Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Jane Harrelson"'
Autor:
Helengrace Schuck, Sheila Breidinger, Kenneth Willson, Yang Xu, Eric Woolf, Tonya Jackson, Dina Goykhman, Jane Harrelson, Ming Wang, Iris Xie
Publikováno v:
Bioanalysis. 10:1207-1220
Aim: Advances in technology have led to a shift for peptide quantification from traditional ligand-binding assays to LC–MS/MS-based analysis, which presents challenges, in other assay sensitivity, specificity and ruggedness, in addition to lacking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bedde7889ad035447394078cd1a005
https://doi.org/10.4155/bio-2018-0089
https://doi.org/10.4155/bio-2018-0089
Autor:
Marissa F. Dockendorf, Kevin P. Bateman, Iris Xie, Matthew Moyer, Jane Harrelson, Gowri Murthy, Andra Goldman, Jyoti Shah, Melanie Anderson, Rachel Ruba, Rubi Burlage, Jeffrey R. Sachs, Lisa A. Shipley, Prajakti A. Kothare
Publikováno v:
Clinical Pharmacology and Therapeutics
Merck & Co, Inc (Kenilworth, NJ) is investing in approaches to enrich clinical trial data and augment decision making through use of digital health technologies, outpatient sampling, and real‐time data access. As part of this strategy, a phase I st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84476c8e6d1a48775d9f20b18d06eaed
https://doi.org/10.1002/cpt.1142
https://doi.org/10.1002/cpt.1142
Publikováno v:
Clinical pharmacology and therapeutics. 104(6)
Advances in emerging innovative technologies have led to optimistic outlooks on their transformative potential for healthcare and clinical trials.1 Given the increased attention, this white paper by the International Consortium for Innovation and Qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9012248d3acf3765a40a6bac86e4ec36
https://pubmed.ncbi.nlm.nih.gov/29696625
https://pubmed.ncbi.nlm.nih.gov/29696625
Autor:
Maribel Beaumont, Kerry L. Fillgrove, Kevin P. Bateman, Scott Fauty, Qian Zhang, Daniela M. Tomazela, Jane Harrelson, Jacqueline Kenny, Lisa A Vasicek, BaoJen Shyong, Daniel S. Spellman
Publikováno v:
Bioanalysis. 8(7)
Aim: Reduce animal usage for discovery-stage PK studies for biologics programs using microsampling-based approaches and microscale LC–MS. Methods & results: We report the development of an automated DBS-based serial microsampling approach for study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a276702070a0b7c2aff9149a6be2fb
https://pubmed.ncbi.nlm.nih.gov/26977979
https://pubmed.ncbi.nlm.nih.gov/26977979
Autor:
Thompson Cd, Maciolek C, Declercq R, Christopher R. Gibson, Tsou Ja, Roger Smith, Wang Yh, Michele Trucksis, Joel A. Klappenbach, Joshua McElwee, Panorchan P, T Laethem, Peggy H. Wong, Jane Harrelson, Vets E, Marian Iwamoto, Peter M. Shaw, John A. Wagner, Gregory J. Opiteck, Garrett Gc, Willson Kj, Prueksaritanont T
Publikováno v:
Clinical Pharmacology and Therapeutics
MK-7246, an antagonist of the chemoattractant receptor on T helper type 2 (Th2) cells, is being developed for the treatment of respiratory diseases. In a first-in-human study, we investigated whether genetic polymorphisms contributed to the marked in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3aa0f985ec18db4c129dcc3f55270e4
https://doi.org/10.1038/clpt.2012.20
https://doi.org/10.1038/clpt.2012.20
Autor:
Bernard K. Choi, Daniela M. Tomazela, Wolfgang Seghezzi, Yaoli Song, Maribel Beaumont, Mohammad Tabrizifard, Nathan G. Hatcher, Kevin P. Bateman, Jane Harrelson, Deepa Prabhavalkar, Qian Zhang, Daniel S. Spellman
Publikováno v:
Analytical chemistry. 86(17)
Quantitation of therapeutic monoclonal antibodies (mAb) using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for pharmacokinetic (PK) studies is becoming an essential complement to traditional antibody-based ligand binding assays (LBA). He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a651e6bdaa53ba1d0ed73673757636
https://pubmed.ncbi.nlm.nih.gov/25010922
https://pubmed.ncbi.nlm.nih.gov/25010922
Autor:
Thomayant Prueksaritanont, Jane Harrelson, Mark E. Fraley, Chunze Li, George D. Hartman, Bing Lu, Robert M. Garbaccio, Edward S. Tasber, Jingjing Ye
Publikováno v:
Biochemical pharmacology. 79(10)
Compound A, 1-{(3R,3aR)-3-[3-(4-acetylpiperazin-1-yl)propyl]-7-fluoro-3-phenyl-3a,4-dihydro-3H-pyrazolo[5,1-c][1,4]benzoxazin-2-yl}ethanone, is a novel and potent inhibitor of the mitotic kinesin spindle protein. Metabolism studies with human hepatoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018661a56e9cf152cc4c566e37c47955
https://pubmed.ncbi.nlm.nih.gov/20109439
https://pubmed.ncbi.nlm.nih.gov/20109439