Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jane K, La Du"'
Autor:
Subham Dasgupta, Jane K La Du, Gloria R Garcia, Sizhen Li, Konoha Tomono-Duval, Yvonne Rericha, Liang Huang, Robyn L Tanguay
Publikováno v:
Toxicological Sciences.
The role of long non-coding RNAs (lncRNAs) regulators of toxicological responses to environmental chemicals is gaining prominence. Previously, our laboratory discovered a lncRNA, sox9b long intergenic noncoding RNA (slincR), that is activated by mult
Publikováno v:
Toxicology Reports, Vol 4, Iss , Pp 202-210 (2017)
Nitroreductase enzymes are responsible for the reduction of nitro functional groups to amino functional groups, and are found in a range of animal models, zebrafish (Danio rerio) excluded. Transgenic zebrafish models have been developed for tissue-sp
Externí odkaz:
https://doaj.org/article/bcbd2021b6634e16b40815aeb5261f7a
Autor:
Prarthana Shankar, Gloria R Garcia, Jane K La Du, Christopher M Sullivan, Cheryl L Dunham, Britton C Goodale, Katrina M Waters, Stanislau Stanisheuski, Claudia S Maier, Preethi Thunga, David M Reif, Robyn L Tanguay
Publikováno v:
Toxicol Sci
The aryl hydrocarbon receptor (AHR) is required for vertebrate development and is also activated by exogenous chemicals, including polycyclic aromatic hydrocarbons (PAHs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). AHR activation is well-understo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca4427ca8a9658b5e08a8000cbc6f81
https://europepmc.org/articles/PMC9308396/
https://europepmc.org/articles/PMC9308396/
Autor:
Britton C Goodale, Jane K La Du, William H Bisson, Derek B Janszen, Katrina M Waters, Robert L Tanguay
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29346 (2012)
The aryl hydrocarbon receptor (AHR) is well known for mediating the toxic effects of TCDD and has been a subject of intense research for over 30 years. Current investigations continue to uncover its endogenous and regulatory roles in a wide variety o
Externí odkaz:
https://doaj.org/article/c8fa8fc591df487a9bb319ce0a0c31cc
In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression
Autor:
Britton C. Goodale, Michelle W. Wiley, Jane K. La Du, Gloria R. Garcia, David A. Hendrix, Robert L. Tanguay
Publikováno v:
Molecular Pharmacology. 91:609-619
Xenobiotic activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) prevents the proper formation of craniofacial cartilage and the heart in developing zebrafish. Downstream molecular targets responsible for AHR
Autor:
Susan C. Tilton, Prarthana Shankar, Robert L. Tanguay, Jane K. La Du, Cheryl L. Dunham, Abraham Garcia, Gloria R. Garcia, Lisa Truong
Publikováno v:
Environmental Health Perspectives
Background: A structurally diverse group of chemicals, including dioxins [e.g., 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)] and polycyclic aromatic hydrocarbons (PAHs), can xenobiotically activate the aryl hydrocarbon receptor (AHR) and contribute to
Autor:
Jane K. La Du, Robert L. Tanguay, David M. Reif, Michele Balik-Meisner, Elizabeth H. Scholl, Lisa Truong
Publikováno v:
Environmental Health Perspectives
Background: Modern societies are exposed to vast numbers of potentially hazardous chemicals. Despite demonstrated linkages between chemical exposure and severe health effects, there are limited, often conflicting, data on how adverse health effects o
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 4, Iss, Pp 202-210 (2017)
Toxicology Reports, Vol 4, Iss, Pp 202-210 (2017)
Highlights • Nitroreductase-mediated tissue ablation is a useful technique in zebrafish. • Hepatic ablation can occur during early or late liver development. • Nitroreductase activity can be used for cell ablation or toxicity testing. • Chemi
Autor:
Gloria R, Garcia, Britton C, Goodale, Michelle W, Wiley, Jane K, La Du, David A, Hendrix, Robert L, Tanguay
Publikováno v:
Molecular Pharmacology
Xenobiotic activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) prevents the proper formation of craniofacial cartilage and the heart in developing zebrafish. Downstream molecular targets responsible for AHR
Autor:
Robert L. Tanguay, Susan C. Tilton, Sean M. Bugel, Katrina M. Waters, Jane K. La Du, Jill A. Franzosa, Tamara Tal
Publikováno v:
The FASEB Journal. 27:4866-4876
Retinoic acid (RA) is involved in multifarious and complex functions necessary for vertebrate development. RA signaling is reliant on strict enzymatic regulation of RA synthesis and metabolism. Improper spatiotemporal expression of RA during developm