom S. Leidner, Shane A. Olwill, Patrick Soon-Shiong, Frederic Triebel, David Tuck, Adrian Bot, Roger D. Dansey, Charles G. Drake, Gordon J. Freeman, Ramy Ibrahim, Salil Patel, Daniel S. Chen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-9 (2017)
Abstract This report is a summary of ‘New Cancer Immunotherapy Agents in Development’ program, which took place in association with the 31st Annual Meeting of the Society for Immunotherapy of Cancer (SITC), on November 9, 2016 in National Harbor,
Externí odkaz:
https://doaj.org/article/5bb5a295fe6b4f3fa973a3c47fce0e74
Autor:
Eugene Y. Chiang, Tianbo Li, Surinder Jeet, Ivan Peng, Juan Zhang, Wyne P. Lee, Jason DeVoss, Patrick Caplazi, Jun Chen, Søren Warming, David H. Hackos, Susmith Mukund, Christopher M. Koth, Jane L. Grogan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Potassium channels are essential for modulating T-cell functions. Here, by characterizing rat models and analysing human T cells, the authors identify differential requirements of two potassium channel proteins, Kv1.3 and KCa3.1, for the induction of
Externí odkaz:
https://doaj.org/article/e81be3fdce5148d7897e24bc26448b4f
Autor:
Denise E. de Almeida Nagata, Eugene Y. Chiang, Suchit Jhunjhunwala, Patrick Caplazi, Vidhyalakshmi Arumugam, Zora Modrusan, Emily Chan, Mark Merchant, Lingyan Jin, David Arnott, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne, Jane L. Grogan
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 269-281.e4 (2019)
Summary: Myeloid-derived suppressor cells (MDSCs) are found in most cancer malignancies and support tumorigenesis by suppressing immunity and promoting tumor growth. Here we identify the bromodomain (BRD) of CBP/EP300 as a critical regulator of H3K27
Externí odkaz:
https://doaj.org/article/59bed4a4121e435abacf7f0ac7ad65fe
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180154 (2017)
Ion channels regulate a variety of physiological processes and represent an important class of drug target. Among the many methods of studying ion channel function, patch clamp electrophysiology is considered the gold standard by providing the ultima
Externí odkaz:
https://doaj.org/article/ef68edb4cf624a2ea96e09142c796ffa
Autor:
Thomas Powles, Vinita Gupta, Zora Modrusan, Shravan Madireddi, Kobe C. Yuen, Romain Banchereau, Darren Tayama, Jane L. Grogan, Deepali Rishipathak, Patrick Williams, Edward E. Kadel, Sanjeev Mariathasan, Kenji Hashimoto, Jonathan E. Rosenberg, Shilpa Keerthivasan, Ying-Jiun Chen, Hartmut Koeppen, David F. McDermott, Congfen Li, Mahrukh Huseni, A. Thåström, X. Shen, Ning Leng, Li-Fen Liu, Michiel S. van der Heijden, Priti S. Hegde
Publikováno v:
Nature medicine, 26(5), 693-698. Nature Publishing Group
Nat Med
Nat Med
Although elevated plasma interleukin-8 (pIL-8) has been associated with poor outcome to immune checkpoint blockade 1, this has not been comprehensively evaluated in large randomized studies. Here we analyzed circulating pIL-8 and IL8 gene expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e57f9c6f06d90af2db552915b0ec30
https://doi.org/10.1038/s41591-020-0860-1
https://doi.org/10.1038/s41591-020-0860-1
Autor:
Youngsu Kwon, Avantika S. Chitre, Denise E. de Almeida Nagata, Karl L. Banta, Stephanie Mittman, Keith R. Anderson, Rafael Cubas, Kristin Harden Bowles, Patrícia de Almeida, Eugene Y. Chiang, Xiangnan Du, Søren Warming, Jane L. Grogan, Brent S. McKenzie
Publikováno v:
European Journal of Immunology. 50:891-902
CD96 is a member of the poliovirus receptor (PVR, CD155)-nectin family that includes T cell Ig and ITIM domain (TIGIT) and CD226. While CD96, TIGIT, and CD226 have important roles in regulating NK cell activity, and TIGIT and CD226 have also been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4ca155c5655ee151dba33f44f53989f
https://doi.org/10.1002/eji.201948405
https://doi.org/10.1002/eji.201948405
Autor:
Karl L, Banta, Xiaozheng, Xu, Avantika S, Chitre, Amelia, Au-Yeung, Chikara, Takahashi, William E, O'Gorman, Thomas D, Wu, Stephanie, Mittman, Rafael, Cubas, Laetitia, Comps-Agrar, Amit, Fulzele, Eric J, Bennett, Jane L, Grogan, Enfu, Hui, Eugene Y, Chiang, Ira, Mellman
Publikováno v:
Immunity. 55(3)
Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT blockade modulate anti-tumor CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d237098913f41245956df8c61565e97
https://pubmed.ncbi.nlm.nih.gov/35263569
https://pubmed.ncbi.nlm.nih.gov/35263569