Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jane Knöchel"'
Autor:
Jane Knöchel, Linnéa Bergenholm, Eman Ibrahim, Stergios Kechagias, Sara Hansson, Mathias Liljeblad, Patrik Nasr, Björn Carlsson, Mattias Ekstedt, Sebastian Ueckert
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 12, Pp 2038-2049 (2023)
Abstract Disease progression in nonalcoholic steatohepatitis (NASH) is highly heterogenous and remains poorly understood. Fibrosis stage is currently the best predictor for development of end‐stage liver disease and mortality. Better understanding
Externí odkaz:
https://doaj.org/article/bf1703e2ce564bf6916f27c82905c8b3
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 2, p e1011777 (2024)
In systems biology and pharmacology, large-scale kinetic models are used to study the dynamic response of a system to a specific input or stimulus. While in many applications, a deeper understanding of the input-response behaviour is highly desirable
Externí odkaz:
https://doaj.org/article/04555528c2e84b979110c8c4ef630ac7
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 4, Pp 432-443 (2023)
Abstract Quantitative systems pharmacology (QSP) models integrate comprehensive qualitative and quantitative knowledge about pharmacologically relevant processes. We previously proposed a first approach to leverage the knowledge in QSP models to deri
Externí odkaz:
https://doaj.org/article/3d25fbf05ad54d40bd575c869072b6cf
Autor:
Jane Knöchel, Catarina Nilsson, Björn Carlsson, Linda Wernevik, Alexis Hofherr, Peter Gennemark, Rasmus Jansson‐Löfmark, Rikard Isaksson, Tina Rydén‐Bergsten, Bengt Hamrén, Dinko Rekić
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 12, Pp 1569-1577 (2022)
Abstract Here, we show model‐informed drug development (MIDD) of a novel antisense oligonucleotide, targeting PCSK9 for treatment of hypocholesteremia. The case study exemplifies use of MIDD to analyze emerging data from an ongoing first‐in‐hum
Externí odkaz:
https://doaj.org/article/e7f981bc8d2c4134ac07a117e385317e
Autor:
Elke Ericson, Linnéa Bergenholm, Anne‐Christine Andréasson, Carly I. Dix, Jane Knöchel, Sara F. Hansson, Richard Lee, Jennifer Schumi, Madeleine Antonsson, Ola Fjellström, Patrik Nasr, Mathias Liljeblad, Björn Carlsson, Stergios Kechagias, Daniel Lindén, Mattias Ekstedt
Publikováno v:
Hepatology Communications, Vol 6, Iss 10, Pp 2689-2701 (2022)
Abstract In nonalcoholic fatty liver disease (NAFLD) the patatin‐like phospholipase domain‐containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration
Externí odkaz:
https://doaj.org/article/09395c29b57e4f08a41e517a3c5a8290
Autor:
Jane Knöchel, Catarina Nilsson, Björn Carlsson, Linda Wernevik, Alexis Hofherr, Peter Gennemark, Rasmus Jansson‐Löfmark, Rikard Isaksson, Tina Rydén‐Bergsten, Bengt Hamrén, Dinko Rekić
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 11:1569-1577
Autor:
Elke Ericson, Linnéa Bergenholm, Anne‐Christine Andréasson, Carly I. Dix, Jane Knöchel, Sara F. Hansson, Richard Lee, Jennifer Schumi, Madeleine Antonsson, Ola Fjellström, Patrik Nasr, Mathias Liljeblad, Björn Carlsson, Stergios Kechagias, Daniel Lindén, Mattias Ekstedt
Publikováno v:
Hepatology Communications. 6:2689-2701
In nonalcoholic fatty liver disease (NAFLD) the patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 variant is a contributor. In mice, the Pnpla3 148M variant accumulates on lipid droplets and probably leads to sequestration of a lipase
Autor:
Dinko Rekić, Ivan Azarov, Jane Knöchel, Victor Sokolov, Catarina Nilsson, Linda Wernevik, David Han, Tina Rydén‐Bergsten, Ahmad Ebrahimi, Corina Dota, Björn Carlsson
Publikováno v:
British Journal of Clinical Pharmacology. 88:4839-4844
AZD8233 is a proprotein convertase subtilisin/kexin type 9 (PCSK9) antisense oligonucleotide under development for treatment of hypercholesterolaemia. A prespecified concentration-QT analysis was performed based on data from a single ascending dose s
Autor:
Konstantina Psachoulia, Eva-Lotte Lindstedt, Carl Whatling, Gordon Law, Iain MacPhee, Hans Ericsson, Hiddo J.L. Heerspink, Kathleen Connolly, Jane Knöchel
Publikováno v:
Kidney International Reports
Kidney International Reports, 6(11), 2803-2810. ELSEVIER SCIENCE INC
Kidney International Reports, 6(11), 2803-2810. ELSEVIER SCIENCE INC
Introduction Patients with chronic kidney disease (CKD) remain at risk for kidney and cardiovascular events resulting from residual albuminuria, despite available treatments. Leukotrienes are proinflammatory and vasoconstrictive lipid mediators impli
Autor:
Maria Heijer, Carl Whatling, Hitoshi Shimada, Anders Gabrielsen, Eva-Lotte Lindstedt, Karin Nelander, Jane Knöchel, Gun-Britt Forsberg, Hans Ericsson, David S. Han, Pavlo Garkaviy
Publikováno v:
Clinical Drug Investigation
Background and Objective AZD5718, a 5-lipoxygenase-activating protein (FLAP) inhibitor, is in clinical development for treatment of coronary artery disease (CAD) and chronic kidney disease (CKD). This study evaluated AZD5718 pharmacokinetics, pharmac