Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jane K. La Du"'
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 202-210 (2017)
Nitroreductase enzymes are responsible for the reduction of nitro functional groups to amino functional groups, and are found in a range of animal models, zebrafish (Danio rerio) excluded. Transgenic zebrafish models have been developed for tissue-sp
Externí odkaz:
https://doaj.org/article/bcbd2021b6634e16b40815aeb5261f7a
Autor:
Subham Dasgupta, Jane K La Du, Gloria R Garcia, Sizhen Li, Konoha Tomono-Duval, Yvonne Rericha, Liang Huang, Robyn L Tanguay
Publikováno v:
Toxicological Sciences.
The role of long non-coding RNAs (lncRNAs) regulators of toxicological responses to environmental chemicals is gaining prominence. Previously, our laboratory discovered a lncRNA, sox9b long intergenic noncoding RNA (slincR), that is activated by mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eadd2038a7d4a41240c022163cbb2bb
https://doi.org/10.1093/toxsci/kfad050
https://doi.org/10.1093/toxsci/kfad050
Autor:
Prarthana Shankar, Gloria R Garcia, Jane K La Du, Christopher M Sullivan, Cheryl L Dunham, Britton C Goodale, Katrina M Waters, Stanislau Stanisheuski, Claudia S Maier, Preethi Thunga, David M Reif, Robyn L Tanguay
Publikováno v:
Toxicol Sci
The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). AHR activation is well-understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca4427ca8a9658b5e08a8000cbc6f81
https://europepmc.org/articles/PMC9308396/
https://europepmc.org/articles/PMC9308396/
In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression
Autor:
Britton C. Goodale, Michelle W. Wiley, Jane K. La Du, Gloria R. Garcia, David A. Hendrix, Robert L. Tanguay
Publikováno v:
Molecular Pharmacology. 91:609-619
Xenobiotic activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) prevents the proper formation of craniofacial cartilage and the heart in developing zebrafish. Downstream molecular targets responsible for AHR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f6391cb3ad2db0674594dca68cdfa61
https://doi.org/10.1124/mol.117.108233
https://doi.org/10.1124/mol.117.108233
Autor:
Susan C. Tilton, Prarthana Shankar, Robert L. Tanguay, Jane K. La Du, Cheryl L. Dunham, Abraham Garcia, Gloria R. Garcia, Lisa Truong
Publikováno v:
Environmental Health Perspectives
Background: A structurally diverse group of chemicals, including dioxins [e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)] and polycyclic aromatic hydrocarbons (PAHs), can xenobiotically activate the aryl hydrocarbon receptor (AHR) and contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f984df5f5e0609e3bab0af5235e8fc47
https://doi.org/10.1289/ehp3281
https://doi.org/10.1289/ehp3281
Autor:
Jane K. La Du, Robert L. Tanguay, David M. Reif, Michele Balik-Meisner, Elizabeth H. Scholl, Lisa Truong
Publikováno v:
Environmental Health Perspectives
Background: Modern societies are exposed to vast numbers of potentially hazardous chemicals. Despite demonstrated linkages between chemical exposure and severe health effects, there are limited, often conflicting, data on how adverse health effects o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0754fdbd36250b1b1b4086113dc5d65
https://pubmed.ncbi.nlm.nih.gov/29968567
https://pubmed.ncbi.nlm.nih.gov/29968567
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 4, Iss, Pp 202-210 (2017)
Toxicology Reports, Vol 4, Iss, Pp 202-210 (2017)
Highlights • Nitroreductase-mediated tissue ablation is a useful technique in zebrafish. • Hepatic ablation can occur during early or late liver development. • Nitroreductase activity can be used for cell ablation or toxicity testing. • Chemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1279995164b7d82c3490b423c122af5f
https://pubmed.ncbi.nlm.nih.gov/28758069
https://pubmed.ncbi.nlm.nih.gov/28758069
Autor:
Gloria R, Garcia, Britton C, Goodale, Michelle W, Wiley, Jane K, La Du, David A, Hendrix, Robert L, Tanguay
Publikováno v:
Molecular Pharmacology
Xenobiotic activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) prevents the proper formation of craniofacial cartilage and the heart in developing zebrafish. Downstream molecular targets responsible for AHR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7b0aa78b06468d18b4a62d25ec2b46b
https://pubmed.ncbi.nlm.nih.gov/28385905
https://pubmed.ncbi.nlm.nih.gov/28385905
Autor:
Robert L. Tanguay, Susan C. Tilton, Sean M. Bugel, Katrina M. Waters, Jane K. La Du, Jill A. Franzosa, Tamara Tal
Publikováno v:
The FASEB Journal. 27:4866-4876
Retinoic acid (RA) is involved in multifarious and complex functions necessary for vertebrate development. RA signaling is reliant on strict enzymatic regulation of RA synthesis and metabolism. Improper spatiotemporal expression of RA during developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40956f27610b3074339dc831b008890e
https://doi.org/10.1096/fj.12-225524
https://doi.org/10.1096/fj.12-225524
Publikováno v:
Toxicology and applied pharmacology. 296
The zebrafish is a powerful alternative model used to link phenotypes with molecular effects to discover drug mode of action. Using a zebrafish embryo-larval toxicity bioassay, we evaluated the effects of tamoxifen--a widely used anti-estrogen chemot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdabbbcd8f64205c39648cfb3fa8b938
https://pubmed.ncbi.nlm.nih.gov/26908177
https://pubmed.ncbi.nlm.nih.gov/26908177