Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Jane H. C. Lin"'
Autor:
Nancy Ann Oberheim, Takahiro Takano, Xiaoning Han, Wei He, Jane H. C. Lin, Fushun Wang, Qiwu Xu, Jeffrey D. Wyatt, Webster Pilcher, Jeffrey G. Ojemann, Bruce R. Ransom, Steven A. Goldman, Maiken Nedergaard
Publikováno v:
The Journal of Neuroscience. 29:3276-3287
Defining the microanatomic differences between the human brain and that of other mammals is key to understanding its unique computational power. Although much effort has been devoted to comparative studies of neurons, astrocytes have received far les
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8bbb4fa650d763ccfbd912a3be0b6d3
https://doi.org/10.1523/jneurosci.4707-08.2009
https://doi.org/10.1523/jneurosci.4707-08.2009
Publikováno v:
Glia. 56:1791-1798
Gap junctions are intercellular channels formed by hemichannels (or connexons) from two neighboring cells. Hemichannels, which are composed of proteins called connexins, can function as conduits of ATP and glutamate, and interact with adhesion molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e49c1f15e533197d2f8542a575c68e8
https://doi.org/10.1002/glia.20728
https://doi.org/10.1002/glia.20728
Autor:
Jane H.-C. Lin, Nanhong Lou, Ning Kang, Takahiro Takano, Furong Hu, Xiaoning Han, Qiwu Xu, Ditte Lovatt, Arnulfo Torres, Klaus Willecke, Jay Yang, Jian Kang, Maiken Nedergaard
Publikováno v:
The Journal of Neuroscience. 28:681-695
Preconditioning is an endogenous mechanism in which a nonlethal exposure increases cellular resistance to subsequent additional severe injury. Here we show that connexin 43 (Cx43) plays a key role in protection afforded by preconditioning. Cx43 null
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5df650915847861207ccddd3465ee6
https://doi.org/10.1523/jneurosci.3827-07.2008
https://doi.org/10.1523/jneurosci.3827-07.2008
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Autor:
Ditte Lovatt, Ursula Sonnewald, Helle S. Waagepetersen, Arne Schousboe, Wei He, Jane H.-C. Lin, Xiaoning Han, Takahiro Takano, Su Wang, Fraser J. Sim, Steven A. Goldman, Maiken Nedergaard
Publikováno v:
The Journal of Neuroscience. 27:12255-12266
Protoplasmic astrocytes are critically important to energy metabolism in the CNS. Our current understanding of the metabolic interactions between neurons and glia is based on studies using cultured cells, from which mainly inferential conclusions hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9415ac280a6c198654aaba5e6931d75a
https://doi.org/10.1523/jneurosci.3404-07.2007
https://doi.org/10.1523/jneurosci.3404-07.2007
Publikováno v:
Journal of Biological Chemistry. 282:24185-24197
Recent studies indicate that astrocytes can play a much more active role in neuronal circuits than previously believed, by releasing neurotransmitters such as glutamate and ATP. Here we report that local application of glutamate or glutamine syntheta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd2aa79bb6bd370dc9136c20e51b9c9
https://doi.org/10.1074/jbc.m700452200
https://doi.org/10.1074/jbc.m700452200
Autor:
Jane H.-C. Lin, Takahiro Takano, Gregory Arcuino, Xiaohai Wang, Furong Hu, Zbigniew Darzynkiewicz, Marta Nunes, Steven A. Goldman, Maiken Nedergaard
Publikováno v:
Developmental Biology. 302(1):356-366
Neural stem and progenitor cells typically exhibit a density-dependent survival and expansion, such that critical densities are required below which clonogenic progenitors are lost. This suggests that short-range autocrine factors may be critical for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::713b5ab367db5b0567415cc5cc538d6d
Autor:
Takahiro Takano, Jian Kang, Jyoti K. Jaiswal, Sanford M. Simon, Jane H.-C. Lin, Yufei Yu, Yuxing Li, Jay Yang, Gerald Dienel, H. Ronald Zielke, Maiken Nedergaard
Publikováno v:
Proceedings of the National Academy of Sciences. 102:16466-16471
Several lines of work have shown that astrocytes release glutamate in response to receptor activation, which results in a modulation of local synaptic activity. Astrocytic glutamate release is Ca 2+ -dependent and occurs in conjunction with exocytosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b322db7b8915b412f0773ec347a2489
https://doi.org/10.1073/pnas.0506382102
https://doi.org/10.1073/pnas.0506382102
Publikováno v:
Brain Research. 901:55-61
Astrocytic gap junctions have been implicated in a variety of signaling pathways essential to normal brain function. However, no information exists on the prevalence of gap junction channels and their function in the aging brain. Here we have compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d97aa6674e398fbd932e4aac7d5626
https://doi.org/10.1016/s0006-8993(01)02258-2
https://doi.org/10.1016/s0006-8993(01)02258-2
Publikováno v:
Atherosclerosis. 144:357-365
In this study, the effect of low density lipoproteins (LDL) on the ability of the vascular endothelium to respond to vascular cell adhesion molecule 1 (VCAM-1) activation by a cytokine was investigated. After a 4-day pre-exposure to 240 mg/dl of LDL,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d1f32f5026c1037caf5609def6b63d
https://doi.org/10.1016/s0021-9150(99)00005-2
https://doi.org/10.1016/s0021-9150(99)00005-2
Autor:
M. Nedergaard, Maria Luisa Cotrina, Christian C. Naus, H. Azmi-Ghadimi, Jian Kang, Jiang Li, A. Alves-Rodrigues, Jane H.-C. Lin, Shujun Liu
Publikováno v:
Proceedings of the National Academy of Sciences. 95:15735-15740
Forced expression of gap junction proteins, connexins, enables gap junction-deficient cell lines to propagate intercellular calcium waves. Here, we show that ATP secretion from the poorly coupled cell lines, C6 glioma, HeLa, and U373 glioblastoma, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94dda23f069e9b1463eef71f34d3e606
https://doi.org/10.1073/pnas.95.26.15735
https://doi.org/10.1073/pnas.95.26.15735