Výsledky vyhledávání - "Jane K, Relton"

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

Autor: Rafael Wabl, Nina Fainberg, Jeffrey W. Pollard, Jian Luo, Ruth Getachew, Haitham Alabsi, Saul A. Villeda, Sanjiv S. Gambhir, Hui Zhang, Markus Britschgi, Gordon Wong, Liyin Zhu, Michelle L. James, Jane K. Relton, Zhaoqing Ding, Tony Wyss-Coray, Ramya Narasimhan, Fiona Elwood

Publikováno v: Luo, J, Elwood, F, Britschgi, M, Villeda, S, Zhang, H, Ding, Z, Zhu, L, Alabsi, H, Getachew, R, Narasimhan, R, Wabl, R, Fainberg, N, James, M L, Wong, G, Relton, J, Gambhir, S S, Pollard, J W & Wyss-Coray, T 2013, ' Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival ', Journal of Experimental Medicine, vol. 210, no. 1, pp. 157-72 . https://doi.org/10.1084/jem.20120412
The Journal of Experimental Medicine

Colony-stimulating factor 1 and IL-34 protect against and partially reverse neurodegeneration in mice in part via promoting CREB signaling.
Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the CSF1 receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ccd5a4787d9035d0e0c883eebb2788
https://doi.org/10.1084/jem.20120412

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Sickness behaviour is induced by a peripheral CXC-chemokine also expressed in multiple sclerosis and EAE

Autor: S Mardiguian, Sandra J. Campbell, Yanyan Jiang, Daniel C. Anthony, Thomas J. Connor, Ute C. Meier, Edward T. Littleton, Adrian Bristow, Jane K. Relton

Non-CNS chemokine production may contribute to previously unrecognised components of Multiple Sclerosis (MS) pathology. Here we show that IL-8, a neutrophil chemoattractant, is significantly increased in serum from individuals with MS, and that the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a59b38e3fcb2c49f8a37c1d68d6785
https://ora.ox.ac.uk/objects/uuid:28cae585-6693-4542-af9d-d86a0666fb1c

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Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering

Autor: Joy Wang, Dingyi Wen, Joseph Amatucci, Lee Walus, Paul H. Weinreb, Fang Qian, Jane K. Relton, Frank Porreca, Werner Meier, Laura Silvian, Ellen Garber, R. Blake Pepinsky, Ruizhong Wang, Craig P. Wildes, Daniel H. S. Lee, Mi‑young Jung

Publikováno v: Biotechnology and Applied Biochemistry. 57:31-45

NgRI (Nogo-66 receptor) is part of a signalling complex that inhibits axon regeneration in the central nervous system. Truncated soluble versions of NgRI have been used successfully to promote axon regeneration in animal models of spinal-cord injury,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4700c6873ee609d7513dc6fc00e61a3f
https://doi.org/10.1042/ba20100061

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The Role of Bradykinin B1 and B2 Receptors for Secondary Brain Damage after Traumatic Brain Injury in Mice

Autor: Juerg Nussberger, Jane K. Relton, Werner Müller-Esterl, Klaus Zweckberger, Nikolaus Plesnila, Raimund Trabold, Michael Bader, Christian Erös, Eric T. Whalley, Heike Beck

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 30:130-139

Inflammatory mechanisms are known to contribute to the pathophysiology of traumatic brain injury (TBI). Since bradykinin is one of the first mediators activated during inflammation, we investigated the role of bradykinin and its receptors in posttrau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0f72a5ee74a7240f083e0b54117e48
https://doi.org/10.1038/jcbfm.2009.196

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Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons

Autor: Alex Verkhratsky, Nancy J. Rothwell, Jane K. Relton, Martin J. Humphries, P. Marc D. Watson, Rosemary M. Gibson

Publikováno v: Molecular and Cellular Neuroscience. 34:147-154

Integrins mediate cell adhesion to the extracellular matrix and initiate intracellular signaling. They play key roles in the central nervous system (CNS), participating in synaptogenesis, synaptic transmission and memory formation, but their precise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c700d1a7d06be99b72f4248d009ceceb
https://doi.org/10.1016/j.mcn.2006.10.007

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LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

Autor: Benxiu Ji, R. Blake Pepinsky, Bryan Sands, Xinhua Lee, Richard L. Cate, Zhaohui Shao, Greg Thill, Norm Allaire, Melissa Levesque, Sha Mi, Thomas Crowell, Steve Perrin, Jane K. Relton, John M. Mccoy

Publikováno v: Nature Neuroscience. 7:221-228

Axon regeneration in the adult CNS is prevented by inhibitors in myelin. These inhibitors seem to modulate RhoA activity by binding to a receptor complex comprising a ligand-binding subunit (the Nogo-66 receptor NgR1) and a signal transducing subunit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8300b0fe1c1dc93c06f9bc7d69d48d53
https://doi.org/10.1038/nn1188

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Inhibition of α4 Integrin Protects Against Transient Focal Cerebral Ischemia in Normotensive and Hypertensive Rats

Autor: Roy R. Lobb, Jane K. Relton, Steven P. Adams, Erica M. Frew, Eric T. Whalley, Kevin E. Sloan

Publikováno v: Stroke. 32:199-205

Background and Purpose —The present study was performed to determine the role of α4 (CD49d), a member of the integrin family of adhesion molecules, in ischemic brain pathology. Methods —Male spontaneously hypertensive rats (SHR) or Sprague-Dawle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4d91a631c5567302cb6b1d859e0ee7
https://doi.org/10.1161/01.str.32.1.199

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Involvement of cytokines in acute neurodegeneration in the CNS

Autor: Jane K. Relton, Nancy J. Rothwell

Publikováno v: Neuroscience & Biobehavioral Reviews. 17:217-227

Cytokines, (particularly interleukins and growth factors) are synthesised in the brain, and induced by brain damage. Interleukin-I appears to directly mediate ischaemic and excitotoxic brain damage, whereas growth factors (e.g., bFGF, NGF), and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf95eb1781cc677173f20a2082890b2c
https://doi.org/10.1016/s0149-7634(05)80152-6

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Resolution of disulfide heterogeneity in Nogo receptor I fusion proteins by molecular engineering

Autor: Paul H, Weinreb, Dingyi, Wen, Fang, Qian, Craig P, Wildes, Ellen A, Garber, Lee, Walus, Mi-young, Jung, Joy, Wang, Jane K, Relton, Joseph, Amatucci, Ruizhong, Wang, Frank, Porreca, Laura, Silvian, Werner, Meier, R Blake, Pepinsky, Daniel H S, Lee

Publikováno v: Biotechnology and applied biochemistry. 57(1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::00e987069747f988bd86efc6923ecfee
https://pubmed.ncbi.nlm.nih.gov/20815818

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Inhibition of central actions of cytokines on fever and thermogenesis by lipocortin-1 involves CRF

Autor: Paul J. L. M. Strijbos, Nancy J. Rothwell, A. J. Hardwick, Frank Carey, Jane K. Relton

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 263:E632-E636

In the present studies, the mechanisms underlying the inhibitory actions of lipocortin-1 on the pyrogenic and thermogenic properties of cytokines were investigated. Central (icv) injection of corticotropin-releasing factor (CRF, 4.7 micrograms) or th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ac3be1107fdcf40aebe575d771dd99
https://doi.org/10.1152/ajpendo.1992.263.4.e632

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