Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jane E. Hartung"'
Autor:
Emanuel Loeza-Alcocer, Wolfgang Schroeder, Jane E. Hartung, Thomas Christoph, Michael S. Gold, Jamie K. Moy, Ruth Jostock, Vidhya Nagarajan
Publikováno v:
Pain
Voltage gated calcium currents (VGCCs) in sensory neurons underlie processes ranging from neurotransmitter release to gene expression and remain a therapeutic target for the treatment of pain. Yet virtually all we know about VGCCs has been obtained t
Autor:
Dipna A Patel, Jane E. Hartung, Tzahi Cohen-Karni, Yingqiao Wang, Adam Goad, Yury Gogotsi, Michael S. Gold, Raghav Garg, Flavia Vitale
Publikováno v:
ACS Nano. 15:14662-14671
Understanding cellular electrical communications in both health and disease necessitates precise subcellular electrophysiological modulation. Nanomaterial-assisted photothermal stimulation was demonstrated to modulate cellular activity with high spat
Autor:
Maysam Chamanzar, Seokhyoung Kim, Tzahi Cohen-Karni, Sahil K. Rastogi, James F. Cahoon, Corban G.E. Murphey, Matteo Giuseppe Scopelliti, Nicholas Johnson, Bernardo I. Pinto, Raghav Garg, Francisco Bezanilla, Jane E. Hartung, Michael S. Gold, Daniel San Roman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Modulation of cellular electrophysiology helps develop an understanding of cellular development and function in healthy and diseased states. We modulate the electrophysiology of neuronal cells in two-dimensional (2D) and 3D assemblies wi
Autor:
Yingqiao, Wang, Raghav, Garg, Jane E, Hartung, Adam, Goad, Dipna A, Patel, Flavia, Vitale, Michael S, Gold, Yury, Gogotsi, Tzahi, Cohen-Karni
Publikováno v:
ACS nano. 15(9)
Understanding cellular electrical communications in both health and disease necessitates precise subcellular electrophysiological modulation. Nanomaterial-assisted photothermal stimulation was demonstrated to modulate cellular activity with high spat
Autor:
Michael S. Gold, Xiulin Zhang, Robert L. Friedman, Jane E. Hartung, H. Richard Koerber, Inna Belfer
Publikováno v:
J Pain
Sensory neuron nicotinic acetylcholine receptors (nAChRs) contribute to pain associated with tissue injury. However, there are marked differences between rats and mice with respect to both the properties and distribution of nAChR currents in sensory
Autor:
Emanuel Loeza-Alcocer, H. Richard Koerber, Michael S. Gold, Melissa Giraldo Duque, Vidhya Nagarajan, Jamie K. Moy, Wolfgang P. Schröder, Thomas Christoph, Robert Friedman, Jane E. Hartung
Publikováno v:
Pain
Preclinical evidence has highlighted the importance of the μ-opioid peptide (MOP) receptor on primary afferents for both the analgesic actions of MOP receptor agonists, as well as the development of tolerance, if not opioid-induced hyperalgesia. The
Autor:
Andrey V. Bortsov, Xin Zhang, Jane E. Hartung, Seungtae Kim, Julia Kozlowski, Andrea G. Nackley, Sandra C. O’Buckley
Publikováno v:
Brain, Behavior, and Immunity. 73:520-532
Functional pain syndromes, such as fibromyalgia and temporomandibular disorder, are associated with enhanced catecholamine tone and decreased levels of catechol-O-methyltransferase (COMT; an enzyme that metabolizes catecholamines). Consistent with cl
Autor:
Raghav Garg, Tzahi Cohen-Karni, Jane E. Hartung, Kyoungin Kang, Yury Gogotsi, Adam Goad, Flavia Vitale, Yingqiao Wang, Michael S. Gold
Publikováno v:
ECS Meeting Abstracts. :507-507
The ability to probe and manipulate electrophysiology at the cellular level is crucial for understanding cellular communications and enabling new therapeutics for neurological and psychiatric disorders. Nanomaterial-facilitated photothermal stimulati
Publikováno v:
The Journal of Pain. 22:589
Lipid nanoparticles (LNPs) are a clinically approved platform to deliver siRNA to the liver. We are optimizing this platform to deliver siRNA for the treatment of pain. siRNA against TRPV1 (siTRPV1) was chosen as a proof of concept. siTRPV1-LNPs were
Autor:
Michael S. Gold, Wolfgang Schroeder, Emanuel Loeza-Alcocer, Ruth Jostock, Vidhya Nagarajan, Jane E. Hartung, Jamie K. Moy, Thomas Christoph
Publikováno v:
The Journal of Pain. 22:582
Voltage gated calcium channels (VGCCs) in sensory neurons, as with almost all excitable cells, are responsible for initiating a variety of cellular processes ranging from transmitter release to changes in gene expression. VGCCs are also a primary tar