Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jane Gong"'
Autor:
Douglas W. Morgan, H. Robin Heyman, Michael R. Michaelides, Jamie R. Stacey, Patrick A. Marcotte, Yan Guo, Steven K. Davidsen, Michael L. Curtin, Carole L. Goodfellow, Joseph F. Dellaria, Daniel H. Albert, Jane Gong, James H. Holms, Terrance J. Magoc, Jennifer J. Bouska, Ildiko B. Elmore, Carol K. Wada
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:1553-1556
A novel series of biaryl ether reverse hydroxamate MMP inhibitors has been developed. These compounds are potent MMP-2 inhibitors with limited activity against MMP-1. Select members of this series exhibit excellent pharmacokinetic properties with lon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::788fb32bf8edf4d1c3ceda6d5a875b22
https://doi.org/10.1016/s0960-894x(01)00031-2
https://doi.org/10.1016/s0960-894x(01)00031-2
Autor:
Xumiao Zhao, Kent D. Stewart, Dalton Christopher R, Daryl R. Sauer, Vicki L. Nienaber, Jennifer J. Bouska, Milan Bruncko, Moshe Weitzberg, Vincent L. Giranda, Todd W. Rockway, Robert A. Mantei, Jane Gong, Vered Klinghofer, Mcclellan William J, Joseph F. Dellaria, Kaminski Michele A, Geyer Andrew George, Wendt Michael D
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(1)
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0e0b72f35445b990556268ebcb9108
https://pubmed.ncbi.nlm.nih.gov/15582418
https://pubmed.ncbi.nlm.nih.gov/15582418
Autor:
Terrance J. Magoc, Douglas W. Morgan, Robert B. Garland, Michael L. Curtin, Douglas H. Steinman, Yan Guo, Paul Tapang, H. Robin Heyman, Carol K. Wada, James H. Holms, Ildiko B. Elmore, Steven K. Davidsen, Joy Bauch, Alan S. Florjancic, Patrick A. Marcotte, Daniel H. Albert, Joseph F. Dellaria, Carole L. Goodfellow, Jane Gong, Jennifer J. Bouska, Michael R. Michaelides, Kennan C. Marsh
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(12)
Modification of the biphenyl portion of MMP inhibitor 2a gave analogue 2i which is greater than 1000-fold selective against MMP-2 versus MMP-1. The stereospecific synthesis of both enantiomers of 2i was achieved beginning with (S)- or (R)-benzyl glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae58d179b83e3cac44f28dc88e780f48
https://pubmed.ncbi.nlm.nih.gov/11412980
https://pubmed.ncbi.nlm.nih.gov/11412980