Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jane E. Dixon"'
Autor:
Hong-Sheng Wang, Ira S. Cohen, David McKinnon, Jane E. Dixon, Steven Lypen, Zongming Pan, Barbara Rosati
Publikováno v:
The Journal of Physiology. 533:119-125
Expression of four members of the KChIP family of potassium channel β subunits was examined in canine heart. Only one member of the gene family, KChIP2, was expressed in heart. There was a steep gradient of KChIP2 mRNA expression across the canine v
Autor:
Randy S. Wymore, Wenmei Shi, David McKinnon, Barry S. Brown, Hong-Sheng Wang, Zongming Pan, Jane E. Dixon, Ira S. Cohen
Publikováno v:
Science. 282:1890-1893
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been ident
Publikováno v:
Circulation Research. 80:261-268
The human K + channel gene, HERG, has been linked to the type 2 form of the autosomal dominant long-QT syndrome and has been suggested to encode the fast component of the delayed rectifier K + current (I Kr ) found in heart. To date, the published el
Autor:
Jeanne M. Nerbonne, Dianne M. Barry, Jane E. Dixon, Haodong Xu, David McKinnon, John P. Merlie, James S. Trimmer
Publikováno v:
The Journal of General Physiology
In the experiments here, the developmental expression of the functional Ca(2+)-independent, depolarization-activated K+ channel currents, Ito and IK, and of the voltage-gated K+ channel (Kv) alpha subunits, Kv1.2, Kv1.4, Kv1.5, Kv2.1, and Kv4.2 in ra
Autor:
B. Holmes, Hong-Zhan Wang, David McKinnon, Jane E. Dixon, Joan Zuckerman, William B. Benjamin, Hangang Yu, Rigel T. Wymore, Randy S. Wymore, Ira S. Cohen, M. R. El-Maghrabi, Richard B. Robinson, Wenmei Shi, Irina A. Potapova, Zongming Pan, Jiying Wu
Publikováno v:
Circulation research. 88(12)
Abstract —The HCN family of ion channel subunits underlies the currents I f in heart and I h and I q in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a β subunit for the HCN family. As such, it enh
Publikováno v:
The Journal of physiology. 531(Pt 2)
The region of alternative splicing in the KCNQ2 potassium channel gene was determined by RNase protection analysis of KCNQ2 mRNA transcripts. Systematic analysis of KCNQ2 alternative splice variant expression in rat superior cervical ganglia revealed
Autor:
David McKinnon, Richard B. Robinson, Ira S. Cohen, Wenmei Shi, Jiying Wu, Hangang Yu, Randy S. Wymore, Jane E. Dixon, Rigel T. Wymore, Zongming Pan
Publikováno v:
Circulation research. 85(1)
Abstract —HCN cation channel mRNA expression was determined in the rabbit heart and neonatal and adult rat ventricle using RNase protection assays. In the rabbit SA node, the dominant HCN transcript is HCN4, representing >81% of the total HCN messa
Autor:
Evgeny P. Anyukhovsky, Randy S. Wymore, Hangang Yu, Alexei Shvilkin, Michael R. Rosen, Jane E. Dixon, Ira S. Cohen, Junyuan Gao, Peter Danilo, David McKinnon, Eugene A. Sosunov, Motoki Hara
Publikováno v:
Circulation. 99(14)
Background —Cardiac memory refers to an altered T-wave morphology induced by ventricular pacing or arrhythmias that persist for variable intervals after resumption of sinus rhythm. Methods and Results —We induced long-term cardiac memory (LTM) in
Autor:
Ira S. Cohen, Y. Wang, Richard T. Mathias, Junyuan Gao, R. T. Wymore, David McKinnon, G. J. Baldo, Randy S. Wymore, Jane E. Dixon
Publikováno v:
The Journal of physiology. 516
1. Guinea-pig ventricle was used in the RNase protection assays to determine which alpha-isoforms of the Na+-K+ pumps are present, and ventricular myocytes were used in whole cell patch clamp studies to investigate the actions of alpha- and beta-adre
Autor:
Stefan Kääb, D. Ashen, Gordon F. Tomaselli, J. Duc, Michael Nabauer, Dirk J. Beuckelmann, David McKinnon, Jane E. Dixon, Gerhard Steinbeck
Publikováno v:
Circulation. 98(14)
Background —Despite advances in medical therapy, congestive heart failure remains a major cause of death in the developed world. A disproportionate number of the deaths of patients with heart failure are sudden and presumed to be arrhythmic. Heart